Jun 30, 2025; Pittsburgh, Pennsylvania, USA;  St. Louis Cardinals left fielder Jose Fermin (15) hits a single against the Pittsburgh Pirates during the ninth inning at PNC Park. Mandatory Credit: Charles LeClaire-Imagn Images

St. Louis Cardinals vs Pittsburgh Pirates Prediction 07/01/2025 Picks

Pick details

St. Louis (47-39) vs Pittsburgh (36-50)

July 1, 2025 at 06:40 PM EDT

The Line: Betting Odds: Pittsburgh -1.5 — Over/Under: +7.5

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The St. Louis Cardinals and Pittsburgh Pirates meet Tuesday in MLB action at PNC Park. Here’s a St. Louis Cardinals vs Pittsburgh Pirates Prediction. This article will include a St. Louis Cardinals vs Pittsburgh Pirates Pick.

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 47-39 on the year and play the Cubs, Nationals, and Braves next. The St. Louis Cardinals are batting .254 on the season, have a .324 OBP, and a .396 slugging percentage. The St. Louis Cardinals pitching staff has a 3.95 ERA and a 1.26 WHIP. Brendan Donovan leads the St. Louis Cardinals with 89 hits and 31 RBI, while Willson Contreras and Nolan Arenado have combined for 150 hits and 92 RBI. 

Andre Pallante gets the ball for the St. Louis Cardinals, and he is 5-4 with a 4.43 ERA and 60 strikeouts this season. Pallante is 1-1 with a 2.65 ERA and 22 strikeouts in his career against the Pittsburgh Pirates.

Pittsburgh Pirates Betting Preview

The Pittsburgh Pirates are 36-50 on the year and play the Mariners, Royals, and Twins next. The Pittsburgh Pirates are batting .235 on the season, have a .308 OBP, and a .349 slugging percentage. The Pittsburgh Pirates pitching staff has a 3.73 ERA and a 1.20 WHIP. Bryan Reynolds leads the Pittsburgh Pirates with 76 hits and 45 RBI while Ke’Bryan Hayes and Andrew McCutchen have combined for 142 hits and 60 RBI.

Paul Skenes gets the ball for the Pittsburgh Pirates, and he is 4-7 with a 2.12 ERA and 110 strikeouts this season. Skenes is 0-4 with a 2.76 ERA and 36 strikeouts in his career against the St. Louis Cardinals.

Why the Pittsburgh Pirates will win

The Pirates have won each of their last eight games at PNC Park against National League opponents that held a winning record.
The Cardinals have lost five of their last six road games against NL Central opponents.
The Pirates have covered the run line in eight of their last nine night games against National League opponents that held a winning record.
The Cardinals have failed to cover the run line in four of their last five games at PNC Park against teams that held a losing record.
The Cardinals have trailed after 3 innings in each of their last four games as underdogs against National League opponents.
The Cardinals have trailed after 5 innings in eight of their last 10 road games against NL Central opponents that held a losing record.

Why the St. Louis Cardinals will win

The Cardinals have won six of their last seven games as road underdogs against the Pirates following a road loss.
The Pirates have lost four of their last five games as favorites against the Cardinals following a win.
The Cardinals have covered the run line in each of their last six road games against National League opponents following a road loss.
The Pirates have failed to cover the run line in six of their last seven games as home favorites against NL Central opponents.

Pittsburgh Pirates Player Prop Facts

Bryan Reynolds has recorded a Double in four of the Pirates’ last five games at PNC Park.
Ke’Bryan Hayes has recorded at least one hit in each of his last 10 home appearances.
Jack Suwinski has hit a home run in three of his last four Tuesday appearances against NL teams that held a winning record.
Paul Skenes ranks 4th amongst qualified players for Earned Run Average (2.12) this season.

St. Louis Cardinals Player Prop Facts

Lars Nootbaar has hit a home run in each of his last two appearances with the Cardinals as underdogs against NL Central opponents.
Brendan Donovan has recorded at least one hit in 12 of his last 13 appearances in night games against teams that held a losing record.

St. Louis Cardinals vs Pittsburgh Pirates Prediction

I considered the Cardinals because they’re playing great ball over the last month, and it doesn’t matter how good Skenes is when he sometimes doesn’t get run support. However, the Pirates are on a mini winning stretch, and you’d think that would continue at home with one of the best pitchers in baseball. Skenes is a legit CY Young candidate with his 2.12 ERA and 0.91 WHIP. In 45.2 home innings, Skenes has 42 strikeouts and is allowing a .179 batting average. Pallante has been good in his last two starts, but he’s hittable with a 4.43 ERA and 1.35 WHIP, and his ERA jumps up to 4.60 on the road. I’ll roll with the Pirates and their ace on Tuesday night.

Randy Chambers's Pick: Pittsburgh Pirates

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