Sep 14, 2025; Baltimore, Maryland, USA; Baltimore Ravens running back Derrick Henry (22) is tackled by Cleveland Browns defensive end Myles Garrett (95) during the first quarter at M&T Bank Stadium. Mandatory Credit: Peter Casey-Imagn Images

Detroit Lions vs Baltimore Ravens Prediction 9/22/2025 Today’s NFL Picks

Pick details

Detroit (1-1) vs Baltimore (1-1)

September 22, 2025 at 08:15 PM EDT

The Line: Betting Odds: Baltimore -4.5 — Over/Under: +51.5

(Get latest betting odds)

The Detroit Lions and Baltimore Ravens meet Monday in NFL action at M&T Bank Stadium. Here’s a Detroit Lions vs Baltimore Ravens Prediction. This article will include a Detroit Lions vs Baltimore Ravens Pick.

Detroit Lions Betting Preview


The Detroit Lions lost to the Packers, beat the Bears, and play the Browns next. The Detroit Lions have won 15 of their last 17 regular season games. Jared Goff is completing 80.6 percent of his passes for 559 yards, 6 touchdowns, and 1 interception. Amon-Ra St. Brown and Jameson Williams have combined for 291 receiving yards and 4 touchdowns, while Sam LaPorta has 9 receptions.

The Detroit Lions ground game is averaging 111.5 yards per contest, and Jahmyr Gibbs leads the way with 113 yards and 1 touchdown. Defensively, Detroit is allowing 24 points and 302.5 yards per game. Jack Campbell leads the Detroit Lions with 18 tackles, Aidan Hutchinson has 1 sack and Kerby Joseph has 1 interception.

Baltimore Ravens Betting Preview


The Baltimore Ravens lost to the Bills, beat the Browns, and they play the Chiefs next. The Baltimore Ravens have won 5 of their last 6 regular season games. Lamar Jackson is completing 68.8 percent of his passes for 434 yards, 6 touchdowns, and 0 interceptions. Zay Flowers and DeAndre Hopkins have combined for 317 receiving yards and 3 touchdowns, while Devontez Walker has 2 receptions.

The Baltimore Ravens ground game is averaging 141.5 yards per contest, and Derrick Henry leads the way with 192 yards and 2 touchdowns. Defensively, Baltimore is allowing 29 points and 409.5 yards per game. Roquan Smith leads the Baltimore Ravens with 25 tackles, Nnamdi Madubuike has 2 sacks and Nate Wiggins has 1 interception.

Detroit Lions @ Baltimore Ravens Betting Trends: Week 3


Why the Baltimore Ravens will win

  • The Ravens have won eight of their last nine home games.
  • The Lions have lost five of their last six road games against AFC North opponents.
  • The Ravens have covered the spread in each of their last four home games.
  • The Lions have lost the first half in four of their last five games against AFC North opponents.
  • The Lions have lost the first quarter in six of their last seven road games.

Why the Detroit Lions will win

  • The Lions have won seven of their last eight games against AFC opponents.
  • The Ravens have lost each of their last two Week 3 games as home favorites.
  • The Lions have covered the spread in each of their last seven Week 3 games.
  • The Ravens have failed to cover the spread in six of their last seven games at M&T Bank Stadium following a home win.
  • The Ravens have lost the first half in three of their last four Week 3 games at M&T Bank Stadium.
  • The Lions have won the first quarter in each of their last three September games as road underdogs against AFC opponents.

Total Points Facts

  • Six of the Ravens’ last seven games against NFC opponents have gone OVER the total points line.
  • Four of the Lions’ last five games following a win have gone OVER the total points line.

Baltimore Ravens Player Prop Facts

  • Derrick Henry has scored two touchdowns in three of the Ravens’ last four September games as favorites.
  • Derrick Henry has scored at least one touchdown in each of the Ravens’ last seven games as favorites following a home win.
  • DeAndre Hopkins has recorded 18+ receiving yards in each of his 32 previous appearances with his team as a favorite against NFC opponents.
  • Derrick Henry has recorded 111+ rushing and receiving yards in five of the Ravens’ last six games following a win.
  • Lamar Jackson has recorded 237+ passing yards in each of the Ravens’ last four games against NFC opponents.
  • Lamar Jackson has recorded 58+ rushing yards in each of the Ravens’ last five Week 3 games.
  • Lamar Jackson has recorded 18+ completions in each of the Ravens’ last seven games at M&T Bank Stadium with a total points line of at least 50.0.
  • Heading into Week 3, Lamar Jackson ranks 1st amongst qualified players for passer rating (136.6) this season.

Detroit Lions Player Prop Facts

  • Jahmyr Gibbs has scored two or more touchdowns in three of the Lions’ last four games following a win.
  • David Montgomery has scored at least one touchdown in each of his last six road appearances with a total points line of at least 50.0.
  • Kalif Raymond has recorded 11+ receiving yards in each of the Lions’ last 14 regular season games as underdogs.
  • David Montgomery has recorded 65+ rushing and receiving yards in each of his last eight appearances with his team as an underdog following a win.
  • Jared Goff has recorded 253+ passing yards in eight of the Lions’ last nine road games with a total points line of at least 50.0.
  • David Montgomery has recorded 53+ rushing yards in seven of his last eight appearances with his team as an underdog following a win.
  • Jared Goff has recorded 23+ completions in each of the Lions’ last seven regular season games.
  • Heading into Week 3, Amon-Ra St. Brown ranks T1st in the NFL in receiving touchdowns (3) this season.

Matchup/League Facts

  • Ravens – two different players have recorded 50+ rushing yards in a game this season – equal-most in the NFL, heading into Week 3.
  • Ravens – two different players have recorded 60+ rushing yards in a game this season – equal-most in the NFL, heading into Week 3.
  • Lions – one different players have recorded 90+ rushing yards in a game this season – equal-most in the NFL, heading into Week 3.
  • Lions – three different players have recorded 60+ receiving yards in a game this season – equal-most in the NFL, heading into Week 3.

Detroit Lions vs Baltimore Ravens Prediction

The Ravens are going to be favored at home, as you can make a case they’re the best team in the league. I wouldn’t talk you off the ledge if looking at the Ravens and the reasonable number. However, the Lions are a good team in their own right despite what a rocky start has shown, and you’re not going to get them as an underdog often. The Lions have also covered 10 of their last 12 games as an underdog, and 7 of those covers were outright wins. The Lions have covered 8 of their last 9 games when an underdog of 3 or more points. As high as I am on the Ravens, I just can’t leave this many points on the table with the Lions, a talented team that’s been Super Bowl caliber for the last few years. Give me the points.

Randy Chambers's Pick: Detroit Lions +4.5

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