San Francisco 49ers vs Green Bay Packers Prediction NFL Picks 11/24/24

Pick details

Green Bay Packers (7-3) vs San Francisco 49ers (5-5)

November 24, 2024 at 04:25 PM EST

The Line: Betting Odds: Green Bay Packers -2.5 / San Francisco 49ers +2.5 — Over/Under: 45.5

(Get latest betting odds)

The San Francisco 49ers and the Green Bay Packers meet in week 12 NFL action from Lambeau Field on Sunday afternoon. We will look at this from a betting perspective and determine the best bets for this game. Here’s a San Francisco 49ers vs. Green Bay Packers prediction.

San Francisco 49ers Recap

The San Francisco 49ers will be hoping to rebound after ending up on the wrong side of a 20-17 loss at the hands of the Seattle Seahawks to fall to 5-5 on the year. After this game, the 49ers will head out to Buffalo for a matchup with the Bills.

49ers Looking To Get Back On Track

Brock Purdy has thrown for 2,613 yards, 13 touchdowns, and 8 interceptions on 66% passing while Jordan Mason’s rushed for 703 yards and 3 touchdowns on the year. George Kittle has a team-high 43 receptions for 560 yards and 7 touchdowns while Deebo Samuel has 490 receiving yards and Jauan Jennings has 42 catches for 588 receiving yards as well on the year. On defense, Fred Warner has a team-high 78 total tackles including 47 solo tackles and 2 interceptions while Nick Bosa has 7 sacks. As a unit, San Francisco’s defense has combined for 26 sacks and 11 interceptions so far this season.

Why the San Francisco 49ers will win

  • The 49ers have won each of their last eight games following a home loss.
  • The Packers have lost three of their last four games following a road win.
  • The 49ers have covered the spread in seven of their last eight games following a home loss.
  • The Packers have failed to cover the spread in each of their last four games.

Green Bay Packers Recap

The Green Bay Packers come into this game looking to build on their 20-19 win over the Chicago Bears last time out to improve to 7-3 on the year. After this game, the Packers will head home to duke it out with the Miami Dolphins.

Packers Looking To Stay In NFC North Chase

Jordan Love has thrown for 2,081 yards, 16 touchdowns, and 11 interceptions on 62.3% passing while Josh Jacobs has rushed for 838 yards and 4 touchdowns on the year. Jayden Reed has a team-high 38 receptions for 643 yards and 4 touchdowns while Romeo Doubs has 31 grabs for 429 yards. Christian Watson and Tucker Kraft each have 350+ receiving yards as well on the year with Kraft logging 5 touchdowns. On defense, Quay Walker leads the Packers with 72 total tackles while Xavier McKinney has a team-high 6 interceptions. Rashan Gary also has a team-high 3.5 sacks as well on the year. As a team, Green Bay’s defense has combined for 25 sacks and 10 interceptions so far this season.

Why the Green Bay Packers will win

  • The Packers have won each of their last seven November home games against NFC West opponents.
  • The 49ers have lost each of their last three November games at Lambeau Field.
  • The Packers have covered the spread in 11 of their last 12 games against NFC West opponents.
  • The 49ers have failed to cover the spread in seven of their last eight games against teams that held a winning record.

49ers vs. Packers Prediction

I’m on the Packers here. I just think the Packers are in a better place when you compare them side-by-side with the 49ers, who truthfully, I haven’t been impressed with for much of anything for much of the year. Granted injuries are playing a part in that, but the Packers are the better team right now, at home laying less than a field goal. I’ll take it. Give me the Packers.

Chris Ruffolo's Pick: Green Bay -2.5

Need More? Get Premium Picks

Hot Cappers

Latest Picks & Game Previews

  • Burnley Burnley vs Manchester United Manchester United Prediction 8/30/2025 Today’s EPL Picks

    August 30, 2025

  • Everton Everton vs Wolverhampton Wanderers Prediction 8/30/2025 Today’s EPL Picks

    August 30, 2025

  • Bournemouth Bournemouth vs Tottenham Hotspur Tottenham Hotspur Prediction 8/30/2025 Today’s EPL Picks

    August 30, 2025

  • Brentford FC Brentford FC vs Sunderland Sunderland Prediction 8/30/2025 Today’s EPL Picks

    August 30, 2025

  • Texas vs Ohio State Prediction 8/30/2025 Today’s College Football Picks

    August 30, 2025

  • Florida Atlantic vs Maryland Prediction 8/30/2025 Today’s College Football Picks

    August 30, 2025

  • Merrimack vs Kent State Prediction 8/30/2025 Today’s College Football Picks

    August 30, 2025

  • Northwestern vs Tulane Prediction 8/30/2025 Today’s College Football Picks

    August 30, 2025

  • VMI vs Navy Prediction 8/30/2025 Today’s College Football Picks

    August 30, 2025

  • Duquesne vs Pittsburgh Prediction 8/30/2025 Today’s College Football Picks

    August 30, 2025