San Francisco Giants vs Los Angeles Dodgers Prediction 9/21/2025 Today’s MLB Picks

The San Francisco Giants and the Los Angeles Dodgers meet Sunday in MLB action from Dodger Stadium. We will look at this from a betting perspective and determine the best bets for this game. Here’s a San Francisco Giants vs. Los Angeles Dodgers prediction.

Starting Pitching Matchup

The San Francisco Giants will start Trevor McDonald here and McDonald is 0-0 with a 9.00 ERA and 1 strikeout this season. This will be McDonald’s first career start against the Dodgers. Emmet Sheehan will start for Los Angeles here and is 6-3 with a 3.17 ERA and 76 strikeouts this season. In his career, Sheehan is 0-0 with a 0.84 ERA and 12 strikeouts against the Giants.

San Francisco Giants Recap

The San Francisco Giants come into this game looking to bounce back from their 7-5 loss at the hands of the Dodgers in Saturday’s matchup, falling to 76-79 this season. After this series, the Giants will square off against the St. Louis Cardinals in a series at home.

Giants Drop 8 Of Their Last 10

Jung Hoo Lee has 139 hits including a team-high 30 doubles along with 11 triples, 8 home runs and 52 RBIs with 10 stolen bases while Heliot Ramos has 149 hits with 24 doubles, 17 home runs and 61 RBIs. Wilmer Flores also 16 home runs and 70 RBIs while Tyler Fitzgerald has 9 stolen bases as well on the year. Matt Chapman also has 99 hits with 21 home runs and 58 RBIs along with 20 doubles and Willy Adames has 126 hits with 20 doubles, 28 home runs and 82 RBIs of his own this season. 

Los Angeles Dodgers Recap

The Los Angeles Dodgers come into this game looking to add on to their win over the Giants from Saturday’s clash to improve to 88-67 this season. After this series, the Dodgers will head on the road for an NL West division showdown against the Arizona Diamondbacks.

Dodgers’ Win Streak Hits Four

Shohei Ohtani has 162 hits including 22 doubles, 51 home runs, 95 RBIs and 8 triples. Michael Conforto has 78 hits with 20 doubles while Teoscar Hernandez has 119 hits with 24 home runs, 28 doubles and 84 RBIs as well this season. Ohtani has a team-high 19 stolen bases while Max Muncy has 10 doubles but also has 73 strikeouts so far this season. Mookie Betts has also chipped in 19 home runs and 78 RBIs as well on the year. Freddie Freeman has also logged 155 hits with a team-high 39 doubles, 21 home runs and 83 RBIs. Andy Pages also has 151 hits with 25 doubles, 25 home runs and 81 RBIs as well this season.

San Francisco Giants @ Los Angeles Dodgers Betting Trends: September 21, 2025

• Probable Starting Pitcher: Emmet Sheehan      Record this season: 6-3      ERA: 3.17
• Home Record: 3-1
• Last 5 against Giants: 1-0

Why the Los Angeles Dodgers will win

• The Dodgers have won each of their last 14 day games against NL West opponents.
• The Giants have lost eight of their last nine games after playing the previous day.
• The Dodgers have covered the run line each of their last six games against teams that held a losing record.
• The Giants have failed to cover the run line in four of their last five day games against NL West opponents that held a winning record.
• The Dodgers have led after 3 innings in seven of their last eight day games.
• The Dodgers have won the first inning in six of their last seven day games.
• The Dodgers have led after 5 innings in eight of their last nine day games against National League opponents.

• Probable Starting Pitcher: Trevor McDonald      Record this season: 0-0      ERA: 9.00
• Road Record: 0-0
• Last 5 against Dodgers: –

Why the San Francisco Giants will win

• The Dodgers have failed to cover the run line in each of their last five day games at Dodger Stadium following a win.
• The Giants have covered the run line in 13 of their last 14 Sunday games as road underdogs.
• The Dodgers have trailed after 3 innings in six of their last eight games against National League opponents that held a losing record.

Total Runs Facts

• Six of the Giants’ last seven day games against National League opponents have gone UNDER the total runs line.
• Three of the Dodgers’ last four day games against NL West opponents have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in six of the Dodgers’ last seven day games.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in five of the Giants’ last six games at Dodger Stadium.

Los Angeles Dodgers Player Prop Facts

• Mookie Betts has recorded a Double in three of the Dodgers’ last four games against opponents that held a losing record.
• Shohei Ohtani has hit a home run in four of the Dodgers’ last five games.
• Freddie Freeman has recorded at least one hit in each of his last nine appearances in day games against NL teams that held a losing record.
• Shohei Ohtani ranks T2nd in the league in Home Runs (53) this season.

San Francisco Giants Player Prop Facts

• Rafael Devers has hit a home run in four of the Giants’ last 10 road games against NL West opponents.
• Dominic Smith has recorded a Double in three of his last four road appearances against the Dodgers.
• Dominic Smith has recorded at least one hit in 17 of his last 19 road appearances.

Matchup/League Facts

• The Dodgers rank 2nd in the league for runs scored this season (793).
• The Dodgers rank 2nd in the league for home runs this season (232).
• The Giants rank 1st in the league for home runs allowed this season (136).
• The Giants rank 29th in the league for steals this season (66).

San Francisco Giants vs. Los Angeles Dodgers Prediction

I’m on the Dodgers in this game. The Giants just look like they’ve waved the white flag on the season, sending Trevor McDonald out, likely in an opener role, but San Francisco as a whole has just faded down the stretch after looking like a dark horse contender for a wild card spot early in the month. The Dodgers on the other hand have been solid and send out Sheehan who has been good in his own right as of late and has yet to allow a hit in two career starts against San Francisco. I’ll roll with the Dodgers here.