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BYU vs Colorado Prediction 9/27/2025 Today’s College Football Picks
Pick details
BYU (3-0) vs Colorado (2-2)
September 27, 2025 at 10:15 PM EDT
The Line: Betting Odds: Colorado +6.5 — Over/Under: +47.5
The BYU Cougars and Colorado Buffaloes meet Saturday in college football action at Folsom Field. Here’s a BYU vs Colorado Prediction. This article will include a BYU vs Colorado Pick.
The BYU Cougars beat Stanford and East Carolina, and they play West Virginia next. BYU has won 5 straight games. Bear Bachmeier is completing 66.7 percent of his passes for 518 yards, 4 touchdowns, and 0 interceptions. Chase Roberts and Carsen Ryan have combined for 331 receiving yards and 3 touchdowns, while Parker Kingston has 9 receptions.
The BYU Cougars ground game is averaging 265.7 yards per contest, and LJ Martin leads the way with 342 yards and 1 touchdown. Defensively, BYU is allowing 5.3 points and 205.3 yards per game. Logan Lutui leads the BYU Cougars with 15 tackles, Jack Kelly has 3 sacks and Evan Johnson has 2 interceptions.
The Colorado Buffaloes lost to Houston, beat Wyoming, and they play TCU next. Colorado has won 10 of its last 15 games. Kaidon Salter is completing 66.7 percent of his passes for 565 yards, 4 touchdowns, and 0 interceptions. Sincere Brown and Omarion Miller have combined for 384 receiving yards and 3 touchdowns, while Joseph Williams has 9 receptions.
The Colorado Buffaloes ground game is averaging 141.3 yards per contest, and Kaidon Salter leads the way with 153 yards and 3 touchdowns. Defensively, Colorado is allowing 22.5 points and 409.3 yards per game. Tawfiq Byard leads the Colorado Buffaloes with 27 tackles, Arden Walker has 1.5 sacks and RJ Johnson has 1 interception.
BYU hasn’t had the toughest schedule up to this point, but it’s proven to e one of the more balanced teams in the country. BYU is top-20 in scoring offense and second in both total defense and scoring defense. Meanwhile, Colorado still has questions at quarterback and struggles to finish drives, while the defense can’t stop the run and is 112th in total defense. BYU crushed Colorado back in December by 22 points, and you can argue the Buffaloes were far more talented than they are this season. The crowd will be out and Colorado has moments where it can hang around, but BYU is too consistent on both sides of the ball. I’ll lay the points.
BYU Cougars Betting Preview
The BYU Cougars beat Stanford and East Carolina, and they play West Virginia next. BYU has won 5 straight games. Bear Bachmeier is completing 66.7 percent of his passes for 518 yards, 4 touchdowns, and 0 interceptions. Chase Roberts and Carsen Ryan have combined for 331 receiving yards and 3 touchdowns, while Parker Kingston has 9 receptions.
The BYU Cougars ground game is averaging 265.7 yards per contest, and LJ Martin leads the way with 342 yards and 1 touchdown. Defensively, BYU is allowing 5.3 points and 205.3 yards per game. Logan Lutui leads the BYU Cougars with 15 tackles, Jack Kelly has 3 sacks and Evan Johnson has 2 interceptions.
Colorado Buffaloes Betting Preview
The Colorado Buffaloes lost to Houston, beat Wyoming, and they play TCU next. Colorado has won 10 of its last 15 games. Kaidon Salter is completing 66.7 percent of his passes for 565 yards, 4 touchdowns, and 0 interceptions. Sincere Brown and Omarion Miller have combined for 384 receiving yards and 3 touchdowns, while Joseph Williams has 9 receptions.
The Colorado Buffaloes ground game is averaging 141.3 yards per contest, and Kaidon Salter leads the way with 153 yards and 3 touchdowns. Defensively, Colorado is allowing 22.5 points and 409.3 yards per game. Tawfiq Byard leads the Colorado Buffaloes with 27 tackles, Arden Walker has 1.5 sacks and RJ Johnson has 1 interception.
BYU Cougars @ Colorado Buffaloes Betting Trends: Week 5
Why the Colorado Buffaloes will win
- Colorado has won five of its last six games in September.
- Colorado has covered the spread in eight of its last nine games against conference opponents at Folsom Field.
Why the BYU Cougars will win
- BYU has won each of its last 13 September games as a favorite against non-AP-ranked teams.
- Colorado has lost each of its last seven games against AP-ranked teams.
- BYU has covered the spread in each of its last six September games against non-AP-ranked teams.
- Colorado has failed to cover the spread in three of its last four games against conference opponents.
Total Points Facts
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- Four of Colorado’s last five games in September have gone OVER the total points line.
- Seven of BYU’s last nine games against conference opponents have gone OVER the total points line.
Colorado Buffaloes Player Prop Facts
- Heading into Week 5, Kaidon Salter leads Colorado for touchdowns (3) this season.
BYU Cougars Player Prop Facts
- Heading into Week 5, LJ Martin is one of only seven players in the FBS to record 100+ rushing yards in three or more consecutive games this season.
Matchup/League Facts
- Colorado ranks T23rd among FBS teams for 4th down conversion percentage this season (75.0).
- Colorado ranks T113th among FBS teams for average point differential in third quarters this season (-2.5).
- BYU ranks 1st among FBS teams for average point differential in second quarters this season (+17.7).
- BYU ranks T2nd among FBS teams for H1 opponent points per game this season (1.0).
BYU vs Colorado Prediction
BYU hasn’t had the toughest schedule up to this point, but it’s proven to e one of the more balanced teams in the country. BYU is top-20 in scoring offense and second in both total defense and scoring defense. Meanwhile, Colorado still has questions at quarterback and struggles to finish drives, while the defense can’t stop the run and is 112th in total defense. BYU crushed Colorado back in December by 22 points, and you can argue the Buffaloes were far more talented than they are this season. The crowd will be out and Colorado has moments where it can hang around, but BYU is too consistent on both sides of the ball. I’ll lay the points.
