New York Yankees vs San Francisco Giants Prediction 3/25/2026 Today’s MLB Picks

The New York Yankees and San Francisco Giants meet Wednesday in MLB action at Oracle Park. Here’s a New York Yankees vs. San Francisco Giants Prediction. This article will include a New York Yankees vs. San Francisco Giants Pick.

New York Yankees Betting Preview

The New York Yankees have won 94 games in back-to-back seasons and are a title contender yet again, right behind the Dodgers. For the most part the Yankees are the same team they were a year ago, with Aaron Judge, Cody Bellinger, Jazz Chisholm Jr., etc., leading the way offensively. The rotation is headlined by Max Fried, while the bullpen will be locked down at the back end by David Bednar, Camilo Doval, and Fernando Cruz. The make-or-break part of the season will be the eventual returns of Gerrit Cole and Carlos Rodon. If those guys return to form and can join Fried and Cam Schlittler, forming a super starting rotation, the Yankees can like their chances a lot more to end the World Series drought. Regardless, the offense has elite talent at the top and there’s pitching depth. It’s about staying healthy and striking out less.

Max Fried gets the ball for the New York Yankees, and he was 19-5 with a 2.86 ERA and 189 strikeouts last season. Fried is 4-1 with a 2.68 ERA and 45 strikeouts in his career against the San Francisco Giants.

San Francisco Giants Betting Preview

The San Francisco Giants won 81 games last year and haven’t made the playoffs since the 2021 season. Tony Vitello takes over as manager, while the lineup has two new faces in Luis Arraez and Harrison Bader. The starting rotation added Tyler Mahle and Adrian Houser. Arraez and Bader will help the lineup cut down on swing and misses and also improve the defense. The rotation has one of the best 1-2 punches in the sport with Logan Webb and Robbie Ray. There’s potential with this Giants team. The problems are there are questions with the rest of the rotation and the offense can be suppressed in that big park. Matt Chapman and Rafael Devers have to play like all-star caliber players to really get things going. There’s also playing in the competitive NL West, which doesn’t help. The margin for error with this group is thin. 

Logan Webb gets the ball for the San Francisco Giants, and he was 15-11 with a 3.22 ERA and 224 strikeouts last season. Webb is 1-2 with a 5.50 ERA and 23 strikeouts in his career against the New York Yankees.

Why the San Francisco Giants will win

• The Giants have won each of their last four games.
• The Yankees have lost three of their last five games as road favorites against NL West opponents.
• The Yankees have failed to cover the run line in five of their last six night games against NL West opponents.
• The Giants have covered the run line in four of their last five home games against American League opponents.
• The Yankees have trailed after 5 innings in each of their last three road games.

Why the New York Yankees will win

• The Yankees have won seven of their last eight season openers.
• The Giants have lost 10 of their last 11 games as home underdogs against AL East opponents.
• The Yankees have covered the run line in each of their last five games as favorites against National League opponents.
• The Giants have failed to cover the run line in each of their last four home openers.
• The Giants have trailed after 3 innings in three of their last four games as underdogs against American League opponents.
• The Giants have trailed after 5 innings in each of their last three season openers.

Total Runs Facts

• Seven of the last eight games between the Yankees and Giants have gone OVER the total runs line.
• Six of the Yankees’ last seven games as favorites against the Giants have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Yankees’ last six road games against NL West opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in six of the Giants’ last seven night games at Oracle Park.

San Francisco Giants Player Prop Facts

• Heliot Ramos has recorded at least one hit in each of the Giants’ last 13 Wednesday night games.
• Casey Schmitt has hit a home run in each of the Giants’ last two home games against the Yankees.
• Logan Webb has recorded a win in three of his last four appearances against AL opponents.
• Logan Webb ranked 3rd in the league for total Strikeouts (224) last season.

New York Yankees Player Prop Facts

• Ryan McMahon has recorded a Double in four of his last five appearances in season openers against NL opponents.
• Aaron Judge has hit at least one home run in four of the Yankees’ last five games as road favorites against NL West opponents.
• Max Fried has recorded seven or more strikeouts in six of his last seven appearances with his team as a road favorite against NL West opponents.
• Giancarlo Stanton has recorded at least one hit in each of his last 11 appearances with his team as a favorite against the Giants.
• Max Fried has recorded a win in five of his last six road appearances against NL opponents.
• Max Fried ranked 1st in the league for Wins (19) last season.

Matchup/League Facts

• The Giants ranked 28th in the league for doubles last season (239).
• The Giants ranked 26th in the league for hits last season (1261).
• The Yankees ranked 1st in the league for RBIs last season (820).
• The Yankees ranked 1st in the league for slugging percentage last season (.455).

New York Yankees vs San Francisco Giants Prediction

The Yankees are going to be favored for obvious reasons, as they’re the more talented team from an offensive perspective and Fried is coming off a hell of a season. However, we’ve been backing Webb at Oracle for a couple of years now and it’s worked. In 90 games at Oracle, Webb has a 2.84 ERA, 1.13 WHIP and 522 strikeouts. Last year in 116 home innings, Webb allowed a 3.10 ERA and a .264 batting average and had 126 strikeouts. You’re not going to get Webb as a home dog often the rest of the way and oddsmakers are showing respect, making this line short. Give me the Giants on opening day.

Randy Chambers's Pick: San Francisco Giants