Vanderbilt vs Missouri Prediction College Football Picks 9/21/24

Pick details

Missouri (3-0) vs Vanderbilt (2-1)

September 21, 2024 at 04:15 PM EDT

The Line: Betting Odds: Missouri -20.5 / Vanderbilt +20.5 — Over/Under: 53.5

(Get latest betting odds)

The Vanderbilt Commodores and Missouri Tigers meet Saturday in week 4 college football action at Memorial Stadium. Here’s a Vanderbilt vs Missouri Prediction. This article will include a Vanderbilt vs Missouri Pick.

Vanderbilt Commodores Betting Preview

The Vanderbilt Commodores beat Alcorn State, lost to Georgia State, and play Alabama next. The Vanderbilt Commodores haven’t won a road game since November 2022. Diego Pavia is completing 64.5 percent of his passes for 543 yards, 4 touchdowns, and 0 interceptions. Eli Stowers and Quincy Skinner Jr. have combined for 286 receiving yards and 2 touchdowns, while Junior Sherrill has 6 receptions.

The Vanderbilt Commodores ground game is averaging 177.7 yards per contest, and Pavia leads the way with 195 yards and 2 touchdowns. Defensively, Vanderbilt is allowing 21 points and 298 yards per game. Langston Patterson leads the Vanderbilt Commodores with 18 tackles, Linus Zunk has 1.5 sacks and Glenn Seabrooks III has 1 interception.

Missouri Tigers Betting Preview

The Missouri Tigers beat Murray State, Buffalo, and Boston College, and they play Texas A&M next. The Missouri Tigers look for back-to-back 4-0 starts. Brady Cook is completing 71.1 percent of his passes for 720 yards, 2 touchdowns, and 1 interception. Theo Wease Jr. and Luther Burden III have combined for 413 receiving yards and 2 touchdowns, while Mookie Cooper has 7 receptions.

The Missouri Tigers ground game is averaging 203.3 yards per contest, and Nate Noel leads the way with 242 yards and 2 touchdowns. Defensively, Missouri is allowing 7 points and 184 yards per game. Corey Flagg Jr. leads the Missouri Tigers with 15 tackles, Khalil Jacobs has 2 sacks and Dreyden Norwood has 1 interception.

Why the Missouri Tigers will win

  • Vanderbilt has lost 25 of its last 26 games against AP-ranked teams.
  • Missouri has won each of its last eight September games at Faurot Field at Memorial Stadium.
  • Vanderbilt has failed to cover the spread in seven of its last eight September games as an underdog.
  • Missouri has covered the spread in six of its last seven games as a favorite against non-AP-ranked teams.
  • Missouri has won the first half in each of its last four home games against conference opponents.

Total Points Facts


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  • Twelve of Vanderbilt’s last 13 road games against top-15 AP-ranked teams have gone UNDER the total points line.
  • Five of Missouri’s last six games at Faurot Field at Memorial Stadium have gone UNDER the total points line.

Matchup/League Facts

  • Missouri ranks T6th among FBS teams for 1st downs against this season (30).
  • Missouri ranks 7th among FBS teams for passing yards allowed per game this season (110.3).
  • Vanderbilt ranks T16th among FBS teams for H1 opponent points per game this season (5.0).
  • Vanderbilt ranks T119th among FBS teams for H2 opponent points per game this season (16.0).

Vanderbilt vs Missouri Prediction

The Vanderbilt Commodores lost some of their love from oddsmakers and bettors because of that loss to Georgia State. A Missouri Tigers beatdown wouldn’t surprise anybody. However, as I said before the season and in my Vanderbilt – Virginia Tech write-up, the Commodores have a solid play-making quarterback who can string together drives and put up points. The rest of the team may be questionable, but Vanderbilt can score enough to cover some of these big numbers. Overall, Vanderbilt has covered 5 of its last 8 games as an underdog of 20 or more points. I’ll take a shot with the free points and Vanderbilt.

Randy Chambers's Pick: Vanderbilt +20.5

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