San Francisco Giants vs Los Angeles Dodgers Prediction 9/18/2025 Today’s MLB Picks

The San Francisco Giants and the Los Angeles Dodgers meet Thursday in MLB action from Dodger Stadium. We will look at this from a betting perspective and determine the best bets for this game. Here’s a San Francisco Giants vs. Los Angeles Dodgers prediction.

Starting Pitching Matchup

The San Francisco Giants will send out Logan Webb for the start here and Webb is 14-10 with a 3.34 ERA and 206 strikeouts his season. In his last five starts against the Dodgers, Webb is 2-1 with a 6.35 ERA and 25 strikeouts. Yoshinobu Yamamoto will start for the Dodgers here and is 11-8 with a 2.66 ERA and 187 strikeouts this season. In his career, Yamamoto is 0-1 with a 3.70 ERA and 27 strikeouts against the San Francisco Giants.

San Francisco Giants Recap

The San Francisco Giants come into this game looking to add on to their 5-1 win over the Arizona Diamondbacks last time out to sit at 76-76 this season. After this series, the Giants will head home for a series against the St. Louis Cardinals.

Giants Looking To Keep Playoff Hopes Alive

Jung Hoo Lee has 139 hits including a team-high 30 doubles along with 11 triples, 8 home runs and 52 RBIs with 10 stolen bases while Heliot Ramos has 149 hits with 24 doubles, 17 home runs and 61 RBIs. Wilmer Flores also 16 home runs and 70 RBIs while Tyler Fitzgerald has 9 stolen bases as well on the year. Matt Chapman also has 99 hits with 21 home runs and 58 RBIs along with 20 doubles and Willy Adames has 126 hits with 20 doubles, 28 home runs and 82 RBIs of his own this season. 

Los Angeles Dodgers Recap

The Los Angeles Dodgers come into this game looking to build on a 5-0 win over the Philadelphia Phillies last time out to sit at 85-67 this season. After this series, the Dodgers will head on the road for a series against the Arizona Diamondbacks.

Dodgers Snap Losing Skid

Shohei Ohtani has 162 hits including 22 doubles, 51 home runs, 95 RBIs and 8 triples. Michael Conforto has 78 hits with 20 doubles while Teoscar Hernandez has 119 hits with 24 home runs, 28 doubles and 84 RBIs as well this season. Ohtani has a team-high 19 stolen bases while Max Muncy has 10 doubles but also has 73 strikeouts so far this season. Mookie Betts has also chipped in 19 home runs and 78 RBIs as well on the year. Freddie Freeman has also logged 155 hits with a team-high 39 doubles, 21 home runs and 83 RBIs. Andy Pages also has 151 hits with 25 doubles, 25 home runs and 81 RBIs as well this season.

San Francisco Giants @ Los Angeles Dodgers Betting Trends: September 18, 2025

• Probable Starting Pitcher: Yoshinobu Yamamoto      Record this season: 11-8      ERA: 2.66
• Home Record: 3-4
• Last 5 against Giants: 0-1

Why the Los Angeles Dodgers will win

• The Giants have lost each of their last nine games against the Dodgers following a win.
• The Dodgers have won seven of their last eight home games against the Giants following a home win.
• The Giants have failed to cover the run line each of their last 10 Thursday games against teams that held a winning record.
• The Dodgers have covered the run line in five of their last six games against NL West opponents.
• The Dodgers have led after 3 innings in four of their last five home games.
• The Giants have lost the first inning in three of their last four night games at Dodger Stadium.
• The Dodgers have led after 5 innings in seven of their last eight games.

• Probable Starting Pitcher: Logan Webb      Record this season: 14-10      ERA: 3.34
• Road Record: 7-6
• Last 5 against Dodgers: 2-1

Why the San Francisco Giants will win

• The Giants have won each of their last four games as underdogs against National League opponents following a win.
• The Dodgers have lost each of their last five Thursday night games as favorites against NL West opponents.
• The Giants have covered the run line in seven of their last eight games as road underdogs.
• The Dodgers have failed to cover the run line in six of their last seven home games against the Giants following a win.
• The Giants have won the first inning in each of their last four night games against opponents that held a winning record.
• The Giants have led after 3 innings in each of their last five night games against opponents that held a winning record.

Total Runs Facts

• Five of the Dodgers’ last six games after playing the previous day have gone OVER the total runs line.
• Nine of the Giants’ last 11 night games after playing the previous day have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in eight of the Dodgers’ last nine night games at Dodger Stadium.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Giants’ last five night games.

Los Angeles Dodgers Player Prop Facts

• Shohei Ohtani has hit a home run in three of the Dodgers’ last four night games.
• Andy Pages has recorded at least one hit in each of his last 10 home appearances after playing the previous day.
• Freddie Freeman has recorded a Double in four of the Dodgers’ last five games against the Giants.
• Shohei Ohtani ranks 2nd amongst qualified players for Slugging Percentage (.611) this season.

San Francisco Giants Player Prop Facts

• Casey Schmitt has hit a home run in two of the Giants’ last three road games against the Dodgers.
• Logan Webb has recorded seven strikeouts in three of his last four appearances.
• Dominic Smith has recorded a Double in three of his last four road appearances against the Dodgers.
• Logan Webb has recorded a win in each of his last four appearances with the Giants as underdogs.
• Dominic Smith has recorded at least one hit in 20 of his last 22 appearances in night games.
• Logan Webb ranks 4th in the league for total Strikeouts (206) this season.

Matchup/League Facts

• The Dodgers rank 2nd in the league for runs scored this season (773).
• The Dodgers rank 2nd in the league for home runs this season (223).
• The Giants rank 1st in the league for home runs allowed this season (129).
• The Giants rank 29th in the league for steals this season (65).

San Francisco Giants vs. Los Angeles Dodgers Prediction

I’m on the Dodgers here. Yamamoto has had some slight issues in his career against the Dodgers, but it’s nothing compared to the issues that Logan Webb has had opposite the Los Angeles Dodgers. The Dodgers are still a potent lineup and while the Giants have played well as of late and got themselves back in the wild card hunt, Logan Webb has just been struggling overall and against a Dodgers lineup that’s had his number, I don’t see it getting any better here. Give me the Dodgers.