The St. Louis Cardinals and Chicago White Sox meet Wednesday in MLB action at Rate Field. Here’s a St. Louis Cardinals vs Chicago White Sox Prediction. This article will include a St. Louis Cardinals vs Chicago White Sox Pick.

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 38-35 on the year and play the Reds, Cubs, and Guardians next. The St. Louis Cardinals are batting .257 on the season, have a .328 OBP, and a .393 slugging percentage. The St. Louis Cardinals pitching staff has a 3.97 ERA and a 1.27 WHIP. Brendan Donovan leads the St. Louis Cardinals with 83 hits and 27 RBI, while Willson Contreras and Nolan Arenado have combined for 127 hits and 81 RBI. 

Sonny Gray gets the ball for the St. Louis Cardinals, and he is 7-2 with a 3.84 ERA and 85 strikeouts this season. Gray is 7-2 with a 3.26 ERA and 69 strikeouts in his career against the Chicago White Sox.

Chicago White Sox Betting Preview

The Chicago White Sox are 23-50 on the year and play the Blue Jays, Diamondbacks, and Giants next. The Chicago White Sox are batting .222 on the season, have a .293 OBP, and a .342 slugging percentage. The Chicago White Sox pitching staff has a 4.23 ERA and a 1.41 WHIP. Miguel Vargas leads the Chicago White Sox with 62 hits and 31 RBI, while Lenyn Sosa and Chase Meidroth have combined for 106 hits and 26 RBI.

Sean Burke gets the ball for the Chicago White Sox, and he is 3-7 with a 4.71 ERA and 54 strikeouts this season. This will be Burke’s first career game against the St. Louis Cardinals.

Why the Chicago White Sox will win

The White Sox have won eight of their last nine games as underdogs following a home loss.
The Cardinals have lost each of their last four games as favorites against American League opponents following a road win.
The White Sox have covered the run line in each of their last nine games as underdogs following a home loss.
The Cardinals have failed to cover the run line in each of their last six games as favorites against American League opponents following a win.
The White Sox have won the first inning in three of their last four games against NL Central opponents.

Why the St. Louis Cardinals will win

The White Sox have lost each of their last 11 night games against NL Central opponents following a loss.
The Cardinals have won seven of their last eight night games against teams that held a losing record.
The road team has covered the run line in eight of the Cardinals’ last nine games.
The White Sox have failed to cover the run line in each of their last six night games against National League opponents following a home loss.
The Cardinals have led after 3 innings in four of their last five games at Rate Field.
The White Sox have trailed after 5 innings in each of their last four night games.

Chicago White Sox Player Prop Facts

Miguel Vargas has hit a home run in three of his last five home appearances against NL Central opponents that held a winning record.
Miguel Vargas has recorded at least one hit in each of the White Sox’s last six games as underdogs.
Miguel Vargas has scored at least one run in each of the White Sox’s last five games as underdogs.
Miguel Vargas has recorded a Double in each of the White Sox’s last four games as underdogs against NL opponents.
Miguel Vargas has recorded at least one RBI in four of the White Sox’s last five games against NL Central opponents.

St. Louis Cardinals Player Prop Facts

Alec Burleson has hit a home run in each of the Cardinals’ last two games as road favorites against AL Central opponents.
Sonny Gray has recorded six or more strikeouts in each of his eight previous appearances with the Cardinals as favorites against AL opponents.
Alec Burleson has recorded at least one hit in each of the Cardinals’ last seven road games.
Sonny Gray has recorded a win in each of his last five appearances against AL opponents that held a losing record.
Masyn Winn has scored at least one run in each of the Cardinals’ last five games against AL opponents.
Willson Contreras has recorded a Double in three of the Cardinals’ last four games against AL Central opponents.
Willson Contreras has recorded at least one RBI in six of the Cardinals’ last seven games as favorites against AL opponents.
Sonny Gray ranks T6th in the league for Wins (7) this season.

St. Louis Cardinals vs Chicago White Sox Prediction

I’ve given the White Sox a chance in their last few games, and they’ve let me down. So, back to fading the White Sox the way I have over the last few years. The White Sox can’t string together offense, and they’ve lost six straight games. Gray is still out there dealing at 35 years old, as he has a 3.84 ERA and 1.18 WHIP. Yes, Gray has had issues on the road with a 5.88 RA and .284 allowed batting average, but that’s not an issue here against the White Sox. The White Sox suck. Give me the Cardinals with their all-star pitcher on the hill.

Randy Chambers's Pick: St. Louis Cardinals