Twins vs White Sox Prediction 5/25/2026 Today’s MLB Picks

In this article we will formulate a Twins vs White Sox prediction for this MLB game on Monday, May 25th at Rate Field in Chicago, Illinois. Let’s take a look at the prediction for this MLB matchup. 

Minnesota Twins Betting Preview

The Minnesota Twins are 26-27 this year after they swept the Red Sox in three games by scores of 8-6, 4-2, and 6-5. In game three, Minnesota trailed 4-3 in the fourth inning, but they scored the next three runs and hung on for the close win. The Twins recorded 12 hits and they committed one error in the game, while they were led by Lee, who went 2-4 with two RBIs. Ober allowed seven hits and four earned runs over 5.0 innings for the win, while Adams picked up the save. Prior to that series, Minnesota won two out of three against the Astros, but lost two out of three against the Brewers before that. 

This season, Minnesota has a 4.19 ERA with a 1.32 WHIP and a .242 opponent batting average, while they have scored 248 runs with a .240 batting average and a .325 on base percentage. Byron Buxton has led the Twins with 16 home runs and 26 RBIs, while Josh Bell has added five home runs and 30 RBIs. The projected starting pitcher for Minnesota is Zebby Matthews, who is 1-1 with a 1.38 ERA and a 0.77 WHIP over 13.0 innings pitched this year. 

Chicago White Sox Betting Preview

The Chicago White Sox are 26-26 this season after they lost two out of three against the Giants by scores of 9-4, 3-10, and 5-8. In game three, Chicago erased a 4-1 deficit in the fifth inning, but they allowed a grand slam in the bottom of the fifth in the loss. The White Sox recorded four hits and they committed one error, while they were led by Vargas, who went 1-3 with one home run and one RBI in the game. Schultz allowed six hits and six earned runs over 4.0 innings for the loss, while Taylor allowed two earned runs in relief. Prior to that series, Chicago lost two out of three against the Mariners, but did win two out of three against the Cubs before that. 

This season, Chicago has a 4.54 ERA with a 1.37 WHIP and a .243 opponent batting average, while they have scored 235 runs with a .232 batting average and a .322 on base percentage. Munetaka Murakami has led the White Sox with 17 home runs and 36 RBIs, while Colson Montgomery has added 13 home runs and 32 RBIs. The projected starting pitcher for Chicago is Anthony Kay, who is 3-1 with a 4.27 ERA and a 1.45 WHIP over 46.1 innings pitched this season. 

Why the Chicago White Sox will win

• The underdogs have won each of the last six games between the Twins and White Sox.
• The Twins have lost eight of their last nine games as road favorites against American League opponents.
• The White Sox have covered the run line in each of their last six games as underdogs against the Twins.
• The Twins have failed to cover the run line in eight of their last nine games as road favorites against American League opponents.
• The White Sox have led after 3 innings in five of their last six home games against AL Central opponents that held a losing record.
• The Twins have trailed after 5 innings in each of their last four games as road favorites against AL Central opponents.

Why the Minnesota Twins will win

• The Twins have won seven of their last eight games against AL Central opponents.
• The White Sox have lost eight of their last nine home games following a road loss.
• The Twins have covered the run line in seven of their last eight games against AL Central opponents.
• The White Sox have failed to cover the run line in eight of their last nine home games following a road loss.
• The White Sox have trailed after 5 innings in four of their last five day games against opponents that held a losing record.

Total Runs Facts

• Each of the White Sox’s last six games as home underdogs have gone OVER the total runs line.
• Each of the Twins’ last five games as road favorites have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in eight of the White Sox’s last nine home games.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of Zebby Matthews’ last five road appearances as a starter.

Chicago White Sox Player Prop Facts

• Miguel Vargas has hit a home run in two of the White Sox’s last three games at Rate Field.
• Miguel Vargas has recorded at least one hit in each of the White Sox’s last 12 games at Rate Field.
• Colson Montgomery ranks T10th in the league in Home Runs (13) this season.

Minnesota Twins Player Prop Facts

• Byron Buxton has hit a home run in three of his last five road appearances against AL opponents.
• Byron Buxton has recorded at least one hit in each of his last six road appearances.
• Austin Martin ranks 4th amongst qualified players for On Base Percentage (.406) this season.

Matchup/League Facts

• The White Sox rank 3rd in the league for home runs this season (70).
• The White Sox rank 26th in the league for strikeouts against this season (485).
• The Twins rank 25th in the league for strikeouts this season (407).
• The Twins rank 7th in the league for runs scored this season (248).

Twins vs White Sox Prediction 

Minnesota comes into this matchup on a four game winning streak and they have scored 22 runs during those four wins. The Twins are 11-13 on the road this year, while the White Sox are 14-10 at home. Chicago has dropped three of their last four games and they have allowed 18 runs in their last two. The White Sox are starting Kay, who has allowed two earned runs or fewer in four straight starts, while Matthews has allowed two earned runs over 13.0 innings in two starts. Minnesota is hot right now, but Kay has shown a lot of improvement and I like the White Sox at home.

David Racey's Pick: White Sox ML