Jun 12, 2025; Milwaukee, Wisconsin, USA;  Milwaukee Brewers pitcher Jacob Misiorowski (33) throws a pitch during the third inning against the St. Louis Cardinals at American Family Field. Mandatory Credit: Jeff Hanisch-Imagn Images

Milwaukee Brewers vs Chicago Cubs Prediction 06/18/2025 Picks

Pick details

Milwaukee (39-35) vs Chicago (45-28)

June 18, 2025 at 08:05 PM EDT

The Line: Betting Odds: Chicago — Over/Under:

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The Milwaukee Brewers and Chicago Cubs meet Wednesday in MLB action at Wrigley Field. Here’s a Milwaukee Brewers vs Chicago Cubs Prediction. This article will include a Milwaukee Brewers vs Chicago Cubs Pick.

Milwaukee Brewers Betting Preview

The Milwaukee Brewers are 39-35 on the year and play the Twins, Pirates, and Rockies next. The Milwaukee Brewers are batting .237 on the season, have a .313 OBP, and a .366 slugging percentage. The Milwaukee Brewers pitching staff has a 3.80 ERA and a 1.30 WHIP. Jackson Chourio leads the Milwaukee Brewers with 81 hits and 42 RBI, while Sal Frelick and Brice Turang have combined for 144 hits and 52 RBI. 

Jacob Misiorowski gets the ball for the Milwaukee Brewers, and he is 1-0 with a 0.00 ERA and 5 strikeouts this season. This will be Misiorowski’s first career game against the Chicago Cubs.

Chicago Cubs Betting Preview

The Chicago Cubs are 45-28 on the year and play the Mariners, Cardinals, and Astros next. The Chicago Cubs are batting .254 on the season, have a .324 OBP, and a .436 slugging percentage. The Chicago Cubs pitching staff has a 3.56 ERA and a 1.22 WHIP. Nico Hoerner leads the Chicago Cubs with 77 hits and 29 RBI while Pete Crow-Armstrong and Kyle Tucker have combined for 154 hits and 101 RBI.

Jameson Taillon gets the ball for the Chicago Cubs, and he is 7-3 with a 3.48 ERA and 65 strikeouts this season. Taillon is 5-9 with a 3.13 ERA and 93 strikeouts in his career against the Milwaukee Brewers.

Why the Chicago Cubs will win

The Cubs have won seven of their last eight night games against NL Central opponents.
The Brewers have lost five of their last six games at Wrigley Field against teams that held a winning record.
The Brewers have failed to cover the run line in seven of their last eight games against National League opponents that held a winning record.
The Cubs have covered the run line in four of their last five night games against NL Central opponents.
The Brewers have trailed after 5 innings in five of their last six games at Wrigley Field.

Why the Milwaukee Brewers will win

The Brewers have won 11 of their last 13 games as road underdogs against NL Central opponents following a road loss.
The Cubs have lost 11 of their last 16 games as home favorites against NL Central opponents following a win.
The Brewers have covered the run line in each of their last 12 games as road underdogs against NL Central opponents following a loss.
The Cubs have failed to cover the run line each of their last 11 Wednesday games against National League opponents that held a winning record.
The Cubs have trailed after 3 innings in each of their last seven Wednesday games against National League opponents that held a winning record.

Chicago Cubs Player Prop Facts

Seiya Suzuki has hit a home run in each of the Cubs’ last two games against the Brewers at Wrigley Field.
Nico Hoerner has scored a run in each of the Cubs’ last five home games against NL Central opponents that held a winning record.
Seiya Suzuki has recorded at least one RBI in each of the Cubs’ last three night games.
Jameson Taillon has recorded five or more strikeouts in 11 of his last 12 Wednesday appearances with his team as a favorite.
Nico Hoerner has recorded at least one hit in each of the Cubs’ last eight night games against NL Central opponents that held a winning record.
Jameson Taillon has recorded a win in each of his last five appearances with the Cubs as favorites.
Jameson Taillon ranks T6th in the league for Wins (7) this season.

Milwaukee Brewers Player Prop Facts

William Contreras has recorded a Double in four of the Brewers’ last five road games against the Cubs.
William Contreras has recorded at least one hit in each of his last 12 road appearances against the Cubs.
Jackson Chourio has hit a home run in two of the Brewers’ last three games as underdogs against NL Central opponents.
Blake Perkins has recorded at least one RBI in seven of his last eight Wednesday night appearances against teams that held a winning record.
Blake Perkins has scored at least one run in eight of his last 10 appearances with the Brewers as road underdogs against NL Central opponents.

Milwaukee Brewers vs Chicago Cubs Prediction

The Cubs are playing the better baseball right now, and Taillon has been strong this season with his 3.56 ERA and 0.98 WHIP. However, the Brewers are worth a look with Misiorowski on the mound, a top-100 prospect who flashed positives in his MLB holding, holding the Cardinals to zero hits and zero runs in five innings. It’s just one start, but it checks out with how hyped up Misiorowski is by scouts. I’ll take a stab with the Brewers.  

Randy Chambers's Pick: Milwaukee Brewers

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