Clemson vs South Carolina Prediction 11/29/2025 Today’s College Football Picks

The Clemson Tigers and South Carolina Gamecocks meet Saturday in college football action at Peden Stadium. Here’s a Clemson vs South Carolina Prediction. This article will include a Clemson vs South Carolina Pick.

Clemson Tigers Betting Preview

The Clemson Tigers beat Louisville and Furman. Clemson has won 3 straight games. Cade Klubnik is completing 67.2 percent of his passes for 2,482 yards, 16 touchdowns, and 5 interceptions. Antonio Williams and T.J. Moore have combined for 1,191 receiving yards and 8 touchdowns, while Bryant Wesco Jr. has 31 receptions.

The Clemson Tigers ground game is averaging 142.8 yards per contest, and Adam Randall leads the way with 677 yards and 8 touchdowns. Defensively, Clemson is allowing 23.1 points and 382.3 yards per game. Sammy Brown leads the Clemson Tigers with 82 tackles, Will Heldt has 6 sacks and Ricardo Jones has 4 interceptions.

South Carolina Gamecocks Betting Preview

The South Carolina Gamecocks lost to Texas A&M and beat Coastal Carolina. The South Carolina Gamecocks have lost 5 of their last 6 games. LaNorris Sellers is completing 61.8 percent of his passes for 2,056 yards, 11 touchdowns, and 6 interceptions. Vandrevius Jacobs and Nyck Harbor have combined for 910 receiving yards and 8 touchdowns, while Jayden Sellers has 17 receptions.

The South Carolina Gamecocks ground game is averaging 130.5 yards per contest, and Rahsul Faison leads the way with 433 yards and 3 touchdowns. Defensively, South Carolina is allowing 23.7 points and 382.1 yards per game. DQ Smith leads the South Carolina Gamecocks with 60 tackles, Bryan Thomas Jr. has 7 sacks and Gerald Kilgore has 2 interceptions.

Why the South Carolina Gamecocks will win

• South Carolina has won each of its last eight games as a favorite against teams from South Carolina.
• Clemson has lost six of its last eight games against opponents from the Southeastern Conference.
• Clemson has failed to cover the spread in 10 of its last 11 games in South Carolina.
• The favorite has covered the spread in each of the last four games between Clemson and South Carolina at Williams-Brice Stadium.

Why the Clemson Tigers will win

• Clemson has won 20 of its last 22 games against teams from South Carolina.
• The road team has covered the spread in seven of Clemson’s last eight games.

Total Points Facts

• Each of South Carolina’s last four home games against Clemson have gone UNDER the total points line.
• Each of Clemson’s last four road games in November have gone UNDER the total points line.

South Carolina Gamecocks Player Prop Facts

• Heading into Week 14, Bryan Thomas Jr. ranks T21st amongst FBS players for sacks (7.0) this season.

Clemson Tigers Player Prop Facts

• Heading into Week 14, Bryant Wesco Jr. ranks T1st in the Atlantic Coast Conference for receiving touchdowns (6) this season.

Matchup/League Facts

• South Carolina ranks T128th among FBS teams for H2 points per game this season (8.0).
• South Carolina ranks T126th among FBS teams for average point differential in fourth quarters this season (-3.6).
• Clemson ranks 24th among FBS teams for rushing yards allowed per game this season (108.5).
• Clemson ranks 24th among FBS teams for passing yards per game this season (274.5).

Clemson vs South Carolina Prediction

This has been an underachieving season for Clemson, and we’ve money fading this group that’s also 4-6 ATS. However, I’m not sure what South Carolina has done to be favored. I get it’s a rivalry game and South Carolina is at home on senior night with 26 seniors, but the Gamecocks have arguably been even worse than Clemson this season. Clemson has at least won 3 straight games and has shown recent life on both sides of the ball.

Despite having a star capable quarterback, South Carolina is nonexistent offensively most weeks and has scored 14 or fewer points in 4 of its last 9 games. Clemson has won 8 of the last 10 games against South Carolina. Given the current form, I kind of expect Clemson to win this game outright. I’ll gladly take the points while snagging the ML as well.

Randy Chambers's Pick: Clemson +2.5