St. Louis Cardinals vs Milwaukee Brewers Prediction 9/25/2026 Today’s MLB Picks

The St. Louis Cardinals and the Milwaukee Brewers meet Friday in MLB action from American Family Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a St. Louis Cardinals vs. Milwaukee Brewers prediction.

Starting Pitching Matchup

The St. Louis Cardinals will send out Michael McGreevy here and McGreevy is 7-9 with a 3.84 ERA and 113 strikeouts this season. Robert Gasser will start for Milwaukee and is 5-5 with a 4.01 ERA and 94 strikeouts this season.

St. Louis Cardinals Recap

The St. Louis Cardinals come into this game looking to bounce back from a 2-1 loss at the hands of the Pirates last time out to sit at 77-82 this season. 

Cardinals Alternate Wins & Losses In 5 Straight

Alec Burleson leads the Cardinals across the board with a team-high 167 hits and 113 RBIs while adding 37 doubles, a triple, and 24 home runs so far this season. Jordan Walker paces St. Louis with a team-high 28 home runs while contributing 162 hits, 33 doubles, and 100 RBIs on the year. Iván Herrera has added 145 hits with 26 doubles, a triple, 18 home runs, and 68 RBIs, while JJ Wetherholt has logged 130 hits with 15 doubles, 17 home runs, and 51 RBIs. Masyn Winn has recorded 109 hits with 21 doubles, 2 triples, 5 home runs, and 56 RBIs, and Nathan Church has chipped in 107 hits with 17 doubles, 2 triples, 10 home runs, and 50 RBIs for St. Louis up to this point in the season.

Milwaukee Brewers Recap

The Milwaukee Brewers come into this game looking to add on to their 5-1 win over Philadelphia last time out to sit at 100-59 this season.

Brewers Reach 100 Wins For First Time In Franchise History

Brice Turang and William Contreras tie for the Brewers’ team lead with 151 hits each, with Turang pacing Milwaukee in RBIs with 94 alongside 35 doubles, 3 triples, and 20 home runs, while Contreras has added 27 doubles, a triple, 18 home runs, and 93 RBIs so far this season. Jackson Chourio has contributed 146 hits with 27 doubles, 25 home runs, and 71 RBIs on the year. Jake Bauers leads Milwaukee with a team-high 26 home runs while adding 125 hits, 22 doubles, 2 triples, and 84 RBIs. Garrett Mitchell has logged 119 hits with 30 doubles, 4 triples, 11 home runs, and 65 RBIs, while Sal Frelick has chipped in 78 hits with 18 doubles, 4 home runs, and 40 RBIs for the Brewers up to this point in the season.

St. Louis Cardinals @ Milwaukee Brewers Betting Trends: September 25, 2026

• Probable Starting Pitcher: Robert Gasser      Record this season: 5-5      ERA: 4.01
• Home Record: 1-2
• Last 5 against Cardinals: 2-1

Why the Milwaukee Brewers will win

• The Brewers have won each of their last eight night games after playing the previous day.
• The Cardinals have lost eight of their last nine night games at American Family Field following a loss.
• The Brewers have covered the run line in each of their last six home games following a road win.
• The Cardinals have failed to cover the run line in six of their last seven night games against NL opponents.
• The Brewers have won the first inning in six of their last seven home games against opponents that held a losing record.
• The Brewers have led after 3 innings in seven of their last eight games as favorites against NL opponents.
• The Brewers have led after 5 innings in seven of their last eight home games against NL opponents that held a losing record.

• Probable Starting Pitcher: Michael McGreevy      Record this season: 7-9      ERA: 3.84
• Road Record: 4-5
• Last 5 against Brewers: 1-1

Why the St. Louis Cardinals will win

• The Brewers have lost three of their last four games as favorites against NL Central opponents following a road win.
• The Cardinals have won three of their last four games as underdogs against NL Central opponents following a road loss.
• The Brewers have failed to cover the run line in 12 of their last 13 games as favorites against the Cardinals following a win.
• The Cardinals have covered the run line in 11 of their last 12 games as underdogs after playing the previous day.
• The Cardinals have led after 3 innings in four of their last five night games against opponents that held a winning record.
• The Cardinals have led after 5 innings in five of their last six night games against NL Central opponents.

Total Runs Facts

• Each of the Cardinals’ last four games have gone UNDER the total runs line.
• Each of the last four games between the Cardinals and Brewers at American Family Field have gone UNDER the total runs line.
• There has been at least one run scored in the first inning in each of the Brewers’ last 10 night games at American Family Field.
• There has been at least one run scored in the first inning in seven of Michael McGreevy’s last eight road appearances as a starter.

Milwaukee Brewers Player Prop Facts

• William Contreras has hit a home run in each of his last three home appearances.
• Joey Ortiz has recorded at least one hit in each of his last 10 appearances against NL opponents.
• Jake Bauers ranks 2nd amongst qualified players for On Base Percentage (.393) this season.

St. Louis Cardinals Player Prop Facts

• Alec Burleson has hit a home run in three of the Cardinals’ last five games against NL Central opponents that held a winning record.
• Michael McGreevy has recorded a win in each of his last three appearances against opponents that held a winning record.
• Michael McGreevy has recorded four or more strikeouts in each of his last six road appearances.
• JJ Wetherholt has recorded two or more hits in each of his last four road appearances after playing the previous day.
• Alec Burleson ranks T9th in the league in Hits (167) this season.

Matchup/League Facts

• The Brewers rank 1st in the league for hits this season (1392).
• The Brewers rank 1st in the league for on-base percentage this season (.340).
• The Cardinals rank 27th in the league for slugging percentage this season (.379).
• The Cardinals rank 4th in the league for home runs allowed this season (156).

St. Louis Cardinals vs. Milwaukee Brewers Prediction

I’m on the Brewers here. I’m still not the biggest fan of Robert Gasser as I don’t see him in this Brewers rotation consistently come playoff time and probably out of the bullpen more often than not. That being said, Milwaukee is playing the far better baseball and haven’t let clinching the division and hitting 100 wins slow them down. St. Louis just looks done and I think the Brewers pick up another win in this one. Give me Milwaukee.

Chris Ruffolo's Pick: Milwaukee -185