California vs Louisville Prediction 11/8/2025 Today’s College Football Picks

In this article we will formulate a California vs Louisville prediction for this College Football game on Saturday, November 8th at L&N Federal Credit Union Stadium in Louisville, Kentucky. Let’s take a look at the prediction for this week 11 matchup. 

California Golden Bears Betting Preview

The California Golden Bears are 5-4 (2-3) this season after they lost to Virginia by a score of 31-21 in their last game. California trailed 17-7 at halftime, but cut the deficit to 24-21 in the fourth, before throwing a pick six late in the loss. The Golden Bears were out gained by a total of 456-263, went 3-12 on third downs, and lost the turnover battle by a total of 2-0 in the game. Jaron-Keawe Sagapolutele went 19-30 for 213 yards and two interceptions, while Kendrick Raphael rushed 13 times for 46 yards and two scores. Trond Grizzell led the receivers with eight catches for 80 yards in the loss. The Cal defense recorded two sacks and six tackles for loss in the game. 

Prior to that game, California lost to Virginia Tech by a score of 42-34 in overtime, but did beat North Carolina by a score of 21-18 before that. The Golden Bears have lost three of their last four games and they are currently tied for eighth in the ACC standings. California has scored 24.6 points per game with 253.9 passing yards and 78.6 rushing yards per game, while they have allowed 25.1 points against per game this season. Jaron-Keawe Sagapolutele has thrown for 2,195 yards, 11 touchdowns, and nine interceptions, while Kendrick Raphael has rushed for 612 yards and 10 scores on 148 carries this season. 

Louisville Cardinals Betting Preview

The Louisville Cardinals are 7-1 (4-1) this year after they defeated Virginia Tech by a score of 28-16 last week. Louisville trailed 16-7 at halftime, but out scored Virginia Tech 21-0 in the second half for the comeback win. The Cardinals out gained VT by a total of 371-240, went 4-11 on third downs, and lost the turnover battle by a total of 1-0 in the game. Miller Moss went 19-28 for 136 yards, one touchdown, and one interception, while Isaac Brown rushed 16 times for 130 yards and one score. Chris Bell led the receivers with eight receptions for 56 yards in the game. The Louisville defense recorded zero sacks and five tackles for loss in the win. 

Prior to that game, Louisville defeated Boston College by a score of 38-24 and Miami by a score of 24-21. The Cardinals have won three games in a row and they are currently tied for fourth in the ACC standings. Louisville has scored 33.8 points per game with 252.0 passing yards and 155.8 rushing yards per game, while they have allowed 20.8 points against per game this season. Miller Moss has thrown for 1,929 yards, 11 touchdowns, and six interceptions, while Isaac Brown has rushed 91 times for 782 yards and five scores this year. 

Why the Louisville Cardinals will win

• California has lost each of its last 11 games against top-15 AP-ranked teams.
• Louisville has won each of its last eight games as a favorite against non-AP-ranked teams.
• California has failed to cover the spread in each of its last four games.
• Louisville has covered the spread in each of its last three games in November.

Total Points Facts

• Nine of California’s last 12 road games against top-15 AP-ranked teams have gone UNDER the total points line.
• Three of Louisville’s last four games have gone UNDER the total points line.

Matchup/League Facts

• Louisville ranks 9th among FBS teams for 1st downs against this season (122).
• Louisville ranks T9th among FBS teams for 4th down conversion percentage against this season (33.3).
• California ranks 108th among FBS teams for yards per game this season (332.4).
• California ranks 98th among FBS teams for Q3 points per game this season (4.7).

California vs Louisville Prediction 

Louisville was able to survive a bad first half against Virginia Tech last week, as they remain in the ACC race. The Cardinals have scored 27+ points in four of their last five games and will face a Cal defense that has allowed 31+ in three of their last four. The Golden Bears have lost three of their last four games and while their offense has been decent, I can’t trust their defense at all. Take Louisville to win easily here.

David Racey is 104-85 (55%) in College Football this season and is one of the top College Football Handicappers on the site. Click here for his premium plays for the week!

David Racey's Pick: Louisville -20.5