White Sox vs Brewers Prediction 3/26/2026 Today’s MLB Picks

In this article we will formulate a White Sox vs Brewers prediction for this MLB game on Thursday, March 26th at American Family Field in Milwaukee, Wisconsin. Let’s take a look at the prediction for this MLB matchup. 

Chicago White Sox Betting Preview

The Chicago White Sox went 60-102 last season and they finished last in the AL Central standings, 28 games behind Cleveland for first. Chicago started the season with an 8-1 win over the Angels, but they lost two out of three in that opening series. The White Sox struggled right out of the gate last year, but they did play decently well in June and started September by winning eight of their first ten games. Chicago went 33-48 at home and 27-54 on the road, while they scored 647 runs and allowed 742 runs during the season. 

Last year, Chicago had a 4.26 ERA with a 1.36 WHIP and a .248 opponent batting average, while they scored 647 runs with a .232 batting average and a .302 on base percentage. Lenyn Sosa led the team with 22 home runs and 75 RBIs, while Andrew Benintendi added 20 home runs and 63 RBIs last year. The projected starting pitcher for Chicago is Shane Smith, who went 7-8 with a 3.81 ERA and a 1.20 WHIP over 146.1 innings pitched last season. 

Milwaukee Brewers Betting Preview

The Milwaukee Brewers were 97-65 last year and they finished first in the NL Central, five games up on St. Louis for second. Milwaukee started the season with a 4-2 loss against the Yankees and they lost all three of their games in that series. The Brewers started with an 0-4 record in March, but they bounced back and ended up pulling away in the NL Central standings. Milwaukee had a first round bye in the postseason and they defeated the Cubs in five games in the NLDS, but they were swept by the Dodgers in the NLCS. The Brewers went 52-29 at home and 45-36 on the road, while they scored 806 runs and allowed 634 last year. 

Last season, Milwaukee had a 3.58 ERA with a 1.23 WHIP and a .230 opponent batting average, while they scored 806 runs with a .258 batting average and a .332 on base percentage. Christian Yelich led the team with 29 home runs and 103 RBIs, while Brice Turang added 18 home runs and 81 RBIs. The projected starting pitcher for Milwaukee is Jacob Misiorowski, who went 5-3 with a 4.36 ERA and a 1.24 WHIP over 66.0 innings pitched last year. 

Why the Milwaukee Brewers will win

• The Brewers have won each of their last six home games against American League opponents.
• The White Sox have lost six of their last seven road openers.
• The Brewers have covered the run line in each of their last four games against AL Central opponents.
• The White Sox have trailed after 3 innings in seven of their last nine road openers as underdogs.
• The Brewers have led after 5 innings in each of their last four games against AL Central opponents.

Why the Chicago White Sox will win

• The White Sox have won four of their last six games as underdogs against NL Central opponents.
• The Brewers have lost six of their last seven games.
• The White Sox have covered the run line in each of their last nine road games against National League opponents.
• The Brewers have failed to cover the run line in each of their last six Thursday day games against American League opponents.
• The Brewers have trailed after 5 innings in each of their last three season openers as favorites.

Total Runs Facts

• Four of the Brewers’ last five games against American League opponents have gone OVER the total runs line.
• Three of the White Sox’s last four road games against NL Central opponents have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in seven of the Brewers’ last eight games as home favorites against American League opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in six of the White Sox’s last seven road games against NL Central opponents.

Milwaukee Brewers Player Prop Facts

• William Contreras has hit a home run in each of the Brewers’ last two games as home favorites.
• Gary Sanchez has recorded at least one hit in 14 of his last 15 appearances with his team as a favorite against AL opponents.

Chicago White Sox Player Prop Facts

• Miguel Vargas has hit a home run in each of his last two appearances at American Family Field.
• Miguel Vargas has recorded at least one hit in each of the White Sox’s last nine games as underdogs.

White Sox vs Brewers Prediction 

Chicago comes into this season looking to start on the right foot, as they have been pretty bad over the last few seasons. The White Sox do have Shane Smith on the mound, but their offense is expected to be low scoring. Milwaukee won the NL Central last season and they will be looking for a strong start from Misiorowski, who was very hot and cold in limited work last year. I like the pitching matchup in this game and with Chicago likely to struggle, I will take the under here.

David Racey's Pick: Under 8