May 4, 2025; Milwaukee, Wisconsin, USA; Chicago Cubs pitcher Shota Imanaga (18) delivers a pitch against the Milwaukee Brewers in the first inning at American Family Field. Mandatory Credit: Michael McLoone-Imagn Images

St. Louis Cardinals vs Chicago Cubs Prediction 06/26/2025 Picks

Pick details

Chicago (47-33) vs St. Louis (44-37)

June 26, 2025 at 02:15 PM EDT

The Line: Betting Odds: St. Louis +120 / Chicago -140 — Over/Under: +9

(Get latest betting odds)

The Chicago Cubs are visiting the Saint Louis Cardinals on Thursday, June 26th at the Busch Stadium in the fourth game of this series, with the Cardinals having the 2-1 lead. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Chicago Cubs vs Saint Louis Cardinals Prediction. We will examine:
The Saint Louis Cardinals recent form and player performance
The Chicago Cubs recent form and player performance
Recent betting trends and streaks involving the Saint Louis Cardinals
Recent betting trends and streaks involving the Chicago Cubs
Recent betting trends in games played between the Chicago Cubs vs Saint Louis Cardinals
A summary that ties it all together and produces a favorable betting outcome for the Chicago Cubs vs Saint Louis Cardinals game

Saint Louis Cardinals Preview

The Saint Louis Cardinals have a 44-37 record this season and are sitting on the third place of the NL Central. The Cardinals have a 26-16 home record and are 43-35 in over/under They are coming off a 0-8 home defeat by the Cubs, but are 8-2 in their last 10 games. They are playing the Guardians and the Pirates next.

The Cardinals have a .255 batting average this season, .325 OBP and .396 Slugging percentage. Saint Louis’ pitching staff has a 3.99 ERA and 1.27 WHIP. Brendan Donovan leads the Cardinals with 87 hits and is the team’s best hitter with a .305 batting average. Wilson Contreras leads the team in RBI, with 50, while Lars Nootbaar adds a team-high 11 home runs.

Andre Pallante (R) is the projected starting pitcher for the Cardinals, and he has a 5-3 record, 4.48 ERA and 1.31 WHIP.

Chicago Cubs Preview

The Chicago Cubs have a 47-33 record this season and are sitting on the first place of the NL Central. The Cubs have a 22-18 road record and are 40-32 in over/under. They are coming off an 8-0 road victory over the Cardinals, which snapped their previous three-game losing streak. Over is 6-1 in their last 7 games, and are playing the Astros and the Guardians next.

The Cubs have a .255 batting average this season, .325 OBP and .445 Slugging percentage. Chicago’s pitching staff has a 3.90 ERA and 1.26 WHIP. Nico Hoerner leads the Cubs with 86 hits and he is the team’s best hitter with a .294 batting average. Seiya Suzuki leads the team in RBI, with 67, adding a team-high 21 home runs.

Shota Imanaga (L) is the projected starting pitcher for the Cubs, and he has a 3-2 record, 2.82 ERA and 1.10 WHIP.

Why the St. Louis Cardinals will win

The Cardinals have won each of their last eight games as home underdogs following a home loss.
The Cubs have lost four of their last five games as favorites against the Cardinals following a win.
The Cardinals have covered the run line in each of their last eight games as home underdogs following a home loss.
The Cubs have failed to cover the run line in each of their last six day games following a win.
The Cubs have trailed after 3 innings in each of their last four day games against National League opponents that held a winning record.
The Cubs have trailed after 5 innings in each of their last four day games against National League opponents that held a winning record.

Why the Chicago Cubs will win

The Cubs have won 10 of their last 11 Thursday games.
The Cardinals have lost eight of their last nine Thursday games against NL Central opponents that held a winning record.
The Cardinals have failed to cover the run line in nine of their last 10 Thursday games against NL Central opponents that held a winning record.
The Cubs have covered the run line in each of their last five Thursday road games.
The Cubs have led after 3 innings in four of their last five games as favorites.
The Cubs have led after 5 innings in each of their last six Thursday road games.
The Cubs have won the first inning in three of their last four day games against opponents that held a winning record.

Total Runs Facts

Six of the Cubs’ last seven games have gone OVER the total runs line.
Five of the last six games between the Cubs and Cardinals at Busch Stadium have gone OVER the total runs line.
The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Cubs’ last six day games.
The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Cardinals’ last three day games at Busch Stadium.

Matchup/League Facts

The Cardinals rank T28th in the league for triples this season (4).
The Cardinals rank 28th in the league for strikeouts this season (587).
The Cubs rank 2nd in the league for runs scored this season (434).
The Cubs rank 2nd in the league for hits this season (708).

Chicago Cubs vs Saint Louis Cardinals Prediction

The Cubsare 5-3 in their last 8 overall meetings against the Cardinals, but the Cardinals are 4-2 in their last 6 meetings in Saint Louis. Over is 7-2 in their last 9 meetings.

In this Chicago CubsvsSaint Louis CardinalsPrediction, the Cubs are coming as -140 road favorites. The Cubs have a slightly better overall record, but Saint Louis has been strong at home, with 26 wins. The Cubs have the pitching advantage, with Imanaga on the mound, the better bullpen, and a better offense. The Cubs and are slightly better against righties, while the Cardinals are significantly weaker against lefties. Take the Chicago Cubs to win on the road.

Nikos Lagouretos's Pick: Chicago Cubs -140

Need More? Get Premium Picks

Hot Cappers this week

Latest Picks & Game Previews

  • Carlos Alcaraz vs Taylor Fritz Prediction 07/11/2025 Wimbledon Picks

    July 11, 2025

  • Jannik Sinner vs Novak Djokovic Prediction 07/11/2025 Wimbledon Picks

    July 11, 2025

  • MLB Player Prop Picks 07/11/2025 Picks (American League Pitchers)

    July 11, 2025

  • MLB Player Prop Picks 07/11/2025 Picks (National League Pitchers)

    July 11, 2025

  • Iga Swiatek vs Amanda Anisimova Prediction 07/12/2025 Wimbledon Picks

    July 12, 2025