Philadelphia Phillies vs St. Louis Cardinals Prediction 8/12/2026 Today’s MLB Picks

The Philadelphia Phillies and the St. Louis Cardinals meet Wednesday in MLB action from Busch Stadium. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Philadelphia Phillies vs. St. Louis Cardinals prediction.

Starting Pitching Matchup

The Philadelphia Phillies will send out Zack Wheeler for the start here and Wheeler is 10-3 with a 2.69 ERA and 132 strikeouts this season. Kyle Leahy will start here for the Cardinals and is 8-4 with a 3.45 ERA and 99 strikeouts this season. 

Philadelphia Phillies Recap

The Philadelphia Phillies come into this game looking to bounce back fro their 2-0 loss at the hands of the Cardinals on Tuesday to sit at 64-57 this season. After this series, the Phillies will take on the Minnesota Twins on the road.

Phillies Have Two-Game Win Streak Snapped

Entering Tuesday, Kyle Schwarber has 105 hits with 14 doubles, 35 home runs and 69 RBIs. Brandon Marsh has 116 hits with 17 doubles, 16 home runs and 52 RBIs while Justin Crawford also has 86 hits with 15 doubles, 4 triples, 2 home runs and 30 RBIs. Trea Turner has 119 hits with 20 doubles, 17 home runs and 47 RBIs and Bryce Harper’s added 107 hits with 22 doubles, 25 home runs and 71 RBIs this season.

St. Louis Cardinals Recap

The St. Louis Cardinals come into this game looking to add on to their win over the Phils from Tuesday to improve to 60-60 this season. After this series, the ardinals will take on the Chicago Cubs in a series on the road.

Cardinals Alternate Wins & Losses In 5 Straight

Going into Tuesday, Jordan Walker has 128 hits, 23 doubles, 23 home runs and 83 RBIs while Alec Burleson has 128 hits with 29 doubles, 19 home runs and 81 RBIs. JJ Wetherholt has 108 hits with 16 home runs and 45 RBIs while Ivan Herrera has 112 hits with 23 doubles, 13 home runs and 50 RBIs. Nolan Gorman has 39 hits with 7 home runs and 26 RBIs this season. Masyn Winn’s added 96 hits with 17 doubles and 48 RBIs and Nathan Church has 73 hits with 9 home runs and 37 RBIs this season. 

Philadelphia Phillies @ St. Louis Cardinals Betting Trends: August 12, 2026

• Probable Starting Pitcher: Kyle Leahy      Record this season: 8-4      ERA: 3.45
• Home Record: 4-3
• Last 5 against Phillies: 1-0

Why the St. Louis Cardinals will win

• The Cardinals have won four of their last five games as underdogs against NL East opponents following a home win.
• The Phillies have lost eight of their last 12 games as road favorites against NL Central opponents.
• The Cardinals have covered the run line in each of their last six games against the Phillies.
• The Phillies have failed to cover the run line in seven of their last eight games as road favorites against National League opponents.
• The Cardinals have led after 3 innings in each of their last five day games against National League opponents.

• Probable Starting Pitcher: Zack Wheeler      Record this season: 10-3      ERA: 2.69
• Road Record: 6-1
• Last 5 against Cardinals: 2-2

Why the Philadelphia Phillies will win

• The Phillies have won each of their last eight day games against the Cardinals following a loss.
• The Cardinals have lost each of their last seven day games against teams that held a winning record.
• The Cardinals have failed to cover the run line in each of their last six day games following a win.
• The Phillies have covered the run line in four of their last five day games at Busch Stadium following a loss.
• The Phillies have led after 3 innings in five of their last six day games.
• The Phillies have led after 5 innings in five of their last six road games.

Total Runs Facts

• Twelve of the Cardinals’ last 13 home games against NL East opponents have gone UNDER the total runs line.
• Six of the Phillies’ last seven games have gone OVER the total runs line.
• There has been no run scored during the first inning in each of the Phillies’ last eight games against NL Central opponents.
• There has been no run scored during the first inning in each of the Cardinals’ last six games as home underdogs against NL East opponents.

St. Louis Cardinals Player Prop Facts

• Kyle Leahy has recorded five or more strikeouts in four of his last five appearances against NL opponents.
• Jordan Walker has recorded at least one hit in each of the Cardinals’ last eight day games against opponents that held a winning record.
• Everson Pereira has hit a home run in each of his last two appearances with his team as an underdog.
• Alec Burleson ranks T8th in the league in Hits (129) this season.

Philadelphia Phillies Player Prop Facts

• Zack Wheeler has recorded a win in five of his last six appearances in day games.
• Bryson Stott has recorded at least one hit in each of the Phillies’ last 11 games as favorites against NL opponents.
• Bryan De La Cruz has hit a home run in three of his last seven appearances against the Cardinals.
• Kyle Schwarber ranks T1st in the league in Home Runs (35) this season.

Matchup/League Facts

• The Cardinals rank T27th in the league for doubles this season (168).
• The Cardinals rank 4th in the league for strikeouts against this season (924).
• The Phillies rank 1st in the league for strikeouts this season (1187).
• The Phillies are one of only three teams in the league to rank top 10 in both strikeouts and walks allowed this season.

Philadelphia Phillies vs. St. Louis Cardinals Prediction

I’m leaning towards the under here. Leahy has been a decent option for St. Louis, but the Cardinals don’t do a good job of backing up their starters and I’m looking for that to continue against Zack Wheeler, who has been pitching extremely efficiently himself as of late. All in all, I’m looking for a low-scoring battle here, so give me the under.

Chris Ruffolo's Pick: Under 8