Mar 22, 2026; Miami Gardens, FL, USA; Stefanos Tsitsipas (GRE) hits a forehand against Arthur Fils (FRA) (not pictured) on day six of the 2026 Miami Open at Hard Rock Stadium. Mandatory Credit: Geoff Burke-Imagn Images
Geoff Burke-Imagn Images

ATP Madrid: Stefanos Tsitsipas vs Casper Ruud Prediction 4/28/2026 Today’s Tennis Picks

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Madrid Open: Stefanos Tsitsipas vs Casper Ruud

08:30 AM EDT

The Line: Betting Odds: Stefanos Tsitsipas +165 / Casper Ruud -222

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Stefanos Tsitsipas will face defending champion Casper Ruud in the round of 16 of the Madrid Open on Tuesday, April 28. Here’s our Stefanos Tsitsipas vs Casper Ruud prediction. This preview will also include a Stefanos Tsitsipas vs Casper Ruud pick.

Stefanos Tsitsipas vs Casper Ruud Preview

Stefanos Tsitsipas is coming off a straight sets win over World No. 102 Merida Aguilar to record his third victory in a row for the first time since January at the United Cup. The match took 18 games to decide. Tsitsipas produced a dominant display to wrap up a 6-4, 6-2 victory in an hour and 9 minutes.

In the victory, Tsitsipas hit 20 winners and 20 unforced errors. That included 3 aces and he did not account for a double fault. Tsitsipas landed 58% of first serves in play and won 80% of first serve points (24/30). Tsitsipas won 73% of second serve points (16/22) and saved all four break points he faced on his serve. Tsitsipas won 39% of return points in the match (19/49). Before this round, Tsitsipas had beaten Patricky Kypson in three sets and Alexander Bublik in straight sets. He improves to 3-2 on clay.

Casper Ruud entered the 2026 Madrid Open as the reigning champion. The Norwegian was in doubt to feature after pulling out from Barcelona because of injury. But so far, Ruud has not experienced any problems in reaching the second week in Madrid and keeping his title defense alive. He recorded an emphatic 6-0, 6-1 win over Jaume Munar in his opening match, clinching victory in just 66 minutes.

Ruud defeated another Spaniard in the last round. He knocked out World No. 24 Alejandro Davidovich Fokina 6-3, 6-1 in an hour and 15 minutes. In the victory, Ruud hit 15 winners and 14 unforced errors. That included 3 aces and 2 double faults. He landed 62% of first serves in play and won 71% of first serve points (20/28). Ruud won 65% of second serve points (11/17) and was broken just once in the match.

Stefanos Tsitsipas vs Casper Ruud Head-To-Head

Tsitsipas and Ruud have played five times at tour level. Ruud leads their series 3-2 and he triumphed over Tsitsipas to win his first ATP 500 title in the 2024 Barcelona Open final.

Stefanos Tsitsipas vs Casper Ruud Prediction

We could be witnessing Tsitsipas’ renaissance in Madrid. It’s still too early to make such pronouncements, but I’ve been impressed by what the Greek has served ip this week with performances full of vigour and he seems to be enjoying his tennis again. This is not just another match for Ruud. He’s facing one of the best players on this surface, taking current ranking out of the equation. If Tsitsipas brings the same intensity and energy into this match, I think he’s got a chance and I’m happy to back the Greek here.

Nur Said's Pick: Tsitsipas in three sets