Jun 24, 2025; Houston, Texas, USA; Houston Astros shortstop Jeremy Pena (3) throws a fielded ball to first base to complete a double play against the Philadelphia Phillies during the sixth inning at Daikin Park. Mandatory Credit: Erik Williams-Imagn Images

Philadelphia Phillies vs Houston Astros Prediction 06/25/2025 Picks

Pick details

Philadelphia (47-32) vs Houston (46-33)

June 25, 2025 at 08:10 PM EDT

The Line: Betting Odds: Houston +1.5 — Over/Under: +7.5

(Get latest betting odds)


The Philadelphia Phillies and Houston Astros meet Wednesday in MLB action at Daikin Park. Here’s a Philadelphia Phillies vs Houston Astros Prediction. This article will include a Philadelphia Phillies vs Houston Astros Pick.

Philadelphia Phillies Betting Preview

The Philadelphia Phillies are 47-32 on the year and play the Braves, Padres, and Reds next. The Philadelphia Phillies are batting .256 on the season, have a .331 OBP, and a .404 slugging percentage. The Philadelphia Phillies pitching staff has a 3.86 ERA and a 1.27 WHIP. Trea Turner leads the Philadelphia Phillies with 95 hits and 35 RBI, while Alec Bohm and Nick Castellanos have combined for 170 hits and 77 RBI. 

Zack Wheeler gets the ball for the Philadelphia Phillies, and he is 7-2 with a 2.61 ERA and 118 strikeouts this season. Wheeler is 1-0 with a 1.50 ERA and 13 strikeouts in his career against the Houston Astros.

Houston Astros Betting Preview

The Houston Astros are 46-33 on the year and play the Reds, Rockies, and Dodgers next. The Houston Astros are batting .257 on the season, have a .322 OBP, and a .401 slugging percentage. The Houston Astros pitching staff has a 3.48 ERA and a 1.15 WHIP. Jeremy Pena leads the Houston Astros with 100 hits and 40 RBI while Jose Altuve and Jake Meyers have combined for 155 hits and 54 RBI.

Colton Gordon gets the ball for the Houston Astros, and he is 2-1 with a 4.54 ERA and 34 strikeouts this season. This will be Gordon’s first career game against the Philadelphia Phillies.

Why the Houston Astros will win

The Astros have won each of their last seven games as home underdogs after playing the previous day.
The Phillies have lost three of their last four games as road favorites following a road loss.
The Astros have covered the run line in each of their last seven games as home underdogs after playing the previous day.
The Phillies have failed to cover the run line in nine of their last 11 games as favorites against the Astros following a loss.

Why the Philadelphia Phillies will win

The Phillies have won each of their last four games following a loss.
The Astros have lost five of their last six home games against National League opponents following a home win.
The Phillies have covered the run line in nine of their last 10 games as road favorites against American League opponents following a loss.
The Astros have failed to cover the run line each of their last seven Wednesday night games against teams that held a winning record.
The Astros have trailed after 5 innings in 15 of their last 20 games as home underdogs against NL East opponents.
The Phillies have led after 3 innings in six of their last eight games as road favorites against AL West opponents.

Houston Astros Player Prop Facts

Jeremy Pena has recorded a Double in each of the Astros’ last three games against NL opponents that held a winning record.
Brendan Rodgers has recorded at least one hit in each of his last 12 appearances with his team as a home underdog against NL East opponents.
Chas McCormick has hit a home run in three of his last six appearances against NL East opponents that held a winning record.
Jeremy Pena ranks 5th amongst qualified players for Batting Average (.326) this season.

Philadelphia Phillies Player Prop Facts

Trea Turner has hit a home run in two of the Phillies’ last three games as favorites against AL West opponents.
Zack Wheeler has recorded seven or more strikeouts in nine of his last 10 appearances with the Phillies as favorites.
Max Kepler has recorded at least one hit in 15 of his last 16 appearances against AL West opponents that held a winning record.
Zack Wheeler has recorded a win in each of his last five appearances against AL opponents.
Kyle Schwarber ranks 5th in the league in Home Runs (24) this season.

Philadelphia Phillies vs Houston Astros Prediction

You can make a case for either side as both the Phillies and Astros are playing great ball. The difference here is the Phillies have Wheeler, who has allowed two earned runs in his last 17 innings. Wheeler has a 0.91 WHIP on the season, and he has a 2.86 ERA and .201 allowed batting average in 44 road innings. Gordon has been far more hittable, especially at home where he has a 5.31 ERA and .294 allowed batting average. The Phillies have a clear edge on the mound. Give me the road team.

Randy Chambers's Pick: Philadelphia Phillies

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