Chicago Bears vs San Francisco 49ers Prediction 12/28/2025 Today’s NFL Picks

The Chicago Bears and the San Francisco 49ers meet Sunday in NFL action from Levi’s Stadium in Santa Clara. Here’s a Bears vs 49ers prediction. We will look at this from a betting perspective and determine the best Bears vs 49ers pick. We will examine the recent form and player performances for both teams, as well as the recent betting trends and streaks pertaining to this matchup. As we conclude, we will tie it all together with a summary that produces a sensible pick for a favorable betting outcome in this game.

Chicago Bears Betting Preview

The Bears limped into their early bye week with a 2-2 record, beating the Cowboys and Raiders after losses to the Vikings and Lions. Since then Chicago has lost only two games versus the Ravens and Packers. The wins otherwise have come versus the Commanders, Saints, Bengals, Giants, Vikings, Steelers, Eagles, Browns and Packers. That gives Chicago an 11-4 overall record this year.

In the Packers game last Saturday the Bears were down 6-0 after the first half. Chicago rallied with 13 fourth-quarter points to force overtime and eventually won it 22-16 in the end. QB Caleb Williams went 19-of-34 for 250 yards and two scores while D’Andre Swift had 13 carries for 58 yards. DJ Moore added five catches for 97 yards and a touchdown in the winning effort.

San Francisco 49ers Betting Preview

Over on the Niners’ side, they opened the year at 6-4 with losses to the Jaguars, Bucs, Texans and Rams. The wins otherwise came versus the Seahawks, Saints, Cardinals, Rams, Falcons, Giants, Cardinals, Panthers and Browns. After the bye week, San Francisco took out Tennessee to make for a 10-4 overall record across their first 14 games.

In the Monday matchup versus Indianapolis, the 49ers scored double-digit points in every quarter on the way to a 48-27 win in the end. QB Brock Purdy finished with a 25-of-34 line for 295 yards, five scores and one pick. Christian McCaffrey added 21 carries for 117 yards with two receiving scores and George Kittle had 115 yards and a score off seven catches in the winning effort for the Niners.

Chicago Bears @ San Francisco 49ers Betting Trends: Week 17

Why the San Francisco 49ers will win

• The Bears have lost each of their last nine road games against NFC opponents on a winning streak.
• The 49ers have won each of their last eight games as favorites without Brayden Willis.
• The Bears have failed to cover the spread in each of their last five games as underdogs in California.
• The home team has covered the spread in each of the Bears’ last four Week 17 games.
• The Bears have lost the first quarter in each of their last four games against NFC West opponents.
• The Bears have lost the first half in each of their last eight road games against NFC West opponents.

Why the Chicago Bears will win

• The Bears have won seven of their last eight games.
• The 49ers have lost each of their last two games as favorites without Christian McCaffrey.
• The 49ers have failed to cover the spread in 13 of their last 14 games at Levi’s Stadium following a win.
• The Bears have covered the spread in five of their last six games.

Total Points Facts

• Each of the 49ers’ last four games in December have gone OVER the total points line.
• Six of the Bears’ last seven Sunday games as road underdogs have gone OVER the total points line.

San Francisco 49ers Player Prop Facts

• Christian McCaffrey has scored at least one touchdown in each of his last six appearances in home night games against teams that held a winning record.
• Christian McCaffrey has recorded 107+ rushing and receiving yards in each of his eight previous appearances in games with a total points line of at least 50.0.
• Brock Purdy has recorded 252+ passing yards in each of the 49ers’ last five games as favorites against NFC North opponents.
• George Kittle has recorded 68+ receiving yards in each of his last eight appearances with the 49ers as favorites following a road win.
• Christian McCaffrey has scored two touchdowns in each of his three previous appearances with the 49ers as favorites against NFC North opponents.
• Brian Robinson has recorded 24+ rushing yards in each of his seven previous December appearances against NFC opponents.
• Brock Purdy has recorded 22+ completions in each of his last four appearances at Levi’s Stadium.
• Heading into Week 17, Ji’Ayir Brown has recorded the equal-most interceptions in a single game this season (2 vs Panthers, Week 12).

Chicago Bears Player Prop Facts

• D’Andre Swift has scored a touchdown in six of his last eight road appearances.
• D’Andre Swift has recorded 70+ rushing and receiving yards in nine of his last 10 appearances.
• D’Andre Swift has recorded 15+ receiving yards in 18 of his last 20 appearances in games with a total points line of at least 50.0.
• D’Andre Swift has recorded 63+ rushing yards in each of the Bears’ last seven road games against NFC opponents.
• Caleb Williams has recorded 19+ completions in six of the Bears’ last seven Sunday road games.
• Heading into Week 17, Kevin Byard has recorded the equal-most interceptions in a single game this season (2 vs Raiders, Week 4).

Matchup/League Facts

• Heading into Week 17, the 49ers rank 32nd in the NFL in average yards per punt (43.6) this season.
• Heading into Week 17, the 49ers have recorded the equal-most wins by a margin of 10+ points this season (7).
• Bears – two different players have recorded 100+ rushing yards in a game this season – equal-most in the NFL, heading into Week 17.
• Heading into Week 17, the Bears rank 1st in the NFL in interceptions (21) this season.

Bears vs 49ers Prediction

I’m going to take a stab on the Bears. Chicago keeps chugging along this year, and they’re coming off a thriller win versus the rival Packers. In that one the Bears amassed 400 yards with 6.7 yards per play and 20 first downs with no turnovers. That said, Chicago was also pretty bad on third downs (2-of-11) and had 10 penalties as a team in the OT victory. Still, the Bears are in control of the NFC North and are looking great with just two more games left until the postseason. Chicago is a nice 7-1 over their last eight games.

As for the Niners, they didn’t have much issue with a depleted Colts team over the weekend. San Francisco’s defense held Indy to 312 yards, 58 rush yards, 19 first downs, 5-of-10 on third downs and had two takeaways. The offense put up 440 yards on the other side with a nice 7-of-11 on third downs. That makes five straight wins for San Francisco, and a whopping 85 points in two games since the bye. The 49ers will be a formidable opponent for the Bears; this should be a great matchup all around.

Andrew Jett's Pick: Chicago Bears +3