Milwaukee Brewers right fielder Sal Frelick (10) hits a sacrifice fly during the fourth inning of their game against the Pittsburgh Pirates Saturday, April 25, 2026 at American Family Field in Milwaukee, Wisconsin.
Mark Hoffman/Milwaukee Journal Sentinel / USA TODAY NETWORK via Imagn Images

Pirates vs Brewers Prediction 4/26/2026 Today’s MLB Picks

Pick details

MATCHUP Pittsburgh Pirates Milwaukee Brewers
Team Records 16-11 13-13
Spread +1.5 -199 -1.5 163
Moneyline +109 -131
Total Over 7.5 (-115) Under 7.5 (-105)
Where American Family Field, Milwaukee, Wisconsin
When Sunday, April 26, 2026
Time 02:10 PM EDT
TV ESPN Unlmtd

In this article we will formulate a Pirates vs Brewers prediction for this MLB game on Sunday, April 26th at American Family Field in Milwaukee, Wisconsin. Let’s take a look at the prediction for this MLB matchup. 

Pittsburgh Pirates Betting Preview

The Pittsburgh Pirates are 16-11 this year after they won the first two games in this series by scores of 6-0 and 6-3. In game two, Pittsburgh blew a 3-2 lead in the sixth inning, but they scored three runs in the 10th for the win. The Pirates recorded nine hits and they committed one error in the game, while they were led by Horwitz, who went 1-4 with two RBIs. Keller allowed five hits and three earned runs over 5.0 innings, while Soto picked up the win in relief. Prior to this series, Pittsburgh lost two out of three against the Rangers, but did win two out of three against the Rays before that. 

This season, Pittsburgh has a 3.30 ERA with a 1.24 WHIP and a .218 opponent batting average, while they have scored 135 runs with a .246 batting average and a .330 on base percentage. Oneil Cruz has led the Pirates with eight home runs and 24 RBIs, while Brandon Lowe has added seven home runs and 19 RBIs. The projected starting pitcher for Pittsburgh is Carmen Mlodzinski, who is 1-1 with a 3.28 ERA and a 1.42 WHIP over 24.2 innings pitched this year. 

Milwaukee Brewers Betting Preview

The Milwaukee Brewers are 13-13 this season after they lost game two by a score of 6-3 in extra innings. Milwaukee tied the game at two in the fourth inning and at three in the sixth, but they couldn’t find anymore offense for the loss. The Brewers recorded six hits and they committed one error in the game, while they were led by Frelick, who went 0-0 with two walks and two RBIs. Misiorowski allowed six hits and three earned runs over 6.0 innings, while Zerpa picked up the loss in relief. Prior to this series, Milwaukee lost two out of three against the Tigers, but did win two out of three against the Marlins before that. 

This season, Milwaukee has a 3.97 ERA with a 1.32 WHIP and a .243 opponent batting average, while they have scored 127 runs with a .231 batting average and a .330 on base percentage. Jake Bauers has led the Brewers with five home runs and 15 RBIs, while Garrett Mitchell has added one home run and 19 RBIs. The projected starting pitcher for Milwaukee is Kyle Harrison, who is 1-1 with a 3.06 ERA and a 1.30 WHIP over 17.2 innings pitched this season. 

Why the Milwaukee Brewers will win

  • The Brewers have won each of their last seven day games against NL Central opponents following a loss.
  • The Pirates have lost each of their last six road games following an extra innings win.
  • The favorites have covered the run line in seven of the last eight games between the Pirates and Brewers.
  • The Pirates have failed to cover the run line in three of their last four games against the Brewers following a road win.
  • The Pirates have trailed after 5 innings in three of their last four day games at American Family Field against National League opponents.

Why the Pittsburgh Pirates will win

  • The Brewers have lost each of their last seven home games against National League opponents.
  • The underdogs have won six of the Brewers’ last eight games at American Family Field.
  • The Pirates have covered the run line in each of their last seven games against NL Central opponents.
  • The Brewers have failed to cover the run line in 13 of their last 14 home games against National League opponents after playing the previous day.
  • The Pirates have led after 3 innings in four of their last five road day games.

Total Runs Facts

  • Five of the Pirates’ last six road games after going to extra innings have gone UNDER the total runs line.
  • Eight of the Brewers’ last 10 games after going to extra innings have gone UNDER the total runs line.
  • The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Pirates’ last eight Sunday games.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Brewers’ last five games as home favorites.

Milwaukee Brewers Player Prop Facts

  • Christian Yelich has recorded at least one hit in each of his last 10 appearances against the Pirates.
  • Andrew Vaughn has hit a home run in each of his last two appearances with the Brewers as home favorites against NL Central opponents.

Pittsburgh Pirates Player Prop Facts

  • Marcell Ozuna has recorded at least one hit in 16 of his last 18 appearances with his team as a road underdog against the Brewers.
  • Marcell Ozuna has hit a home run in two of the Pirates’ last three day games.

Pirates vs Brewers Prediction 

Pittsburgh has won the first two games in this series and they have scored at least six runs in three of their last four games. The Pirates are 8-6 on the road this year, while the Brewers are 7-7 at home. Milwaukee has lost four in a row and they have allowed 22 runs during that span. The Brewers are starting Harrison, who has allowed two earned runs or fewer in four straight starts, while Mlodzinski has allowed two earned runs or fewer in four of his five starts. Take the under in this one, as the Brewers are struggling at the plate right now.

David Racey's Pick: Under 7.5

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