Sep 13, 2025; Chicago, Illinois, USA; Fans hold up signs for former Chicago Cubs player Anthony Rizzo during a game against the Tampa Bay Rays at Wrigley Field. Mandatory Credit: Patrick Gorski-Imagn Images

Tampa Bay Rays vs Chicago Cubs Prediction 9/14/2025 Today’s MLB Picks

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Tampa Bay (73-75) vs Chicago (84-64)

September 14, 2025 at 02:20 PM EDT

The Line: Betting Odds: Chicago -1.5 — Over/Under: +7.5

(Get latest betting odds)

The Tampa Bay Rays and Chicago Cubs meet Sunday in MLB action at Wrigley Field. Here’s a Tampa Bay Rays vs Chicago Cubs Prediction. This article will include a Tampa Bay Rays vs Chicago Cubs Pick.

Tampa Bay Rays Betting Preview

The Tampa Bay Rays are 73-75 on the year and play the Blue Jays, Red Sox, and Orioles next. The Tampa Bay Rays are batting .252 on the season, have a .313 OBP, and a .404 slugging percentage. The Tampa Bay Rays pitching staff has a 3.90 ERA and a 1.21 WHIP. Yandy Diaz leads the Tampa Bay Rays with 159 hits and 78 RBI, while Junior Caminero and Brandon Lowe have combined for 267 hits and 182 RBI.

Adrian Houser gets the ball for the Tampa Bay Rays, and he is 8-4 with a 3.11 ERA and 83 strikeouts this season. Houser is 4-2 with a 3.98 ERA and 52 strikeouts in his career against the Chicago Cubs.

Chicago Cubs Betting Preview

The Chicago Cubs are 84-64 on the year and play the Pirates, Reds, and Mets next. The Chicago Cubs are batting .248 on the season, have a .320 OBP, and a .426 slugging percentage. The Chicago Cubs pitching staff has a 3.87 ERA and a 1.19 WHIP. Nico Hoerner leads the Chicago Cubs with 160 hits and 56 RBI while Pete Crow-Armstrong and Dansby Swanson have combined for 267 hits and 161 RBI.

Shota Imanaga gets the ball for the Chicago Cubs, and he is 9-7 with a 3.21 ERA and 101 strikeouts this season. This will be Imanaga’s first career game against the Tampa Bay Rays.

Tampa Bay Rays @ the Chicago Cubs Betting Trends: September 14, 2025

  • Probable Starting Pitcher: Shota Imanaga      Record this season: 9-7      ERA: 3.21
  • Home Record: 4-2
  • Last 5 against Rays: –

Why the Chicago Cubs will win

  • The Cubs have won seven of their last eight day games against AL East opponents following a loss.
  • The Rays have lost each of their last seven games as underdogs against NL Central opponents following a road win.
  • The Rays have failed to cover the run line in each of their last seven games after playing the previous day.
  • The Cubs have covered the run line in eight of their last nine day games against AL East opponents following a home loss.
  • The Rays have trailed after 3 innings in each of their last four games.
  • The Cubs have led after 5 innings in eight of their last nine home games against AL East opponents.
  • Probable Starting Pitcher: Adrian Houser      Record this season: 8-4      ERA: 3.11
  • Road Record: 1-4
  • Last 5 against Cubs: 2-0

Why the Tampa Bay Rays will win

  • The Cubs have lost each of their last three games as home favorites after playing the previous day.
  • The Rays have won six of their last seven games as road underdogs against National League opponents following a road win.
  • The Cubs have failed to cover the run line in eight of their last nine games as favorites after playing the previous day.
  • The Rays have covered the run line in seven of their last eight games as road underdogs against National League opponents following a road win.

Total Runs Facts

  • Each of the Rays’ last four games as underdogs have gone OVER the total runs line.
  • Four of the Cubs’ last five home games have gone OVER the total runs line.
  • The ‘Inning 1 OVER 0.5 runs’ market has hit in four of the Rays’ last five games.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in four of the last five games between the Rays and Cubs.

Chicago Cubs Player Prop Facts

  • Ian Happ has hit a home run in four of the Cubs’ last seven day games against opponents that held a losing record.
  • Shota Imanaga has recorded a win in five of his last six appearances at Wrigley Field against opponents that held a losing record.
  • Dansby Swanson has recorded a Double in five of the Cubs’ last six games against AL opponents.
  • Nico Hoerner has recorded at least one hit in each of the Cubs’ last eight games.
  • Shota Imanaga has recorded five or more strikeouts in each of his last five appearances in day games.

Tampa Bay Rays Player Prop Facts

  • Brandon Lowe has recorded at least one hit in each of his 10 previous Sunday day appearances against NL teams that held a winning record.
  • Adrian Houser has recorded four or more strikeouts in each of his last five road appearances against NL opponents.
  • Brandon Lowe has hit a home run in three of his last six appearances against NL opponents.
  • Taylor Walls has recorded a Double in three of his last four road appearances against opponents that held a winning record.

Tampa Bay Rays vs Chicago Cubs Prediction

Houser has been solid this season and the Rays have won his last 5 starts. I still don’t like how the Rays are playing this week overall. Imanaga remains one of the better pitchers in the NL and has allowed 3 or fewer earned runs in 8 straight starts. In 60.2 home innings, Imanaga has a 3.12 ERA and .189 allowed batting average. Quick turnaround, give me the Cubs at home with their ace on the bump.

Randy Chambers's Pick: Chicago Cubs

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