San Diego Padres vs Milwaukee Brewers Prediction 6/7/25 MLB Picks

The San Diego Padres and Milwaukee Brewers meet Saturday in MLB action at American Family Field. Here’s a San Diego Padres vs Milwaukee Brewers Prediction. This article will include a San Diego Padres vs Milwaukee Brewers Pick.

San Diego Padres Betting Preview

The San Diego Padres are 36-26 on the year and play the Dodgers, Diamondbacks, and Dodgers next. The San Diego Padres are batting .249 on the season, have a .314 OBP, and a .379 slugging percentage. The San Diego Padres pitching staff has a 3.50 ERA and a 1.20 WHIP. Manny Machado leads the San Diego Padres with 73 hits and 32 RBI, while Fernando Tatis Jr. and Luis Arraez have combined for 126 hits and 50 RBI. 

Stephen Kolek gets the ball for the San Diego Padres, and he is 3-1 with a 3.47 ERA and 27 strikeouts this season. Kolek is 1-0 with a 0.00 ERA and 2 strikeouts in his career against the Milwaukee Brewers.

Milwaukee Brewers Betting Preview

The Milwaukee Brewers are 34-30 on the year and play the Braves, Cardinals, and Cubs next. The Milwaukee Brewers are batting .237 on the season, have a .315 OBP, and a .365 slugging percentage. The Milwaukee Brewers’ pitching staff has a 3.88 ERA and a 1.32 WHIP. Jackson Chourio leads the Milwaukee Brewers with 71 hits and 37 RBI, while Sal Frelick and Brice Turang have combined for 126 hits and 46 RBI.

Jose Quintana gets the ball for the Milwaukee Brewers, and he is 4-1 with a 2.77 ERA and 27 strikeouts this season. Quintana is 3-0 with a 4.25 ERA and 31 strikeouts in his career against the San Diego Padres.

Why the Milwaukee Brewers will win

• The Brewers have won eight of their last nine games after playing the previous day.
• The Padres have lost three of their last four road games following a road win.
• The Brewers have covered the run line in seven of their last eight games as favorites following a home loss.
• The Padres have failed to cover the run line in four of their last five games following a road win.

Why the San Diego Padres will win

• The Padres have won eight of their last 10 games as underdogs against National League opponents.
• The Brewers have lost three of their last four games as home favorites against NL West opponents.
• The Padres have covered the run line in 11 of their last 12 games as underdogs against National League opponents.
• The Brewers have failed to cover the run line in seven of their last eight home games against NL West opponents.
• The Padres have led after 3 innings in five of their last six night games against the Brewers.
• The Padres have led after 5 innings in four of their last five night games against the Brewers.

Milwaukee Brewers Player Prop Facts

• Christian Yelich has hit at least one home run in three of the Brewers’ last five night games.
• Brice Turang has recorded at least one RBI in four of the Brewers’ last five games against the Padres.
• Jose Quintana has recorded a win in three of his last four appearances with his team as a home favorite .
• Christian Yelich has scored at least one run in six of his last seven appearances with the Brewers as favorites against NL West opponents.
• Jose Quintana has recorded four or more strikeouts in each of his 12 previous Saturday appearances in night games with his team as a favorite.
• Sal Frelick has recorded at least one hit in each of his last 15 appearances with the Brewers as home favorites.
• Sal Frelick has recorded at least one Single in each of the Brewers’ last seven games as home favorites against NL opponents.

San Diego Padres Player Prop Facts

• Manny Machado has hit a home run in each of the Padres’ last two games as underdogs.
• Manny Machado has recorded at least one RBI in seven of the Padres’ last eight games as road underdogs against NL opponents.
• Manny Machado has scored a run in six of the Padres’ last seven games against NL Central opponents.
• Jake Cronenworth has recorded at least one hit in 14 of his last 15 appearances against NL Central opponents that held a winning record.
• Luis Arraez has recorded at least one Single in each of the Padres’ last six games against NL Central opponents that held a winning record.
• Manny Machado ranks 9th amongst qualified players for Batting Average (.316) this season.

San Diego Padres vs Milwaukee Brewers Prediction

The Padres and the cheap price is appealing, but Kolek still has more to prove with just six career starts under his belt. The Brewers haven’t lost two straight games since May 24, and Quintana has found the fountain of youth at 36 years old. Through 39 innings, Quintana has allowed 35 hits and 12 earned runs. The Brewers have won five of Quintana’s seven games this season. Obviously we need to see a larger sample size before we can really crown Quintana, and he’s pitched just once over the last month. I’m still rolling with the Brewers at home in this near toss-up matchup.

Randy Chambers's Pick: Milwaukee Brewers -115