Milwaukee Brewers vs St. Louis Cardinals Prediction 5/6/2026 Today’s MLB Picks

The Milwaukee Brewers and the St. Louis Cardinals meet Wednesday in MLB action from Busch Stadium. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Milwaukee Brewers vs. St. Louis Cardinals prediction.

Starting Pitching Matchup

The Milwaukee Brewers will send out Brandon Sproat for the start here and Sproat is 0-2 with a 6.75 ERA and 25 strikeouts this season. This will be Sproat’s first career start against the Cardinals. Andre Pallante will start for the Cardinals in this one and is 3-2 with a 3.73 ERA and 26 strikeouts this season. In his career, Pallante is 0-2 with a 6.28 ERA and 10 strikeouts.

Milwaukee Brewers Recap

The Milwaukee Brewers come into this game looking to bounce back from a 6-3 loss at the hands of the St. Louis Cardinals last time out to sit at 18-16 this season. After this series, the Brewers will head home for a series against the New York Yankees. 

Brewers Drop Back-To-Back Games

William Contreras has 38 hits with 7 doubles, 3 home runs and 23 RBIs while Brice Turang’s added 35 hits with 8 doubles, a triple, 5 homers and 22 RBIs. Jake Bauers has 28 hits with 6 doubles, 5 home runs and 19 RBIs and Sal Frelick’s added 22 hits with 3 home runs and 9 RBIs this season. Luis Rengifo’s added 19 hits with 8 doubles and 11 RBIs and Garrett Mitchell has 21 hits wtih 6 doubles and 21 RBIs this season. 

St. Louis Cardinals Recap

The St. Louis Cardinals come into this game looking to add on to their win over Milwaukee from Monday’s game to improve to 21-14 this season. After this series, the Cardinals will head on the road for a series against the San Diego Padres.

Cardinals Win 7 Of Last 8

Jordan Walker leads the Cardinals with 40 hits, 6 doubles, 10 home runs and 27 RBIs while Alec Burleson has 36 hits with 9 doubles, 5 home runs and 28 RBIs. JJ Wetherholt has 33 hits with 7 home runs and 18 RBIs while Ivan Herrera has 32 hits with 9 doubles, 4 home runs and 17 RBIs. Nolan Gorman has 26 hits with 5 home runs and 21 RBIs this season. Masyn Winn’s added 31 hits with 6 doubles and 14 RBIs and Nathan Church has 25 hits with 5 home runs and 16 RBIs this season. 

Milwaukee Brewers @ St. Louis Cardinals Betting Trends: May 6, 2026

• Probable Starting Pitcher: Andre Pallante      Record this season: 3-2      ERA: 3.73
• Home Record: 1-2
• Last 5 against Brewers: 0-2

Why the St. Louis Cardinals will win

• The Cardinals have won seven of their last eight games.
• The Brewers have lost seven of their last eight road games against National League opponents that held a winning record.
• The Cardinals have covered the run line in each of their last six games against the Brewers.
• The Brewers have failed to cover the run line in seven of their last eight road games against National League opponents following a loss.
• The Brewers have lost the first inning in four of their last five road games against National League opponents that held a winning record.
• The Cardinals have led after 5 innings in each of their last six games against the Brewers.
• The Cardinals have led after 3 innings in each of their last four games against NL Central opponents.

• Probable Starting Pitcher: Brandon Sproat      Record this season: 0-2      ERA: 6.75
• Road Record: 0-1
• Last 5 against Cardinals: –

Why the Milwaukee Brewers will win

• The Brewers have won each of their last eight day games against NL Central opponents following a loss.
• The Cardinals have lost six of their last seven games as favorites against the Brewers following a win.
• The Brewers have covered the run line in each of their last 16 games as road underdogs against NL Central opponents following a road loss.
• The Cardinals have failed to cover the run line in each of their last 12 games as favorites against National League opponents following a home win.
• The Brewers have led after 5 innings in four of their last five day games against NL Central opponents that held a winning record.
• The Brewers have led after 3 innings in three of their last four games against opponents that held a winning record.

Total Runs Facts

• Five of the Cardinals’ last six day games against National League opponents have gone UNDER the total runs line.
• Six of the Brewers’ last eight games as underdogs against National League opponents have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Brewers’ last four games against NL Central opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in five of the Cardinals’ last six home games against National League opponents.

St. Louis Cardinals Player Prop Facts

• Alec Burleson has recorded at least one hit in each of his 10 previous appearances against the Brewers after not playing the previous day.
• Lars Nootbaar has hit a home run in three of his last eight home appearances after not playing the previous day.
• Jordan Walker ranks 7th amongst qualified players for Slugging Percentage (.585) this season.

Milwaukee Brewers Player Prop Facts

• Sal Frelick has recorded at least one hit in each of his last 12 road appearances against NL Central opponents.
• Gary Sanchez has hit a home run in three of his last four road appearances against NL Central opponents that held a winning record.
• Brice Turang ranks 3rd amongst qualified players for On Base Percentage (.434) this season.

Matchup/League Facts

• The Cardinals rank 30th in the league for strikeouts this season (243).
• The Cardinals rank T27th in the league for triples this season (1).
• The Brewers rank T1st in the league for home runs allowed this season (28).
• The Brewers rank 29th in the league for home runs this season (23).

Milwaukee Brewers vs. St. Louis Cardinals Prediction

I’m on the Cardinals in this one. I just think that St. Louis is the team in better form here and I think that Sproat is the weakest link in this Brewers starting rotation. St. Louis is coming off of a strong series against the Dodgers and carried that momentum into Monday’s opener and I think they pick up another win here. Give me the Cardinals.

Chris Ruffolo's Pick: St. Louis -110