Pirates vs Reds Prediction 9/23/2025 Today’s MLB Picks

In this article we will formulate a Pirates vs Reds prediction for this MLB game on Tuesday, September 23rd at Great American Ball Park in Cincinnati, Ohio. Let’s take a look at the prediction for this MLB matchup. 

Pittsburgh Pirates Betting Preview

The Pittsburgh Pirates are 67-89 this year after they won two out of three against the Athletics by scores of 3-4, 2-0, and 11-0. In their game three win, Pittsburgh jumped out in front in the first inning and never looked back in the blowout victory. The Pirates recorded 15 hits in the game and they were led by Bart and Triolo, who both had three RBIs in the win. Pittsburgh started Burrows, who allowed five hits and zero earned runs over 4.0 innings, while Mlodzinski picked up the win in relief. 

Prior to that series, the Pirates lost all three against the Cubs and two out of three against the Nationals. Pittsburgh has lost 12 of their last 15 games and they are last in the NL Central standings. The Pittsburgh pitching staff has a 3.82 ERA with a 1.22 WHIP and a .236 opponent batting average, while their offense has scored 561 runs with a .231 batting average and a .305 on base percentage this season. Oneil Cruz has led Pittsburgh with 19 home runs and 59 RBIs, while Bryan Reynolds has added 16 home runs and 73 RBIs this year. The projected starting pitcher for Pittsburgh is Johan Oviedo, who is 2-0 with a 3.52 ERA and a 1.24 WHIP over 30.2 innings pitched this year. 

Cincinnati Reds Betting Preview

The Cincinnati Reds are 80-76 this season after they won all four games against the Cubs by scores of 1-0, 7-4, 6-3, and 1-0. In their game four win, Cincinnati scored the only run of the game in the third inning and hung on for the victory. The Reds recorded five hits in the game and they were led by Lux, who went 2-4 with one RBI in the win. Cincinnati started Abbott, who allowed five hits and zero earned runs over 4.2 innings, while Martinez picked up the win and Santillan got the save. 

Prior to that series, the Reds won two out of three against the Cardinals, but lost all three against the Athletics before that. Cincinnati has won five games in a row and they are third in the NL Central standings. The Cincinnati pitching staff has a 3.91 ERA with a 1.23 WHIP and a .235 opponent batting average, while their offense has scored 697 runs with a .245 batting average and a .315 on base percentage this season. Elly De La Cruz has led Cincinnati with 20 home runs and 83 RBIs, while Spencer Steer has added 21 home runs and 74 RBIs this year. The projected starting pitcher for Cincinnati is Brady Singer, who is 14-10 with a 3.86 ERA and a 1.22 WHIP over 161.0 innings pitched this season.

Why the Reds will beat the Pirates 

The Pirates have lost each of their last seven games against NL Central opponents.
The Reds have won each of their last six games at Great American Ball Park.
The Pirates have failed to cover the run line each of their last six games against teams that held a winning record.
The Reds have covered the run line in five of their last six games as home favorites against the Pirates.
The Reds have led after 3 innings in each of their last three night games against the Pirates at Great American Ball Park.
The Pirates have trailed after 5 innings in six of their last seven night games at Great American Ball Park against National League opponents.

Total Runs Facts

Each of the Pirates’ last six night games as underdogs have gone UNDER the total runs line.
Five of the Reds’ last six games as favorites against National League opponents have gone UNDER the total runs line.
The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Reds’ last four games as home favorites against National League opponents.
The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Pirates’ last six Tuesday night games.

Cincinnati Reds Player Prop Facts

Spencer Steer has hit a home run in three of his last five appearances against NL Central opponents that held a losing record.
Brady Singer has recorded six or more strikeouts in five of his last six home appearances.
Brady Singer has recorded a win in each of his last five appearances at Great American Ball Park.
Miguel Andujar has recorded at least one hit in each of his seven previous home appearances against NL Central opponents that held a losing record.

Pittsburgh Pirates Player Prop Facts

Johan Oviedo has recorded five or more strikeouts in each of his last five appearances with the Pirates as road underdogs.
Joey Bart has hit a home run in each of his last two appearances after not playing the previous day.
Tommy Pham has recorded at least one hit in 12 of his last 13 road appearances against former teams. 

Pirates vs Reds Prediction 

Cincinnati comes into this matchup playing very well and they are in the middle of the race for the last wild card spot in the NL. The Reds are 44-34 at home this year, while the Pirates are 23-52 on the road. Pittsburgh did just win a series against the A’s and they are starting Oviedo, who has allowed two earned runs or fewer in four of his last five outings. Cincinnati is going with Singer, who has also allowed two earned runs or fewer in four of his last five. The pitching matchup is pretty even, but I trust the Reds at the plate much more. Take Cincinnati here.