New York Mets vs St. Louis Cardinals Prediction 4/1/2026 Today’s MLB Picks

The New York Mets and St. Louis Cardinals meet Wednesday in MLB action at Busch Stadium. Here’s a New York Mets vs St. Louis Cardinals Prediction. This article will include a New York Mets vs St. Louis Cardinals Pick.

New York Mets Betting Preview

The New York Mets are 3-2 on the year and play the Giants and Diamondbacks next. The New York Mets are batting .228 on the season, have a .333 OBP, and a .351 slugging percentage. The New York Mets pitching staff has a 2.87 ERA and a 1.26 WHIP. Juan Soto leads the New York Mets with 8 hits and 4 RBI, while Luis Robert Jr. and Brett Baty have combined for 10 hits and 8 RBI.

Freddy Peralta gets the ball for the New York Mets, and he is 1-0 with a 7.20 ERA and 7 strikeouts this season. Peralta is 5-6 with a 4.67 ERA and 91 strikeouts in his career against the St. Louis Cardinals.

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 3-2 on the year and play the Tigers and Nationals next. The St. Louis Cardinals are batting .251 on the season, have a .301 OBP, and a .431 slugging percentage. The St. Louis Cardinals pitching staff has a 5.09 ERA and a 1.65 WHIP. Victor Scott II leads the St. Louis Cardinals with 7 hits and 0 RBI while JJ Wetherholt and Alec Burleson have combined for 12 hits and 9 RBI.

Matthew Liberatore gets the ball for the St. Louis Cardinals, and he is 0-0 with a 1.80 ERA and 2 strikeouts this season. Liberatore is 0-2 with a 5.17 ERA and 12 strikeouts in his career against the New York Mets. The Cardinals will face off against the Tigers and Nationals next. 

Why the St. Louis Cardinals will win

• The underdogs have won six of the last eight games between the Mets and Cardinals at Busch Stadium.
• The Mets have lost three of their last four games as favorites after playing the previous day.
• The Cardinals have covered the run line in 10 of their last 12 games as underdogs against NL East opponents.
• The Mets have failed to cover the run line in eight of their last 10 games as road favorites against NL Central opponents.
• The Mets have trailed after 5 innings in eight of their last nine Wednesday games.

Why the New York Mets will win

• The Mets have won each of their last five games following a loss.
• The Cardinals have lost each of their last six Wednesday home games against National League opponents.
• The Cardinals have failed to cover the run line in nine of their last 10 home games against National League opponents following a home win.
• The Mets have covered the run line in each of their last five games following a loss.
• The Mets have led after 5 innings in each of their last three day games against opponents that held a winning record.

Total Runs Facts

• Each of the Mets’ last six games after playing the previous day have gone UNDER the total runs line.
• Each of the Cardinals’ last four home games against NL East opponents have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in seven of the Cardinals’ last eight Wednesday games against National League opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in 15 of the Mets’ last 20 games against National League opponents.

St. Louis Cardinals Player Prop Facts

• Nolan Gorman has hit a home run in two of the Cardinals’ last three home games.
• Lars Nootbaar has recorded two hits in each of his last three appearances against NL East opponents.
• Nolan Gorman ranks T9th in the league in Home Runs (2) this season.

New York Mets Player Prop Facts

• Juan Soto has hit a home run in each of the Mets’ last three Wednesday games.
• Freddy Peralta has recorded eight or more strikeouts in three of his last four appearances in day games against teams that held a winning record.
• Juan Soto has recorded at least one hit in each of his last 11 appearances at Busch Stadium.
• Juan Soto ranks T7th in the league in Hits (8) this season.

Matchup/League Facts

• The Cardinals rank 29th in the league for opponent batting average this season (.290).
• The Cardinals rank 2nd in the league for home runs allowed this season (1).
• The Mets rank 5th in the league for ERA this season (2.87).
• The Mets rank T24th in the league for home runs this season (3).

New York Mets vs St. Louis Cardinals Prediction

Peralta was shaky in his debut with the Mets, and he’s facing a Cardinals lineup that’s hitting .275 with a .333 on base percentage in 69 at bats. Liberatore pitched out of trouble in his debut, but he was hittable, which goes back to last season where he had a .266 allowed batting average in 151.2 innings. Both pitchers can get tagged and with the quick turnaround, I expect to see some offense. I’m looking at the over in this spot.

Randy Chambers's Pick: Over 7.5