Jun 17, 2025; Toronto, Ontario, CAN;   Toronto Blue Jays shortstop Bo Bichette (11) hits a solo home run against the Arizona Diamondbacks in the ninth inning at Rogers Centre. Mandatory Credit: Dan Hamilton-Imagn Images

Toronto Blue Jays vs Chicago White Sox Prediction 06/22/2025 Picks

Pick details

Chicago (24-53) vs Toronto (41-35)

June 22, 2025 at 01:37 PM EDT

The Line: Betting Odds: Toronto -200 — Over/Under: +9

(Get latest betting odds)

The Chicago White Sox and the Toronto Blue Jays meet Sunday in MLB action from Rogers Centre. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Chicago White Sox vs. Toronto Blue Jays prediction.

Starting Pitching Matchup

The Chicago White Sox will send out Adrian Houser for the start here and Houser said 2-2 with a 2.15 ERA and 22 strikeouts this season. In his career, Houser is 0-2 with a 9.58 ERA and 6 strikeouts against Toronto. Chris Bassitt will get the start for the Blue Jays here and is 7-3 with a 3.75 ERA and 83 strikeouts this season. In his last five starts against the White Sox, Bassitt is 3-1 with a 2.84 ERA and 21 strikeouts.

Chicago White Sox Recap

The Chicago White Sox come into this game looking to bounce back from their 7-1 loss at the hands of the Blue Jays on Saturday to fall to 24-53 on the year. After this series, the White Sox will head home for a series against the Arizona Diamondbacks.

White Sox Get Right Back To Losing After Series-Opening Win

Lenyn Sosa has 59 hits including 12 doubles and 17 RBIs. Andrew Benintendi has 44 hits including 9 doubles, 8 home runs, 29 RBIs and a .250 batting average while Miguel Vargas has a team-high 64 hits, 19 doubles, 10 home runs and 32 RBIs. Brooks Baldwin has also added 16 RBIs while Luis Robert Jr. has a team-high 22 stolen bases along with 30 RBIs so far this season. Andrew Vaughn has 5 home runs and 19 RBIs as well as 8 doubles this season.

Why the Chicago White Sox will win

The Blue Jays have lost three of their last four games as favorites against AL Central opponents following a win.
The road team has won four of the White Sox’s last five games.
The White Sox have covered the run line in seven of their last eight games against American League opponents following a loss.
The Blue Jays have failed to cover the run line in six of their last seven day games against American League opponents following a home win.

Chicago White Sox Player Prop Facts

Miguel Vargas has hit a home run in four of the White Sox’s last five Sunday games.
Adrian Houser has recorded a win in three of his last four appearances in day games against AL teams that held a winning record.
Luis Robert has recorded at least one RBI in three of his last four appearances with the White Sox as road underdogs.
Miguel Vargas has scored at least one run in each of the White Sox’s last six road games.
Adrian Houser has recorded six strikeouts in each of his last three appearances in day games.
Mike Tauchman has recorded at least one hit in 10 of his last 11 road appearances.
Luis Robert ranks 4th in the league in Steals (22) this season.

Toronto Blue Jays Recap

The Toronto Blue Jays come into this game looking to add on to their win over the White Sox from Saturday’s matchup to improve to 41-35 on the year. After this series, the Blue Jays will head on the road for a series against the Cleveland Guardians.

Blue Jays Looking For Another Series Win

George Springer has 55 hits and Bo Bichette has 88 hits with Springer adding 10 home runs, a triple, 15 doubles and 32 RBIs while Bichette has 19 doubles, 10 home runs and 45 RBIs. Andres Gimenez has added 33 hits with 6 doubles and 4 home runs and 14 RBIs this season along with 9 stolen bases while Anthony Santander has 55 strikeouts so far this season. Vladimir Guerrero Jr. also has 9 homers, 16 doubles and 38 RBIs while Springer also has a .241 batting average and 61 strikeouts up to this point in the year. Daulton Varsho also has 8 home runs and 20 RBIs as well this season.

Why the Toronto Blue Jays will win

The White Sox have lost each of their last 11 games against American League opponents following a road loss.
The Blue Jays have won eight of their last nine games against the White Sox following a win.
The White Sox have failed to cover the run line in each of their last five day games against the Blue Jays following a loss.
The Blue Jays have covered the run line in five of their last six games against the White Sox.

Toronto Blue Jays Player Prop Facts

Bo Bichette has hit a home run in each of his last two appearances in day games against AL Central teams that held a losing record.
Bo Bichette has recorded at least one RBI in each of the Blue Jays’ last six games as favorites against the White Sox.
Chris Bassitt has recorded a win in each of his last four home appearances against the White Sox.
Vladimir Guerrero Jr. has scored at least one run in 12 of the Blue Jays’ last 13 games as favorites against AL opponents.
Chris Bassitt has recorded six strikeouts in each of his last three appearances with the Blue Jays as favorites against AL opponents.
Daulton Varsho has recorded a Double in four of his last five appearances in day games.
Daulton Varsho has recorded at least one hit in each of his last 11 home appearances against opponents that held a losing record.
Bo Bichette ranks T5th in the league in Hits (89) this season.

Total Runs Facts

Each of the White Sox’s last six games against AL East opponents have gone UNDER the total runs line.
Each of the Blue Jays’ last four home games against AL Central opponents have gone UNDER the total runs line.

Chicago White Sox vs. Toronto Blue Jays Prediction

I’m on the Blue Jays in this one. There’s been a couple of spots where Houser this season has been able to provide some value but the Blue Jays have been so solid against right-handed pitching in recent weeks that I think Houser gets chased here and I don’t think that the White Sox’s offense is good enough to get to Bassitt for very much here. Give me Toronto in this one for another series W.

Chris Ruffolo's Pick: Toronto -200

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