Pittsburgh Pirates vs Chicago White Sox Prediction 9/10/2026 Today’s MLB Picks

In this article, we will formulate a Pirates vs White Sox Prediction for this MLB matchup on Thursday, September 10th in the third game of this series. Let’s take a look at the prediction for this MLB matchup.

Chicago White Sox Preview

The Chicago White Sox have a 75-70 record this season and are sitting in the 1st place of the AL Central. They have a 43-30 home record and are coming off a 2-4 home loss against the Pirates. They will face the Cardinals and the Guardians next.

The Chicago White Sox have a .236 batting average this season, .319 OBP and .407 Slugging percentage. Chicago’s pitching staff has a 4.14 ERA and 1.31 WHIP. Chase Meidroth is the team’s best hitter with a .268 batting average. Colson Montgomery leads the team in RBI with 83, while Munetaka Murakami adds a team-high 31 home runs.

Hagen Smith (L) is the projected starting pitcher for the White Sox, and he has a 3-1 record, 0.56 ERA and 0.94 WHIP.

Pittsburgh Pirates Preview

The Pittsburgh Pirates have a 73-73 record this season and are sitting in the 3rd place of the NL Central. They have a 35-39 road record and are coming off a 4-2 road win against the White Sox. They will face the Cubs and the Brewers next.

The Pittsburgh Pirates have a .254 batting average this season, .331 OBP and .403 Slugging percentage. Pittsburgh’s pitching staff has a 4.15 ERA and 1.30 WHIP. Nick Gonzales is the team’s best hitter with a .305 batting average. Brandon Lowe leads the team in RBI with 83, adding a team-high 29 home runs.

Jared Jones (R) is the projected starting pitcher for the Pirates, and he has a 3-6 record, 4.46 ERA and 1.23 WHIP.

Pittsburgh Pirates @ the Chicago White Sox Betting Trends: September 10, 2026

• Probable Starting Pitcher: Hagen Smith      Record this season: 3-1      ERA: 0.56
• Home Record: 2-0
• Last 5 against Pirates: –

Why the Chicago White Sox will win

• The White Sox have won eight of their last nine games following a home loss.
• The Pirates have lost seven of their last nine road games against AL opponents following a road win.
• The White Sox have covered the run line in eight of their last nine night games following a home loss.
• The Pirates have failed to cover the run line in four of their last five games against AL opponents after playing the previous day.

• Probable Starting Pitcher: Jared Jones      Record this season: 3-6      ERA: 4.46
• Road Record: 2-3
• Last 5 against White Sox: –

Why the Pittsburgh Pirates will win

• The road team has won each of the last eight games between the Pirates and White Sox.
• The White Sox have lost each of their last four night games against NL Central opponents.
• The road team has covered the run line in each of the last 10 games between the Pirates and White Sox.
• The White Sox have failed to cover the run line in each of their last four games against NL opponents.
• The Pirates have led after 5 innings in each of their last nine games against AL Central opponents that held a winning record.
• The White Sox have lost the first inning in three of their last four night games against NL Central opponents.
• The Pirates have led after 3 innings in six of their last seven night games against AL Central opponents that held a winning record.

Total Runs Facts

• Each of the Pirates’ last five games after playing the previous day have gone UNDER the total runs line.
• Seven of the White Sox’s last nine home games against NL Central opponents have gone OVER the total runs line.
• There has been no run scored during the first inning in nine of the Pirates’ last 10 road games against AL Central opponents.
• There has been no run scored during the first inning in five of the last six night games between the Pirates and White Sox at Rate Field.

Chicago White Sox Player Prop Facts

• Sam Antonacci has recorded at least one hit in each of the White Sox’s last seven home games against NL Central opponents.
• Kyle Teel has hit a home run in two of the White Sox’s last three games.
• Colson Montgomery ranks T10th in the league in Home Runs (31) this season.

Pittsburgh Pirates Player Prop Facts

• Jared Jones has recorded seven or more strikeouts in each of his last three appearances against AL opponents.
• Nick Gonzales has recorded at least one hit in each of his last 11 road appearances against AL opponents that held a winning record.
• Esmerlyn Valdez has hit a home run in each of his last two road appearances after playing the previous day.
• Nick Gonzales ranks 5th amongst qualified players for Batting Average (.305) this season.

Matchup/League Facts

• The White Sox rank 6th in the league for runs scored this season (685).
• The White Sox rank 6th in the league for home runs this season (190).
• The Pirates rank 2nd in the league for home runs allowed this season (141).
• The Pirates rank 3rd in the league for hits this season (1273).

Pirates vs White Sox Prediction

The Pirates are 6-3 in their last 9 meetings against the White Sox, having won their last five visits in Chicago.

In this Pirates vs White Sox Prediction, both teams are coming at a pickem price. The Pirates have won both games in this series and have been in very good shape, with an 8-2 record in their last 10 games. Jared Jones has been unstable lately, but this is the far safer pitching option today as the White Sox are going for a bullpen game. The Pirates have also a superior offense in their last 10 games, with the White Sox scoring just 3.5 runs per game in that span. Take the Pirates to win this one on the road.

Nikos Lagouretos's Pick: Pittsburgh Pirates ML