Jun 7, 2025; Chicago, Illinois, USA;  Chicago White Sox pitcher Adrian Houser (57) delivers during the first inning against the Kansas City Royals  at Rate Field. Mandatory Credit: Matt Marton-Imagn Images

San Francisco Giants vs Chicago White Sox Prediction 06/28/2025 Picks

Pick details

San Francisco (45-37) vs Chicago (26-56)

June 28, 2025 at 04:10 PM EDT

The Line: Betting Odds: Chicago +1.5 — Over/Under: +8

(Get latest betting odds)

In this article, we will formulate a Giants vs White Sox prediction for this MLB game on Saturday, June 28, at Rate Field in Chicago, Illinois. Let’s take a look at the prediction for this MLB matchup.

San Francisco Giants Betting Preview

The San Francisco Giants (45-37, 20-20 Away) played at home the last three series, losing to the Cleveland Guardians, beating the Boston Red Sox, and being surprisingly swept by the Miami Marlins in three games. San Francisco avoided its fourth consecutive defeat with a 3-1 victory over the White Sox in Game 1 of the current series. Patrick Bailey led the offense with two RBI, while Landen Roupp got the win after allowing one run (not earned) on seven hits with four strikeouts and two walks across 5.1 innings of work.

This season, the Giants average 4.23 runs per game (19th in the MLB) on a .232/.313/.375 triple-slash. When it comes to pitching, the Giants’ staff has a 3.38 ERA (3rd) and 1.24 WHIP (11th). Wilmer Flores leads the Giants with a .243 batting average, 11 home runs, and 55 RBI this season.

Robbie Ray will take the mound for the Giants on Saturday. The 33-year-old left-hander has an 8-2 record in 16 starts this year with a 2.83 ERA and 1.16 WHIP in 92.1 innings.

Chicago White Sox Betting Preview

The Chicago White Sox (26-56, 17-24 Home) beat the Toronto Blue Jays in two out of three games on the road, but then suffered a couple of home losses to the Arizona Diamondbacks. Although they avoided a sweep with a win in Game 3, the White Sox lost Game 1 of this series against the Giants. Aaron Civale pitched for 4.0 innings in a no-decision, allowing one run on three hits with four strikeouts and four walks. Tyler Alexander took the loss.

This year, the White Sox average 3.43 runs per game (28th in the MLB) on a .220/.293/.343 triple-slash. When it comes to pitching, the White Sox’s staff has a 4.18 ERA (22nd) and 1.40 WHIP (26th). Miguel Vargas leads the White Sox with a .234 batting average, ten home runs, and 34 RBI this season.

The projected starting pitcher for the White Sox is Adrian Houser, who is 2-2 in six starts this season, with a 2.27 ERA and 1.26 WHIP in 35.2 innings.

Total Runs Facts

Nine of the Giants’ last 10 games against AL Central opponents have gone UNDER the total runs line.
Ten of the White Sox’s last 13 home games after playing the previous day have gone OVER the total runs line.
The ‘Inning 1 OVER 0.5 runs’ market has hit in eight of the White Sox’s last nine games against National League opponents.
The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Giants’ last four road games.

Matchup/League Facts

The White Sox rank 29th in the league for slugging percentage this season (.343).
The White Sox rank 29th in the league for on-base percentage this season (.293).
The Giants rank 3rd in the league for ERA this season (3.38).
The Giants rank 26th in the league for hits this season (622).

Giants vs White Sox Prediction

The teams have traded victories in the past couple of years, each recording five in the previous ten H2H encounters. Although I am leaning toward the Giants in this one, I’ll avoid betting on the winner and will opt for Under instead. I like this pitching matchup for such a bet. Robbie Ray’s numbers are perhaps not as good in June as they were in May, but he still registered two quality starts of four this month, and hasn’t allowed more than three runs in a game. He will keep the hosts to one or two runs in the opening five or six innings here. Adrian Houser, on the other hand, is a pleasant surprise this season, as five of his six starts were quality starts, while he hasn’t surrendered more than three runs in a game. Expect a low-scoring offense with a lot of quality pitches and solid defense.

Oliver Zivic's Pick: Under 8.5

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