Jul 22, 2026; Cleveland, Ohio, USA; Cleveland Guardians left fielder Steven Kwan (38) catches a fly ball in the fifth inning against the Minnesota Twins at Progressive Field. Mandatory Credit: David Richard-Imagn Images
David Richard-Imagn Images

Minnesota Twins vs Cleveland Guardians Prediction 7/23/2026 Today’s MLB Picks

Pick details

MATCHUP Minnesota Twins Cleveland Guardians
Team Records 50-53 54-49
Spread +1.5 -188 -1.5 154
Moneyline +117 -141
Total Over 7.5 (-118) Under 7.5 (-102)
Where Progressive Field, Cleveland, Ohio
When Thursday, July 23, 2026
Time 01:10 PM EDT
TV ESPN Unlmtd

The Minnesota Twins and Cleveland Guardians meet Thursday in MLB action at Progressive Field. Here’s a Minnesota Twins vs Cleveland Guardians Prediction. This article will include a Minnesota Twins vs Cleveland Guardians Pick.

Minnesota Twins Betting Preview


The Minnesota Twins are 50-53 on the year and play the Athletics and Royals next. The Minnesota Twins are batting .248 on the season and have a .321 OBP and a .413 slugging percentage. The Minnesota Twins’ pitching staff has a 4.77 ERA and a 1.40 WHIP. Josh Bell leads the Minnesota Twins with 92 hits and 62 RBI, while Byron Buxton and Brooks Lee have combined for 178 hits and 101 RBI.

Taj Bradley gets the ball for the Minnesota Twins, and he is 9-4 with a 3.85 ERA and 124 strikeouts this season. Bradley is 2-1 with a 1.54 ERA and 31 strikeouts in his career against the Cleveland Guardians.

Cleveland Guardians Betting Preview


The Cleveland Guardians are 54-49 on the year and play the Rays and Reds next. The Cleveland Guardians are batting .234 on the season, have a .313 OBP, and have a .378 slugging percentage. The Cleveland Guardians’ pitching staff has a 3.74 ERA and a 1.27 WHIP. Brayan Rocchio leads the Cleveland Guardians with 95 hits and 48 RBI, while Chase DeLauter and Steven Kwan have combined for 171 hits and 68 RBI.

Gavin Williams gets the ball for the Cleveland Guardians, and he is 10-5 with a 4.00 ERA and 145 strikeouts this season. Williams is 4-3 with a 3.27 ERA and 47 strikeouts in his career against the Minnesota Twins.

Why the Cleveland Guardians will win

  • The Twins have lost nine of their last 10 day games against the Guardians following a road win.
  • The Guardians have won eight of their last nine day games against the Twins at Progressive Field following a home loss.
  • The Guardians have covered the run line in each of their last four games following a loss.
  • The Twins have failed to cover the run line in 12 of their last 13 Thursday day games against AL Central opponents that held a winning record.
  • The Twins have trailed after 3 innings in four of their last five games.

Why the Minnesota Twins will win

  • The underdogs have won four of the last five games between the Twins and Guardians at Progressive Field.
  • The Guardians have lost three of their last four games as home favorites against AL Central opponents.
  • The underdogs have covered the run line in 15 of the last 17 games between the Twins and Guardians at Progressive Field.
  • The Guardians have failed to cover the run line in 15 of their last 17 games as home favorites after playing the previous day.
  • The Twins have led after 5 innings in seven of their last nine games as road underdogs against American League opponents.

Total Runs Facts

  • Five of the Twins’ last six road games against AL Central opponents have gone OVER the total runs line.
  • Four of the Guardians’ last five day games against AL Central opponents have gone UNDER the total runs line.
  • There has been at least one run scored in the first inning in each of the Twins’ last nine games as road underdogs.
  • There has been at least one run scored in the first inning in each of the Guardians’ last five home games against American League opponents.

Cleveland Guardians Player Prop Facts

  • Rhys Hoskins has hit at least one home run in three of his last four appearances against AL Central opponents.
  • Gavin Williams has recorded seven or more strikeouts in three of his last four appearances against AL Central opponents that held a losing record.
  • Brayan Rocchio has recorded at least one hit in each of the Guardians’ last 11 games as home favorites against AL opponents.
  • Jose Ramirez ranks 7th in the league in Steals (24) this season.

Minnesota Twins Player Prop Facts

  • Byron Buxton has hit a home run in three of his last five appearances with the Twins as underdogs against AL Central opponents.
  • Taj Bradley has recorded six or more strikeouts in each of his four previous appearances against the Guardians.
  • Ryan Jeffers has recorded at least one hit in each of his last 10 appearances with the Twins as road underdogs against AL Central opponents.
  • Taj Bradley has recorded a win in three of his last four appearances.
  • Byron Buxton ranks 8th in the league in Home Runs (25) this season.

Matchup/League Facts

  • The Guardians rank 29th in the league for slugging percentage this season (.378).
  • The Guardians rank 29th in the league for slugging percentage this season (.378).
  • The Twins rank 26th in the league for opponent batting average this season (.256).
  • The Twins rank 26th in the league for opponent batting average this season (.256).

Minnesota Twins vs Cleveland Guardians Prediction


Bradley has been solid this season, but his numbers do jump to a 4.50 ERA and a .245 allowed batting average in 56 innings on the road. The Twins have also had issues stringing wins together as of late. The Guardians are the better side, and while Williams is having a rough July, he has a 3.45 ERA and .230 allowed batting average in 60 innings at home. Quick turnaround; I trust the Guardians at home in this spot.

Randy Chambers's Pick: Cleveland Guardians

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