Minnesota Twins vs San Diego Padres Prediction 8/22/2026 Today’s MLB Picks

The Minnesota Twins and San Diego Padres meet Saturday in MLB action at Petco Park. Here’s a Minnesota Twins vs San Diego Padres Prediction. This article will include a Minnesota Twins vs San Diego Padres Pick.

Minnesota Twins Betting Preview

The Minnesota Twins are 63-66 on the year and play the Athletics and White Sox next. The Minnesota Twins are batting .246 on the season, with a .321 OBP and a .406 slugging percentage. The Minnesota Twins’ pitching staff has a 4.62 ERA and a 1.38 WHIP. Josh Bell leads the Minnesota Twins with 117 hits and 77 RBI, while Luke Keaschall and Brooks Lee have combined for 219 hits and 103 RBI.

Dean Kremer gets the ball for the Minnesota Twins, and he is 2-4 with a 5.40 ERA and 53 strikeouts this season. Kremer is 0-2 with a 3.00 ERA and 11 strikeouts in his career against the San Diego Padres.

San Diego Padres Betting Preview

The San Diego Padres are 69-60 on the year and play the Pirates and Rays next. The San Diego Padres are batting .238 on the season, have a .315 OBP, and have a .389 slugging percentage. The San Diego Padres’ pitching staff has a 4.05 ERA and a 1.31 WHIP. Fernando Tatis Jr. leads the San Diego Padres with 137 hits and 61 RBI, while Jackson Merrill and Manny Machado have combined for 216 hits and 134 RBI.

Casey Mize gets the ball for the San Diego Padres, and he is 5-7 with a 3.18 ERA and 95 strikeouts this season. Mize is 4-5 with a 5.34 ERA and 53 strikeouts in his career against the Minnesota Twins.

Why the San Diego Padres will win

• The Padres have won each of their last six home games.
• The Twins have lost seven of their last eight road games against National League opponents following a road loss.
• The Padres have covered the run line in each of their last five games at Petco Park.
• The Twins have failed to cover the run line in five of their last six games against NL West opponents.
• The Twins have trailed after 3 innings in five of their last six road games against National League opponents.
• The Padres have won the first inning in three of their last four games at Petco Park against opponents that held a losing record.
• The Twins have trailed after 5 innings in four of their last five games against NL West opponents that held a winning record.

Why the Minnesota Twins will win

• The Twins have won six of their last seven games as underdogs against NL West opponents following a road loss.
• The Padres have lost three of their last four games as favorites against American League opponents following a win.
• The Twins have covered the run line in each of their last 10 games as road underdogs after playing the previous day.
• The Padres have failed to cover the run line in 21 of their last 24 games as favorites following a win.
• The Padres have trailed after 3 innings in seven of their last nine night games against AL Central opponents that held a losing record.

Total Runs Facts

• Seven of the Padres’ last eight games after playing the previous day have gone UNDER the total runs line.
• Five of the Twins’ last six night games after playing the previous day have gone UNDER the total runs line.
• There has been at least one run scored in the first inning in each of the Twins’ last seven games as road underdogs against National League opponents.
• There has been no run scored during the first inning in seven of Casey Mize’s last eight home appearances as a starter.

San Diego Padres Player Prop Facts

• Ty France has hit a home run in each of his last two home appearances against the Twins.
• Casey Mize has recorded a win in three of his last four home appearances against AL Central opponents that held a losing record.
• Casey Mize has recorded five or more strikeouts in four of his last five home appearances.
• Gavin Sheets has recorded at least one hit in each of his last six appearances with his team as a favorite against the Twins.
• Fernando Tatis Jr. ranks 9th in the league in Steals (28) this season.

Minnesota Twins Player Prop Facts

• Byron Buxton has hit a home run in three of his last four Saturday appearances against NL West teams that held a winning record.
• Dean Kremer has recorded five or more strikeouts in four of his last five road appearances against NL opponents that held a winning record.
• Luke Keaschall has recorded at least one hit in each of the Twins’ last eight night games against opponents that held a winning record.

Matchup/League Facts

• The Padres rank T24th in the league for triples this season (11).
• The Padres rank 23rd in the league for slugging percentage this season (.389).
• The Twins rank 26th in the league for runs allowed this season (639).
• The Twins rank 25th in the league for opponent batting average this season (.252).

Minnesota Twins vs San Diego Padres Prediction

The Twins have issues stringing wins together, and Kremer isn’t a pitcher to run to the window to back. Kremer has a 5.40 ERA and 1.18 WHIP, while Mize has a 3.18 ERA and 1.07 WHIP. Mize has settled down in his last two starts, allowing 8 hits and 2 runs in his last 12 innings. I’m going to roll with the Padres on Saturday night.

Randy Chambers's Pick: San Diego Padres