Red Sox vs Orioles Prediction 4/25/2026 Today’s MLB Picks

In this article we will formulate a Red Sox vs Orioles prediction for this MLB game on Saturday, April 25th at Camden Yards in Baltimore, Maryland. Let’s take a look at the prediction for this MLB matchup. 

Boston Red Sox Betting Preview

The Boston Red Sox are 9-17 this year after they lost game one by a score of 10-3 on Friday night. Boston allowed eight of the first nine runs in the game and never had a chance in the blowout loss. The Red Sox recorded 10 hits in the game and they were led by Mayer, Abreu, and Rafaela, who all had one RBI. Bello allowed 13 hits and eight earned runs over 3.1 innings for the loss, while Moran allowed one earned run in relief. Prior to this series, Boston lost all three against the Yankees and split four games with the Tigers. 

This season, Boston has a 4.61 ERA with a 1.38 WHIP and a .254 opponent batting average, while they have scored 95 runs with a .226 batting average and a .306 on base percentage. Wilson Contreras has led the Red Sox with four home runs and 12 RBIs, while Trevor Story has added two home runs and 17 RBIs. The projected starting pitcher for Boston is Garrett Crochet, who is 2-3 with a 7.88 ERA and a 1.63 WHIP over 24.0 innings pitched this year. 

Baltimore Orioles Betting Preview

The Baltimore Orioles are 13-13 this season after they won game one by a score of 10-3 last night. Baltimore scored four runs in the first inning and they never looked back in the easy victory. The Orioles recorded 20 hits in the game and they were led by Rutschman, who went 3-5 with two home runs and six RBIs. Young allowed seven hits and three earned runs over 5.2 innings for the win, while Foster threw two scoreless innings in relief. Prior to this series, Baltimore won two out of three against the Royals, but lost three out of four against the Guardians before that. 

This season, Baltimore has a 3.96 ERA with a 1.36 WHIP and a .253 opponent batting average, while they have scored 121 runs with a .242 batting average and a .328 on base percentage. Gunnar Henderson has led the Orioles with eight home runs and 16 RBIs, while Jeremiah Jackson has added five home runs and 19 RBIs. The projected starting pitcher for Baltimore is Trevor Rogers, who is 2-2 with a 4.08 ERA and a 1.33 WHIP over 28.2 innings pitched this season. 

Why the Baltimore Orioles will win

• The Red Sox have lost each of their last six games against AL East opponents.
• The Orioles have won each of their last four day games against teams that held a losing record.
• The Red Sox have failed to cover the run line in each of their last seven games as underdogs after playing the previous day.
• The Orioles have covered the run line each of their last six games against American League opponents that held a losing record.
• The Red Sox have trailed after 3 innings in three of their last four games.
• The Orioles have led after 5 innings in four of their last five games as home favorites against AL East opponents.
• The Orioles have won the first inning in three of their last four games as home favorites against AL East opponents.

Why the Boston Red Sox will win

• The Orioles have lost each of their last 11 Saturday games against American League opponents.
• The road team has won eight of the last nine games between the Red Sox and Orioles.
• The Orioles have failed to cover the run line in seven of their last eight games as home favorites against American League opponents following a win.
• The Red Sox have covered the run line in each of their last seven Saturday games as road underdogs against American League opponents.

Total Runs Facts

• Seven of the Red Sox’s last eight games against AL East opponents have gone UNDER the total runs line.
• Each of the Orioles’ last five games against American League opponents have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in 10 of the Orioles’ last 11 games as home favorites against AL East opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in eight of the Red Sox’s last nine road games against American League opponents.

Red Sox vs Orioles Prediction 

Baltimore was able to blow out Boston in game one on Friday night and they have scored a total of 30 runs in their last four games. The Orioles are 7-6 at home this year, while the Red Sox are 4-9 on the road. Boston has lost four in a row and they have been outscored 22-6 in that span. The Red Sox are starting Crochet, who has allowed 15 earned runs in his last 6.2 innings, while Rogers has allowed nine earned runs and 15 hits in his last 9.2 innings. Take the over here.

David Racey's Pick: Over 8