Twins vs White Sox Prediction 5/27/2026 Today’s MLB Picks

In this article we will formulate a Twins vs White Sox prediction for this MLB game on Wednesday, May 27th at Rate Field in Chicago, Illinois. Let’s take a look at the prediction for this MLB matchup. 

Minnesota Twins Betting Preview

The Minnesota Twins are 27-28 this year after they split the first two games in this series by scores of 1-3 and 5-3. In game two, Minnesota blew a 2-0 lead in the eighth inning, but they scored three runs in the 11th for the win. The Twins recorded seven hits in the game and they were led by Lee, who went 2-5 with three RBIs. Ryan allowed five hits and two earned runs over 7.2 innings, while Rogers picked up the win and Gomez got the save. Prior to this series, Minnesota swept the Red Sox in three games and won two out of three against the Astros. 

This season, Minnesota has a 4.12 ERA with a 1.30 WHIP and a .240 opponent batting average, while they have scored 254 runs with a .238 batting average and a .322 on base percentage. Byron Buxton has led the Twins with 16 home runs and 26 RBIs, while Josh Bell has added five home runs and 29 RBIs. The projected starting pitcher for Minnesota is Connor Prielipp, who is 1-2 with a 4.03 ERA and a 1.17 WHIP over 29.0 innings pitched this year. 

Chicago White Sox Betting Preview

The Chicago White Sox are 27-27 this season after they lost game two by a score of 5-3 last night. Chicago finally found some offense in the eighth inning, but they failed to score in the 10th and lost in the 11th. The White Sox recorded eight hits in the game and they were led by Murakami, who went 1-5 with one home run and two RBIs. Burke allowed three hits and two earned runs over 7.0 innings, while Davis picked up the loss in extras. Prior to this series, Chicago lost two out of three against the Giants and two out of three against the Mariners. 

This season, Chicago has a 4.45 ERA with a 1.35 WHIP and a .241 opponent batting average, while they have scored 241 runs with a .231 batting average and a .320 on base percentage. Munetaka Murakami has led the White Sox with 19 home runs and 39 RBIs, while Colson Montgomery has added 13 home runs and 32 RBIs. The projected starting pitcher for Chicago is David Sandlin, who is making his first appearance in the MLB this season. 

Why the Chicago White Sox will win

• The White Sox have won seven of their last eight night games following a loss.
• The Twins have lost each of their last six Wednesday road games.
• The White Sox have covered the run line in seven of their last eight home games against American League opponents after playing the previous day.
• The Twins have failed to cover the run line in each of their last four night games at Rate Field following a road win.
• The Twins have trailed after 5 innings in nine of their last 12 road night games.

Why the Minnesota Twins will win

• The Twins have won five of their last six games as underdogs against American League opponents.
• The White Sox have lost nine of their last 12 games as home favorites after going to extra innings.
• The White Sox have failed to cover the run line in each of their last seven games as home favorites following an extra innings loss.
• The Twins have covered the run line in eight of their last nine games as underdogs following a road win.
• The Twins have led after 5 innings in three of their last four games against the White Sox.

Total Runs Facts

• Each of the White Sox’s last four night games against AL Central opponents have gone OVER the total runs line.
• Five of the Twins’ last six games following an extra innings win have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Twins’ last five games as underdogs.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the White Sox’s last four games as home favorites against American League opponents.

Twins vs White Sox Prediction 

Minnesota was able to get back on the right track with a win on Tuesday night and they have won five of their last six games. The Twins are 12-14 on the road this year, while the White Sox are 15-11 at home. Chicago has dropped three of their last four games and they have allowed 23 runs in those three losses. The White Sox are starting Sandlin, who is making his first appearance of the year, while Prielipp has allowed two earned runs or fewer in four of his last five outings. This pitching matchup makes me nervous and I think we will see plenty of scoring, so I like the over here.

David Racey's Pick: Over 8