Buffalo Bills vs Cleveland Browns Prediction 12/21/2025 Today’s NFL Picks

The Buffalo Bills and the Cleveland Browns meet in week 16 NFL action from Huntington Bank Field on Sunday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Buffalo Bills vs. Cleveland Browns prediction.

Buffalo Bills Recap

The Buffalo Bills come into this game looking to add on to their 35-31 win over New England last time out to improve to 10-4 this season. After this game, Buffalo will head home for a game against the Philadelphia Eagles.

Bulls Win 3 In A Row

Josh Allen has thrown for 3,276 yards, 25 touchdowns and 10 interceptions on 70% passing while also rushing for 535 yards and 12 scores. James Cook has a team-high 1,415 rushing yards and 10 touchdowns while Khalil Shakir has a team-high 62 catches for 650 yards and 4 TDs. Dalton Kincaid has 523 receiving yards,5 touchdowns and 36 receptions and Keon Coleman has 36 catches for 355 yards and 4 TDs. On defense, Cole Bishop leads the Bills with 76 total tackles along with 3 interceptions while Joey Bosa has 5 sacks and the Bills’ defense as a whole has combined for 31 sacks and 11 interceptions so far this season.

Cleveland Browns Recap

The Cleveland Browns come into this game looking to bounce back from their 31-3 loss at the hands of Chicago last time out to sit at 3-11 this season. After this game, Cleveland will take on the Pittsburgh Steelers at home.

Browns Lose 3 In A Row

Dillon Gabriel has thrown for 937 yards, 7 touchdowns and 2 INTs on 59.2% passing while Shedeur Sanders has thrown for 946 yards, 5 touchdowns and 6 INTs on 52.2% passing. Quinshon Judkins has rushed for a team-high 805 yards and 7 touchdowns this season. Harold Fannin Jr. leads the Browns with 66 catches for 667 yards while Jerry Jeudy has 519 receiving yards and David Njoku has 293 receiving yards. Two more Browns have 200+ receiving yards as well on the year. On defense, Carson Schwesinger has a team-high 133 total tackles while Devin Bush has 93 total tackles including 59 solo tackles. Myles Garrett has a team-high 21.5 sacks and Maliek Collins has 6.5 sacks. As a unit, Cleveland’s defense has combined for 47 sacks and 10 interceptions so far this season. 

Buffalo Bills @ Cleveland Browns Betting Trends: Week 16

Why the Cleveland Browns will win

• The Bills have lost each of their last two games as heavy favorites (>-7.0 points).
• The Browns have won 10 of their last 14 home games against teams that held a winning record.
• The Bills have failed to cover the spread in each of their last four road games without Dawson Knox.
• The Browns have covered the spread in each of their last four games at Huntington Bank Field following a road loss.
• The Browns have scored the first touchdown in six of their last seven games against AFC East opponents.
• The underdogs have won the first quarter in each of the Bills’ last four Week 16 games.
• The Bills have lost the first half in each of their last six games as favorites against AFC opponents.

Why the Buffalo Bills will win

• The Bills have won each of their last 11 December games against AFC opponents.
• The Browns have lost each of their last eight games against AFC opponents on a winning streak.
• The Browns have failed to cover the spread in each of their last 10 games as underdogs without Cedric Tillman.
• The Bills have covered the spread in six of their last seven December road games against AFC opponents.
• The Browns have lost the first quarter in each of their last five games in December.
• The Browns have lost the first half in each of their last 11 Sunday games against teams that held a winning record.

Total Points Facts

• Each of the Browns’ last eight Week 16 games as underdogs have gone UNDER the total points line.
• Each of the Bills’ last six road games against AFC North opponents have gone UNDER the total points line.
• Three of the last four Sunday games at Huntington Bank Field have gone OVER the total points line.

Cleveland Browns Player Prop Facts

• Harold Fannin Jr. has scored a touchdown in each of the Browns’ last two home games.
• Shedeur Sanders has recorded 16+ rushing yards in three of the Browns’ last four games following a loss.
• Shedeur Sanders has recorded 16+ completions in each of the Browns’ last three games.
• Quinshon Judkins has recorded 84+ rushing and receiving yards in four of the Browns’ last five games at Huntington Bank Field.
• Cedric Tillman has recorded 23+ receiving yards in each of his last seven home appearances against AFC opponents.
• Heading into Week 16, Quinshon Judkins has recorded the equal-most rushing touchdowns in a single game this season (3 vs Dolphins, Week 7).

Buffalo Bills Player Prop Facts

• Josh Allen has scored two or more touchdowns in three of the Bills’ last four December road games.
• Josh Allen has recorded 19+ completions in each of the Bills’ last six games following a win.
• Josh Allen has recorded 38+ rushing yards in each of the Bills’ last four Sunday games.
• Josh Allen has recorded 213+ passing yards in seven of the Bills’ last eight games following a road win.
• James Cook has scored at least one touchdown in each of the Bills’ last six games against teams on a losing streak.
• Dawson Knox has recorded 28+ receiving yards in each of his seven previous regular season appearances with the Bills as favorites against AFC North opponents.
• Brandin Cooks has recorded 50+ rushing and receiving yards in six of his last eight appearances with his team as a road favorite against AFC opponents.
• Heading into Week 16, Josh Allen is the only player in the NFL to record 2,000 passing yards and 500 rushing yards this season.

Matchup/League Facts

• Heading into Week 16, the Browns rank 1st in the NFL in passing yards allowed per game (169.0) this season.
• Heading into Week 16, the Browns rank 1st in the NFL in total punt yards (3609) this season.
• Bills – eight different players have recorded 60+ receiving yards in a game this season – most in the NFL, heading into Week 16.
• Bills – five different players have recorded 90+ receiving yards in a game this season – equal-most in the NFL, heading into Week 16.

Buffalo Bills vs. Cleveland Browns Prediction

I’m on the Bills in this one. I will admit that the matchup of Myles Garrett going after Josh Allen does give me some pause for the Bills QB, but I still think that Allen has the better offense behind him and at the end of the day, I don’t trust Shedeur Sanders and this Browns offense right now to keep this team in games, especially against a Buffalo team that’s still fighting for their division. I think there’s a clear division in talent here and I think Buffalo gets it done here.

Chris Ruffolo's Pick: Buffalo -10.5