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Minnesota Twins vs Cleveland Guardians Prediction 5/1/25 MLB Picks

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Cleveland Guardians (17-13) vs Minnesota Twins (13-18)

Game Info: Thursday, May 1, 2025 at 1:10 pm (Progressive Field)

The Line: Betting Odds: Cleveland Guardians -112 / Minnesota Twins -108 — Over/Under: 9

(Get latest betting odds)


In this article, we will formulate a Minnesota Twins vs Cleveland Guardians Prediction for this MLB game on Thursday, May 1st, at Progressive Field. To formulate this prediction, we will look at: 

-The Twins’ recent form and recent player performance

-The Guardians’ recent form and recent player performance

-Recent Betting trends and streaks involving Minnesota

-Recent Betting trends and streaks involving Cleveland

-Recent betting trends in games played between Minnesota and Cleveland

-A summary that ties it all together produces a favorable betting outcome for Today’s Game between the Twins and Guardians. 

Twins Back to Struggling

The Twins are back to struggling, and they didn’t give Pablo Lopez any run support on Wednesday. Brooks Lee did hit a home run, but he was the only real bright spot for the offense. Pablo Lopez ended up going 6.1 innings, giving up four hits and two earned runs. He had six strikeouts and zero walks. 

The Twins are averaging 3.93 runs while their pitching staff is giving up 3.7 runs per game. The offense is ranked 20th in the league while the pitching is ranked 8th. As a team, they are batting .233, which is 22nd in the league. Byron Buxton has hit six home runs and driven in 17 RBIs so far this season. Simeon Woods Richardson is getting the start for the Twins, and he sits with a 1-2 record and an ERA of 4.74. Against the LA Angels, he went 5.1 innings, giving up four hits and one run. 

Another Win for the Guardians 

It was another win for the Guardians on  Wednesday, and the pitchers gave up only two hits on the way to the victory. Luis. L Ortiz went 6.1 innings, giving up three hits and zero runs. He had five strikeouts and two walks. Bo Naylor was the top offensive player, and he ended up hitting a home run and driving in three RBIs. 

The Guardians are averaging 3.79 runs while their pitching is giving up 4.72 runs per game. The offense is ranked 23rd, while the pitching is ranked 23rd. As a team, they are batting .236, which is 20th in baseball. Getting the start for the Guardians will be Ben Lively, who sits with a 1-2 record and an ERA of 3.86. Against the Boston Red Sox, he went five innings, giving up six hits and four runs. 

Minnesota Twins vs Cleveland Guardians Prediction

This game is going to come down to the pitching of Simeon Woods Richardson, and he’s going to have a strong start here. Richardson, in his last start game against the Angels he went 5.1 innings, giving up four hits and one run. Ben Lively, in his last start, gave up six hits and four runs, and the offense for the Twins is suddenly starting to figure out. The Twins’ offense is going to give Woods Richardson some run support, and Minnesota is going to end up coming away with the victory. 

Shane Mickle's Pick: Twins ML

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