Portland Trail Blazers vs San Antonio Spurs Prediction 4/21/2026 Today’s NBA Picks

The Portland Trail Blazers and San Antonio Spurs meet Tuesday in NBA Game 2 at the Frost Bank Center. Here’s a Portland Trail Blazers vs. San Antonio Spurs Prediction. This article will include a Portland Trail Blazers vs. San Antonio Spurs Pick.

Portland Trail Blazers Betting Preview

The Portland Trail Blazers need a win to even up the series at 1-1. The Trail Blazers have won 20 of their last 33 games.

The Portland Trail Blazers are averaging 98 points on 42.9 percent shooting and allowing 111 points on 47.6 percent shooting. Deni Avdija is averaging 30 points and 10 rebounds, while Scoot Anderson is averaging 18 points and 3 rebounds. Robert Williams III is the third double-digit scorer, and Shaedon Sharpe is grabbing 1 rebound. The Portland Trail Blazers are shooting 26.3 percent from beyond the arc and 83.3 percent from the free-throw line. The Portland Trail Blazers are allowing 45.5 percent shooting from deep and are grabbing 38 rebounds per game.

San Antonio Spurs Betting Preview

The San Antonio Spurs have a chance to take a quick 2-0 series lead. The Spurs have won 36 of their last 44 games.

The San Antonio Spurs are averaging 111 points on 47.6 percent shooting and allowing 98 points on 42.9 percent shooting. Victor Wembanyama is averaging 35 points and 5 rebounds, while De’Aaron Fox is averaging 17 points and 8 assists. Stephon Castle is the third double-digit scorer, and Devin Vassell is dishing 2 assists. The San Antonio Spurs are shooting 45.5 percent from beyond the arc and 84.2 percent from the free throw line. The San Antonio Spurs are allowing 26.3 percent shooting from deep and are grabbing 45 rebounds per game.

Why the San Antonio Spurs will win

• The Trail Blazers have lost each of their last 16 playoff road games against Southwest Division opponents following a loss.
• The Spurs have won 30 of their last 32 night games.
• The Trail Blazers have failed to cover the spread in each of their last 10 playoff games as road underdogs against Southwest Division opponents.
• The favorites have covered the spread in eight of the last nine games between the Trail Blazers and Spurs at Frost Bank Center.

Why the Portland Trail Blazers will win

• The Spurs have lost three of their last four playoff games as home favorites following a win.
• The Trail Blazers have won six of their last seven games against Western Conference opponents following a loss.
• The Trail Blazers have covered the spread in four of their last five games following a loss.
• The Spurs have failed to cover the spread in six of their last eight home games against Northwest Division opponents following a win.

Total Points Facts

• Ten of the Spurs’ last 11 playoff games as favorites have gone OVER the total points line.
• Each of the Trail Blazers’ last five night games against Southwest Division opponents has gone UNDER the total points line.

San Antonio Spurs Player Facts

• Julian Champagnie is one of only 11 players in the league to have made 10+ threes in a game this season.
• Keldon Johnson is one of only 11 qualified Guards in the league shooting at least 50% from the field this season.

Portland Trail Blazers Player Facts

• Jrue Holiday is one of only four players in the league to have made 7+ threes in consecutive games this season.
• Toumani Camara ranks 31st amongst qualified players for three-pointers made per game (2.7) this season.

Matchup/League Facts

• The Spurs rank 1st in the league for Q1 win percentage this season (69.5%).
• The Spurs rank 2nd in the league for point differential per game this season (+8.3).
• The Trail Blazers rank 1st for second chance points (1513) this season.
• The Trail Blazers rank 1st for second chance points per game (18.5) this season.

Portland Trail Blazers vs San Antonio Spurs Injury Report

David Jones Garcia and Jordan McLaughlin are out for the Spurs.

The Trail Blazers will be without Damian Lillard.

Portland Trail Blazers vs San Antonio Spurs Prediction

The Spurs looked good in their first playoff game and I’m high on this team. I actually like the Spurs to win it all, so I’m not surprised by this number. However, the Trail Blazers never went away in game 1 and even had their chance at a backdoor cover. I’d expect a better effort here now with a game out of the way. If anything, it’s the two vets that need to be better, as Jrue Holiday and Jerami Grant weren’t great. The Trail Blazers are a feisty team that fights for 48 minutes, and I’m not willing to leave this many points on the table. The Spurs will make this a quick series overall but the Trail Blazers can hang within the big numbers. This isn’t a trash team. Give me the points.

Randy Chambers's Pick: Portland Trail Blazers +11.5