Jun 24, 2025; Milwaukee, Wisconsin, USA; Milwaukee Brewers shortstop Joey Ortiz (3) gets the post game dunk after beating the Pittsburgh Pirates at American Family Field. Mandatory Credit: Benny Sieu-Imagn Images

Pittsburgh Pirates vs Milwaukee Brewers Prediction 06/25/2025 Picks

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Pittsburgh (32-49) vs Milwaukee (44-36)

June 25, 2025 at 02:10 PM EDT

The Line: Betting Odds: Milwaukee +1.5 — Over/Under: +6.5

(Get latest betting odds)


The Pittsburgh Pirates and Milwaukee Brewers meet Wednesday in MLB action at American Family Field. Here’s a Pittsburgh Pirates vs Milwaukee Brewers Prediction. This article will include a Pittsburgh Pirates vs Milwaukee Brewers Pick.

Pittsburgh Pirates Betting Preview

The Pittsburgh Pirates are 32-49 on the year and play the Mets, Cardinals, and Mariners next. The Pittsburgh Pirates are batting .229 on the season, have a .303 OBP, and a .339 slugging percentage. The Pittsburgh Pirates pitching staff has a 3.86 ERA and a 1.21 WHIP. Bryan Reynolds leads the Pittsburgh Pirates with 68 hits and 39 RBI, while Andrew McCutchen and Ke’Bryan Hayes have combined for 128 hits and 50 RBI. 

Paul Skenes gets the ball for the Pittsburgh Pirates, and he is 4-6 with a 1.85 ERA and 106 strikeouts this season. Skenes is 1-0 with a 0.69 ERA and 19 strikeouts in his career against the Milwaukee Brewers.

Milwaukee Brewers Betting Preview

The Milwaukee Brewers are 44-36 on the year and play the Rockies, Mets, and Marlins next. The Milwaukee Brewers are batting .247 on the season, have a .322 OBP, and a .380 slugging percentage. The Milwaukee Brewers pitching staff has a 3.86 ERA and a 1.30 WHIP. Jackson Chourio leads the Milwaukee Brewers with 87 hits and 46 RBI while Sal Frelick and Brice Turang have combined for 163 hits and 62 RBI.

Jacob Misiorowski gets the ball for the Milwaukee Brewers, and he is 2-0 with a 1.64 ERA and 11 strikeouts this season. This will be Misiorowski’s first career game against the Pittsburgh Pirates.

Why the Milwaukee Brewers will win

The Brewers have won each of their last four games as underdogs after playing the previous day.
The Pirates have lost four of their last five games as favorites against NL Central opponents.
The Pirates have failed to cover the run line in eight of their last nine games as favorites against NL Central opponents.
The Brewers have covered the run line in each of their last four games as underdogs.
The Pirates have trailed after 3 innings in each of their last three day games.

Why the Pittsburgh Pirates will win

The Brewers have lost each of their last five day games against National League opponents following a home win.
The Pirates have won five of their last six games against National League opponents following a loss.
The Brewers have failed to cover the run line in each of their last nine home games against National League opponents following a home win.
The Pirates have covered the run line in each of their last six day games against NL Central opponents.

Milwaukee Brewers Player Prop Facts

Christian Yelich has hit a home run in two of the Brewers’ last three home games against NL Central opponents.
Brice Turang has recorded a Double in three of the Brewers’ last four day games.
Christian Yelich has recorded at least one hit in each of his last 14 appearances against opponents that held a losing record.

Pittsburgh Pirates Player Prop Facts

Andrew McCutchen has hit a home run in three of his last seven road appearances against NL opponents that held a winning record.
Isiah Kiner-Falefa has recorded at least one hit in each of the Pirates’ last nine games against the Brewers.
Oneil Cruz ranks 2nd in the league in Steals (26) this season.

Pittsburgh Pirates vs Milwaukee Brewers Prediction

The Pirates are going to get love from oddsmakers because Skenes is on the mound. Arguably the best pitcher in the sport, Skenes has a 1.85 ERA and 0.88 WHIP on the season, and he’s allowed three earned runs in his last 26.2 innings. Skenes has a 1.28 ERA and .171 allowed batting average in 56.1 road innings. However, Misiorowski has allowed one hit and two runs in 11 MLB innings, proving why he’s a highly touted prospect. The Brewers are also the better team overall. I’ll take a stab with the Brewers on Thursday afternoon.

Randy Chambers's Pick: Milwaukee Brewers

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