St. Louis Cardinals vs Milwaukee Brewers Prediction 5/27/2026 Today’s MLB Picks

In this article, we will formulate a Cardinals vs Brewers Prediction for this MLB matchup on Wednesday, May 27th in the third game of this series. Let’s take a look at the prediction for this MLB matchup.

Milwaukee Brewers Preview

The Milwaukee Brewers have a 32-20 record this season and are sitting in the first place of the NL Central. They have a 18-11 home record and are coming off a 6-0 home win against the Cardinals. They will face the Astros and the Giants next.

The Brewers have a .249 batting average this season, .335 OBP and .368 Slugging percentage. Milwaukee’s pitching staff has a 3.19 ERA and 1.19 WHIP. William Contreras is the team’s best hitter with a .308 batting average, also leading the team in RBI with 33. Jake Bauers adds a team-high 8 home runs.

The Brewers have not yet announced a starting pitcher for this game.

St. Louis Cardinals Preview

The St. Louis Cardinals have a 29-24 record this season and are sitting in the second place of the NL Central. They have a 16-11 away record and are coming off a 0-6 road defeat against the Brewers. They will face the Cubs and the Rangers next.

The Cardinals have a .238 batting average this season, .318 OBP and .384 Slugging percentage. St. Louis’ pitching staff has a 4.27 ERA and 1.39 WHIP. Jordan Walker is the team’s best hitter with a .296 batting average, also leading the team in RBI with 42 and adding a team-high 15 home runs.

Dustin May (R) is the projected starting pitcher for the Cardinals, and he has a 3-5 record, 5.00 ERA and 1.43 WHIP.

St. Louis Cardinals @ Milwaukee Brewers Betting Trends: May 27, 2026

• Probable Starting Pitcher: TBD

Why the Milwaukee Brewers will win

• The Brewers have won each of their last six games against NL Central opponents.
• The Cardinals have lost seven of their last eight games against NL Central opponents following a road loss.
• The Brewers have covered the run line each of their last seven day games against NL Central opponents that held a winning record.
• The Cardinals have failed to cover the run line in each of their last five games against NL Central opponents following a road loss.
• The Brewers have led after 3 innings in eight of their last nine games against opponents that held a winning record.
• The Brewers have won the first inning in four of their last five games as favorites against National League opponents.
• The Brewers have led after 5 innings in each of their last eight games as home favorites.

• Probable Starting Pitcher: Dustin May      Record this season: 3-5      ERA: 5.00
• Road Record: 1-2
• Last 5 against Brewers: 0-0

Why the St. Louis Cardinals will win

• The Brewers have lost three of their last four games as favorites against the Cardinals following a win.
• The Cardinals have won eight of their last 11 games as road underdogs following a loss.
• The Brewers have failed to cover the run line in eight of their last nine games against the Cardinals following a win.
• The Cardinals have covered the run line in each of their last seven Wednesday games as road underdogs against NL Central opponents.

Total Runs Facts

• Each of the Cardinals’ last seven road games after playing the previous day have gone UNDER the total runs line.
• Each of the Brewers’ last four games as favorites have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in six of the Cardinals’ last seven road games against National League opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in five of the Brewers’ last six day games.

Milwaukee Brewers Player Prop Facts

• Christian Yelich has hit a home run in each of his last two appearances in day games.
• Sal Frelick has recorded at least one hit in each of his last eight appearances against the Cardinals.
• Brice Turang ranks 4th amongst qualified players for On Base Percentage (.407) this season.

St. Louis Cardinals Player Prop Facts

• Nolan Gorman has hit at least one home run in three of his last 13 road appearances against the Brewers after playing the previous day.
• Dustin May has recorded six or more strikeouts in each of his three previous appearances in day games against NL Central teams that held a winning record.
• Ramon Urias has recorded at least one hit in each of his last seven appearances against the Brewers.
• Jordan Walker ranks 4th amongst qualified players for Slugging Percentage (.578) this season.

Matchup/League Facts

• The Brewers rank 30th in the league for home runs this season (37).
• The Brewers rank 1st in the league for home runs allowed this season (37).
• The Cardinals rank 29th in the league for strikeouts this season (404).
• The Cardinals rank T28th in the league for triples this season (3).

Cardinals vs Brewers Prediction

The Brewers have won their last three meetings against the Cardinals and are 4-1 in their last 5 meetings in Milwaukee.  

In this Cardinals vs Brewers Prediction, the Brewers are coming as -150 home favorites. Even without a pitcher announced, you just have to ride with the Brewers in this one. They have dominated both games in this series with a combined 11-1 score and Dustin May has been terrible for the Cardinals and even weaker on the road. The Brewers have both a better offense and a better bullpen and I expect them to keep rolling and sweep the Cardinals in this series.

Nikos Lagouretos's Pick: Milwaukee Brewers ML