Aug 15, 2026; Kansas City, Missouri, USA; Los Angeles Rams quarterback Ty Simpson (15) drops back to pass during the second half against the Kansas City Chiefs at Arrowhead Stadium. Mandatory Credit: Jay Biggerstaff-Imagn Images
IMAGN IMAGES via Reuters Connect

Los Angeles Rams vs. New Orleans Saints Prediction 8/22/2026 Today’s NFL Picks

Pick details

Los Angeles Rams vs. New Orleans Saints

04:00 PM EDT

The Line: Betting Odds: New Orleans Saints -1 — Over/Under: 37

(Get latest betting odds)


The New Orleans Saints and the Los Angeles Rams meet in week 2 NFL preseason action from SoFi Stadium on Saturday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a New Orleans Saints vs. Los Angeles Rams Prediction.

New Orleans Saints Recap

The New Orleans Saints come into this game looking to bounce back from a 24-20 loss to Jacksonville in their preseason opener to sit at 0-1. After this game, the Saints will close out the preseason with a game against the Dallas Cowboys.

Saints Looking To Get In Win Column

Zach Wilson threw for 145 yards and a touchdown on 11 of 16 passing while Hunter Dekkers threw for 69 yards on 8 of 15 passing and Spencer Rattler had 42 passing yards on 8 of 11 passing. Audric Estime led the Saints in rushing with 28 yards and a TD on 5 carries while Ty Chandler added 24 rushing yards on 6 carries. Bub Means added 4 catches for 77 yards while Barion Brown added 4 grabs for 53 yards and Jalen Moreno-Cropper added 49 receiving yards. Trey Palmer had 4 grabs for 33 yards and Oscar Delp added a receiving TD as well in the loss. On defense, Dalys Beanum had a team-high 11 total tackles including 6 solo tackles while Jaylan Ford and Jackson Sirmon each had 8 total tackles. Michael Heldman had a pair of sacks and Garrett Nelson and Fadil Diggs each had a sack. Jaylan Ford and Jayden Price each had an INT as well for the Saints in the loss.

Los Angeles Rams Recap

The Los Angeles Rams come into this game looking to add on to their 20-12 win over the Kansas City Chiefs last time out to start the preseason 1-0. After this game, the Rams will take on the Chargers to close out the preseason.

Rams Looking To Add On Solid Debut

Ty Simpson threw for 190 yards and 2 TDs on 21 of 25 passing while Stetson Bennett IV had 38 yards passing on 4 of 6. Jordan Waters added 37 rushing yards to lead the Rams while Jarquez Hunter had 9 carries for 35 yards and Dean Connors added 6 carries for 22 yards. Brennan Presley led the Rams in receiving with 4 grabs for 58 yards while Mark Redman added 3 catches for 47 yards and Max Klare added 7 grabs for 37 yards. Connors also had 4 catches for 29 yards and a pair of TDs for the Rams’ receiving group. On defense, Nick Andersen added 9 total tackles while Tim Keenan III and Desjuan Johnson each had a sack in the win.

New Orleans Saints vs. Los Angeles Rams Prediction

I’m on the Rams here. I was really impressed with the Rams in their opener and I just don’t have the faith for the Saints in this matchup against a Rams team that looks like they’re firing on all cylinders out of the gate this season. I do like the Saints long term, but in this matchup, I have to back the Rams here.

Chris Ruffolo's Pick: LA Rams +1

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