San Francisco 49ers vs Los Angeles Rams Prediction 10/2/2025 Today’s NFL Picks

The San Francisco 49ers and Los Angeles Rams meet Thursday in NFL action at SoFi Stadium. Here’s a San Francisco 49ers vs Los Angeles Rams Prediction. This article will include a San Francisco 49ers vs Los Angeles Rams Pick.

San Francisco 49ers Betting Preview

The San Francisco 49ers beat the Cardinals, lost to the Jaguars, and play the Buccaneers next. The San Francisco 49ers have lost 8 their last 12 games. Brock Purdy is completing 65.8 percent of his passes for 586 yards, 4 touchdowns, and 4 interceptions. Ricky Pearsall and Christian McCaffrey have combined for 632 receiving yards and 2 touchdowns, while Jauan Jennings has 9 receptions.

The San Francisco 49ers ground game is averaging 88 yards per contest, and Christian McCaffrey leads the way with 225 yards on 69 carries. Defensively, San Francisco is allowing 18.8 points and 280.5 yards per game. Fred Warner leads the San Francisco 49ers with 38 tackles, Bryce Huff has 2 sacks and Renardo Green has 3 pass deflections.

Los Angeles Rams Betting Preview

The Los Angeles Rams beat the Colts, lost to the Eagles, and they play the Ravens next. The Rams have won 12 of their last 16 regular season games. Matthew Stafford is completing 67.6 percent of his passes for 1,114 yards, 8 touchdowns, and 2 interceptions. Puka Nacua and Davante Adams have combined for 772 receiving yards and 4 touchdowns, while Tutu Atwell has 2 receptions.

The Los Angeles Rams ground game is averaging 120.8 yards per contest, and Kyren Williams leads the way with 303 yards and 1 touchdown. Defensively, Los Angeles is allowing 20.3 points and 284.5 yards per game. Kam Curl leads the Los Angeles Rams with 35 tackles, Byron Young has 5 sacks and Cobie Durant has 1 interception.

San Francisco 49ers @ Los Angeles Rams Betting Trends: Week 5

Why the Los Angeles Rams will win

• The Rams have won each of their last nine games as moderate favorites (-3.5 to -7.0 points).
• The 49ers have lost four of their last five road games following a loss.
• The 49ers have failed to cover the spread in 13 of their last 14 games against teams that held a winning record.
• The Rams have covered the spread in seven of their last eight Thursday games played on the West Coast.
• The 49ers have lost the first quarter in three of their last four October road games against NFC opponents.
• The Rams have won the first half in five of their last six Thursday games as favorites.

Why the San Francisco 49ers will win

• The 49ers have won four of their last five games as road underdogs against the Rams.
• The Rams have lost seven of their last eight Week 5 home games against NFC opponents.
• The road team has covered the spread in each of the Rams’ last six Week 5 games.
• The Rams have failed to cover the spread in each of their last four Week 5 home games against NFC opponents.
• The Rams have lost the first quarter in four of their last five Thursday games.
• The Rams have lost the first half in four of their last five home games against NFC West opponents.

Total Points Facts

• Seven of the Rams’ last eight games played as favorites on the West Coast have gone UNDER the total points line.
• Six of the 49ers’ last seven road games against NFC West opponents have gone OVER the total points line.
• Each of the last three games between NFC West teams have gone UNDER the total points line.

Los Angeles Rams Player Prop Facts

• Kyren Williams has scored the first touchdown in four of his last five regular season home appearances.
• Kyren Williams has scored at least one touchdown in each of his last eight regular season home appearances against NFC opponents.
• Matthew Stafford has recorded 279+ passing yards in four of his last five appearances following a home win.
• Kyren Williams has recorded 72+ rushing yards in seven of his last eight regular season home appearances against NFC opponents.
• Puka Nacua has recorded 98+ rushing and receiving yards in each of his last eight appearances at SoFi Stadium.
• Puka Nacua has recorded 98+ receiving yards in each of his last eight appearances at SoFi Stadium.
• Matthew Stafford has recorded 24+ completions in each of his last five Thursday home appearances.
• Heading into Week 5, Byron Young ranks T1st in the NFL in sacks (5.0) this season.

San Francisco 49ers Player Prop Facts

• Brian Robinson has scored at least one touchdown in nine of his last 10 regular season appearances with his team as a road underdog.
• Mac Jones has recorded 220+ passing yards in seven of his last eight appearances.
• Brian Robinson has recorded 31+ rushing yards in each of his last 12 regular season appearances with his team as a road underdog.
• Brian Robinson has recorded 35+ rushing and receiving yards in each of his last 19 regular season appearances with his team as an underdog.
• Kendrick Bourne has recorded 34+ receiving yards in nine of his last 10 appearances against NFC West opponents.
• Brock Purdy has recorded 22+ completions in five of his last six road appearances against NFC opponents.
• Heading into Week 5, Christian McCaffrey is one of only two players averaging over 20.0 rushing yards and 60.0 receiving yards per game this season.

Matchup/League Facts

• Rams – two different players have recorded 100+ receiving yards in a game this season – equal-most in the NFL, heading into Week 5.
• Heading into Week 5, the Rams have recorded more total yards than their opponents in four games this season – equal-most in the league.
• Heading into Week 5, the 49ers rank T1st in the NFL in average points against in first quarters this season (0.0).
• 49ers – only team with 2+ players to record 300+ receiving yards this season (Christian McCaffrey, Ricky Pearsall), heading into Week 5.

San Francisco 49ers vs Los Angeles Rams Prediction

The Rams are off to a fine start, coming off a nice win over a surprise Colts team, and Stafford is cooking with explosive receivers around him. The 49ers are banged up, and a short week probably doesn’t help. However, even with injuries, the 49ers are still a top-10 defense and are second in passing offense. It’s just a matter of finishing these drives with points. The Rams and 49ers know each other well, and it’s led to the underdog covering 8 of the last 10 meetings. In fact, the underdog has outright won 6 of those 8 covers. While I like what the Rams are doing and am a huge fan of Sean McVay, it feels like oddsmakers and bettors are writing off the 49ers too quickly, and I’m just not there yet. Give me the points on Thursday night.