Sep 27, 2025; San Diego, California, USA; San Diego Padres second baseman Jake Cronenworth (9) throws over Arizona Diamondbacks catcher Adrian Del Castillo (25) as he turns a double play during the fifth inning at Petco Park. Mandatory Credit: Denis Poroy-Imagn Images
Denis Poroy-Imagn Images

Padres vs Marlins Prediction 7/25/2026 Today’s MLB Picks

Pick details

MATCHUP San Diego Padres Miami Marlins
Team Records 51-53 52-52
Spread +1.5 -181 -1.5 149
Moneyline +113 -136
Total Over 8 (-110) Under 8 (-110)
Where loanDepot park, Miami, Florida
When Saturday, July 25, 2026
Time 04:10 PM EDT
TV MLB.TV

In this article we will formulate a Padres vs Marlins prediction for this MLB game on Saturday, July 25th at loanDepot park in Miami, Florida. Let’s take a look at the prediction for this MLB matchup. 

San Diego Padres Betting Preview

The San Diego Padres are 51-53 this year after they won game one by a score of 4-2 on Friday night. San Diego blew a 2-1 lead in the fifth inning, but they scored two runs in the eighth to get the win. The Padres recorded five hits and they committed one error in the game, while they were led by Rengifo, who went 1-1 with one home run and two RBIs. Marquez allowed three hits and one earned run over 2.1 innings, while Morejon got the win and Miller picked up the save. Prior to this series, San Diego lost three out of four against the Braves and two out of three against the Royals. 

This season, San Diego has a 4.23 ERA with a 1.34 WHIP and a .248 opponent batting average, while they have scored 430 runs with a .229 batting average and a .307 on base percentage. Manny Machado has led the Padres with 22 home runs and 60 RBIs, while Gavin Sheets has added 14 home runs and 41 RBIs. The projected starting pitcher for San Diego is JP Sears, who is 2-3 with a 4.38 ERA and a 1.26 WHIP over 24.2 innings pitched this year. 

Miami Marlins Betting Preview

The Miami Marlins are 52-52 this season after they lost game one by a score of 2-4 last night. Miami led 1-0 in the second inning, but they scored just one run in the last seven innings for the loss. The Marlins recorded nine hits and they committed two errors in the game, while they were led by Mack, who went 1-4 with one home run and one RBI. Gusto allowed two hits and one earned run over 3.1 innings, while Zuber picked up the loss in relief. Prior to this series, Miami lost all three against the Astros and all three against the Brewers. 

This season, Miami has a 4.05 ERA with a 1.25 WHIP and a .229 opponent batting average, while they have scored 459 runs with a .251 batting average and a .326 on base percentage. Liam Hicks has led the Marlins with 14 home runs and 60 RBIs, while Otto Lopez has added nine home runs and 46 RBIs. The projected starting pitcher for Miami is Eury Perez, who is 5-7 with a 3.53 ERA and a 1.11 WHIP over 91.2 innings pitched this season. 

Why the Miami Marlins will win

  • The Padres have lost each of their last six road games following a win.
  • The Marlins have won nine of their last 10 home games against National League opponents.
  • The Marlins have covered the run line in each of their last six day games against the Padres following a loss.
  • The Padres have failed to cover the run line in seven of their last eight day games against NL East opponents.
  • The Padres have trailed after 3 innings in each of their last three games at LoanDepot Park.
  • The Padres have trailed after 5 innings in each of their last three day games at LoanDepot Park against National League opponents.

Why the San Diego Padres will win

  • The Marlins have lost each of their last nine games following a loss.
  • The underdogs have won five of the Marlins’ last six games at LoanDepot Park.
  • The Marlins have failed to cover the run line in each of their last 13 games as home favorites against NL West opponents following a loss.
  • The Padres have covered the run line in each of their last eight games as underdogs.

Total Runs Facts

  • Each of the last four games between the Padres and Marlins have gone UNDER the total runs line.
  • Four of the Padres’ last five day games against NL East opponents have gone OVER the total runs line.
  • There has been no run scored during the first inning in 10 of the Marlins’ last 11 home games.
  • There has been no run scored during the first inning in each of the Padres’ last six Saturday games against NL East opponents.

Miami Marlins Player Prop Facts

  • Joe Mack has hit a home run in three of the Marlins’ last four games.
  • Otto Lopez has recorded at least one hit in each of his last 12 appearances with the Marlins as favorites against NL West opponents.
  • Eury Perez has recorded a win in each of his last three appearances with the Marlins as home favorites against NL opponents.
  • Eury Perez has recorded eight or more strikeouts in three of his last four appearances against opponents that held a losing record.

San Diego Padres Player Prop Facts

  • JP Sears has recorded four or more strikeouts in six of his last seven appearances in day games.
  • Luis Rengifo has hit a home run in two of the Padres’ last three games.
  • Luis Rengifo has recorded at least one hit in each of his last nine appearances with his team as an underdog against NL East opponents.

Padres vs Marlins Prediction 

Miami’s lengthy losing streak continued with a loss on Friday night in game one and they have scored three runs or fewer in four of their last five games. The Marlins are 31-21 at home this year, while the Padres are 24-29 on the road. San Diego has lost three of their last five games and they have scored 5+ runs in three of their last four. The Padres are starting Sears, who has allowed four earned runs in his last 14.1 innings, while Perez has allowed two earned runs or fewer in five straight starts. Take the Marlins to win here.

David Racey's Pick: Marlins ML

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