Apr 24, 2026; St. Louis, Missouri, USA; Seattle Mariners center fielder Julio Rodríguez (44) catches a fly ball against the St. Louis Cardinals during the seventh inning at Busch Stadium. Mandatory Credit: Jeff Curry-Imagn Images
Jeff Curry-Imagn Images

Seattle Mariners vs St. Louis Cardinals Prediction 4/25/2026 Today’s MLB Picks

Pick details

MATCHUP Seattle Mariners St. Louis Cardinals
Team Records 12-15 14-11
Spread -1.5 113 +1.5 -136
Moneyline -149 +123
Total Over 7.5 (-110) Under 7.5 (-110)
Where Busch Stadium, St. Louis, Missouri
When Saturday, April 25, 2026
Time 02:15 PM EDT
TV MLB.TV

The Seattle Mariners and St. Louis Cardinals meet Saturday in MLB action at Busch Stadium. Here’s a Seattle Mariners vs. St. Louis Cardinals Prediction. This article will include a Seattle Mariners vs. St. Louis Cardinals Pick.

Seattle Mariners Betting Preview


The Seattle Mariners are 12-15 on the year and play the Royals and Twins next. The Seattle Mariners are batting. 223 on the season, have a .319 OBP, and have a .360 slugging percentage. The Seattle Mariners pitching staff has a 3.37 ERA and a 1.21 WHIP. Randy Arozarena leads the Seattle Mariners with 28 hits and 10 RBI while Cole Young and Julio Rodriguez have combined for 46 hits and 20 RBI.

Bryan Woo gets the ball for the Seattle Mariners, and he is 1-2 with a 2.25 ERA and 26 strikeouts this season. This will be Woo’s second career game against the St. Louis Cardinals.

St. Louis Cardinals Betting Preview


The St. Louis Cardinals are 14-11 on the year and play the Pirates and Dodgers next. The St. Louis Cardinals are batting .230 on the season and have a .319 OBP, and a .371 slugging percentage. The St. Louis Cardinals pitching staff has a 4.70 ERA and a 1.41 WHIP. Jordan Walker leads the St. Louis Cardinals with 26 hits and 16 RBI while Alec Burleson and Ivan Herrera have combined for 46 hits and 29 RBI.

Matthew Liberatore gets the ball for the St. Louis Cardinals, and he is 0-1 with a 3.67 ERA and 16 strikeouts this season. Liberatore is 0-1 with a 13.50 ERA and 1 strikeout in his career against the Seattle Mariners.

Why the St. Louis Cardinals will win

  • The Mariners have lost each of their last nine road games after playing the previous day.
  • The Cardinals have won each of their last four games as home underdogs against AL West opponents following a home loss.
  • The Mariners have failed to cover the run line in each of their last seven games as road favorites after playing the previous day.
  • The Cardinals have covered the run line each of their last six games against AL West opponents that held a losing record.
  • The Mariners have trailed after 5 innings in four of their last five day games against National League opponents that held a winning record.

Why the Seattle Mariners will win

  • The Mariners have won each of their last five day games after playing the previous day.
  • The Cardinals have lost five of their last six day games following a loss.
  • The Cardinals have failed to cover the run line in each of their last five day games against American League opponents following a home loss.
  • The Mariners have covered the run line in four of their last five games as favorites against the Cardinals.
  • The Cardinals have trailed after 3 innings in four of their last five day games against American League opponents that held a losing record.

Total Runs Facts

  • Each of the Mariners’ last five games as road favorites has gone UNDER the total runs line.
  • Each of the Cardinals’ last four games has gone UNDER the total runs line.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in eight of the Mariners’ last nine games at Busch Stadium.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Cardinals’ last four home games against AL West opponents.

St. Louis Cardinals Player Prop Facts

  • Masyn Winn has recorded at least one hit in each of his last eight appearances with the Cardinals as underdogs.
  • Ramon Urias has hit a home run in three of his last six home appearances against AL West opponents that held a losing record.
  • Jordan Walker ranks 9th amongst qualified players for Slugging Percentage (.581) this season.

Seattle Mariners Player Prop Facts

  • Cal Raleigh has hit at least one home run in four of the Mariners’ last five road games against NL Central opponents that held a winning record.
  • Randy Arozarena has recorded at least one hit in each of his last 10 appearances with his team as a favorite against the Cardinals.

Matchup/League Facts

  • The Cardinals rank 26th in the league for ERA this season (4.70).
  • The Cardinals rank T25th in the league for doubles this season (34).
  • The Mariners rank 28th in the league for strikeouts against this season (246).
  • The Mariners rank 4th in the league for ERA this season (3.37).

Seattle Mariners vs St. Louis Cardinals Prediction


The Mariners are going to be favored with the way Woo has pitched. We’re talking about a pitcher who has a 2.25 ERA and 0.88 WHIP through 32 innings. Liberatore has been far more hittable and has 10 walks in 27 innings. Still, the value is with the Cardinals at home and the more favorable price. The Mariners are just 2-8 on the road this season and these quick turnarounds and early start times usually favor the home team. Give me the Cardinals.

Randy Chambers's Pick: St. Louis Cardinals