Red Sox vs Tigers Prediction 5/6/2026 Today’s MLB Picks

In this article we will formulate a Red Sox vs Tigers prediction for this MLB game on Wednesday, May 6th at Comerica Park in Detroit, Michigan. Let’s take a look at the prediction for this MLB matchup. 

Boston Red Sox Betting Preview

The Boston Red Sox are 15-21 this season after they won the first two games in this series by scores of 5-4 and 10-3. In game two, Boston scored three runs in the first inning and they never looked back in the blowout win. The Red Sox recorded 12 hits in the game and they were led by Rafaela, who went 3-5 with one home run and four RBIs. Bello allowed four hits and one earned run over 7.0 innings for the win, while Gamboa closed out the game. Prior to this series, Boston lost two out of three against the Astros and two out of three against the Blue Jays. 

This season, Boston has a 4.11 ERA with a 1.31 WHIP and a .246 opponent batting average, while they have scored 145 runs with a .240 batting average and a .318 on base percentage. Willson Contreras has led the Red Sox with eight home runs and 22 RBIs, while Jarren Duran has added four home runs and 18 RBIs. The projected starting pitcher for Boston is Sonny Gray, who is 2-1 with a 4.30 ERA and a 1.30 WHIP over 23.0 innings pitched this season. 

Detroit Tigers Betting Preview

The Detroit Tigers are 18-19 this year after they lost game two by a score of 10-3 on Tuesday night. Detroit cut the deficit to 3-2 in the bottom of the first, but they allowed the next seven runs in the ugly loss. The Tigers recorded seven hits and they committed one error in the game, while they were led by Vierling, who went 2-4 with one home run and one RBI. Valdez allowed nine hits and seven earned runs over 3.0 innings for the loss, while Hanifee allowed zero earned runs over 3.0 innings in relief. Prior to this series, Detroit won two out of three against the Rangers, but lost two out of three against the Braves before that. 

This season, Detroit has a 3.93 ERA with a 1.32 WHIP and a .243 opponent batting average, while they have scored 165 runs with a .247 batting average and a .327 on base percentage. Dillon Dingler has led the Tigers with six home runs and 26 RBIs, while Riley Greene has added four home runs and 19 RBIs. The projected starting pitcher for Detroit is Jack Flaherty, who is 0-2 with a 5.90 ERA and a 1.79 WHIP over 29.0 innings pitched this year. 

Why the Detroit Tigers will win

• The Tigers have won eight of their last 10 games at Comerica Park against AL East opponents that held a losing record.
• The Red Sox have lost four of their last five games against American League opponents that held a losing record.
• The Red Sox have failed to cover the run line each of their last six Wednesday games against American League opponents that held a losing record.
• The Tigers have covered the run line in seven of their last nine games against the Red Sox.

Why the Boston Red Sox will win

• The Red Sox have won each of their last four games at Comerica Park against teams that held a losing record.
• The Tigers have lost six of their last seven home games against AL East opponents.
• The Tigers have failed to cover the run line in 15 of their last 16 Wednesday games against American League opponents that held a losing record.
• The Red Sox have covered the run line each of their last four games at Comerica Park against American League opponents that held a losing record.

Total Runs Facts

• Each of the last four games between the Red Sox and Tigers have gone OVER the total runs line.
• Six of the Red Sox’s last seven road games against AL Central opponents have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Red Sox’s last 10 Wednesday night games against American League opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in four of the last five games between the Red Sox and Tigers at Comerica Park.

Detroit Tigers Player Prop Facts

• Jack Flaherty has recorded six or more strikeouts in each of his last four appearances in night games against AL East teams that held a losing record.
• Riley Greene has recorded at least one hit in each of the Tigers’ last seven home games against the Red Sox.
• Spencer Torkelson has hit a home run in three of the Tigers’ last seven home games.

Boston Red Sox Player Prop Facts

• Jarren Duran has hit a home run in each of the Red Sox’s last two road games against AL Central opponents that held a losing record.
• Connor Wong has recorded at least one hit in each of his last eight road appearances against AL Central opponents that held a losing record.

Red Sox vs Tigers Prediction 

Detroit comes into this matchup trying to snap their two game losing streak, but they have allowed five runs or more in three of their last five games. The Tigers are 12-5 at home this year, while the Red Sox are 9-11 on the road. Boston has won three of their last five games and they are starting Gray, who is expected to come off of the IL. Detroit is going with Flaherty, who has allowed 10 earned runs and 10 hits over his last 5.2 innings. Take the over here.

David Racey's Pick: Over 8