Jun 20, 2025; Chicago, Illinois, USA;  Seattle Mariners catcher Cal Raleigh (29) and pitcher Casey Legumina (64) celebrate after the game asgsinst the Chicago Cubs at Wrigley Field. Mandatory Credit: Matt Marton-Imagn Images

Mariners vs Cubs Prediction 06/21/2025 Picks

Pick details

Seattle (38-36) vs Chicago (45-30)

June 21, 2025 at 02:20 PM EDT

The Line: Betting Odds: Chicago -175 — Over/Under: 12.5

(Get latest betting odds)

In this article we will formulate a Mariners vs Cubs prediction for this MLB game on Saturday, June 21st at Wrigley Field in Chicago, Illinois. Let’s take a look at the prediction for this MLB matchup. 

Seattle Mariners Betting Preview
The Seattle Mariners are 38-36 this year after they won game one in this series by a score of 9-4 on Friday afternoon. Seattle trailed 4-2 in the fifth inning, but they scored the last seven runs in the game for the win. The Mariners recorded 13 hits in the game and they were led by Raleigh, who went 3-4 with two home runs and three RBIs in the win. Seattle started Kirby, who allowed seven hits and four earned runs over 5.0 innings, while Bazardo picked up the win in relief. 

Prior to this series, the Mariners lost two out of three against the Red Sox, but swept the Guardians before that. Seattle has won five of their last seven games and they are currently second in the AL West standings. The Seattle pitching staff has a 3.87 ERA with a 1.28 WHIP and a .249 opponent batting average, while the offense has scored 326 runs with a .243 batting average and a .323 on base percentage this season. Cal Raleigh has led Seattle with 29 home runs and 63 RBIs, while Jorge Polanco has added 11 home runs and 36 RBIs this year. The projected starting pitcher for Seattle is Emerson Hancock, who is 3-2 with a 4.48 ERA and a 1.38 WHIP over 62.1 innings pitched this year. 

Chicago Cubs Betting Preview
The Chicago Cubs are 45-30 this season after they lost game one in this series on Friday afternoon. Chicago led 3-1 in the first inning and 4-2 in the fifth, but they went scoreless over the final four innings for the loss. The Cubs recorded nine hits in the game and they were led by Busch, who went 3-4 with two RBIs in the loss. Chicago started Boyd, who allowed two hits and two earned runs over 5.0 innings, while Thielbar picked up the loss in relief. 

Prior to this series, the Cubs split two games with the Brewers and won three out of four against the Pirates. Chicago has won three of their last five games and they are currently first in the NL Central standings. The Chicago pitching staff has a 3.69 ERA with a 1.24 WHIP and a .245 opponent batting average, while their offense has scored 401 runs with a .254 batting average and a .325 on base percentage this season. Pete Crow-Armstrong has led Chicago with 20 home runs and 60 RBIs, while Seiya Suzuki has added 18 home runs and 61 RBIs this year. The projected starting pitcher for Chicago is Cade Horton, who is 3-1 with a 3.47 ERA and a 1.21 WHIP over 36.1 innings pitched this season. 

Why the Cubs will beat the Mariners
The Mariners have lost each of their last four road games following a win.
The Cubs have won 11 of their last 13 games following a loss.
The Mariners have failed to cover the run line in 11 of their last 12 road games after playing the previous day.
The Cubs have covered the run line in eight of their last 10 games as favorites against American League opponents.
The Mariners have trailed after 5 innings in four of their last five games at Wrigley Field.
The Mariners have trailed after 3 innings in four of their last five road games against National League opponents.

Total Runs Facts
Each of the Cubs’ last seven games as favorites against AL West opponents have gone OVER the total runs line.
Each of the Mariners’ last four day games after playing the previous day have gone UNDER the total runs line.
The ‘Inning 1 OVER 0.5 runs’ market has hit in 13 of the Mariners’ last 14 day games against National League opponents.
The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Cubs’ last six games as favorites against American League opponents.

Chicago Cubs Player Prop Facts
Ian Happ has hit a home run in each of the Cubs’ last two games as home favorites.
Ian Happ has scored a run in each of the Cubs’ last seven games against AL West opponents.
Seiya Suzuki has recorded at least one Double in three of the Cubs’ last four games against AL opponents at Wrigley Field.
Justin Turner has recorded at least one hit in each of his last seven home appearances against the Mariners.
Ian Happ has recorded at least one RBI in each of the Cubs’ last four day games.

Seattle Mariners Player Prop Facts
Cal Raleigh has hit at least one home run in five of the Mariners’ last six road games against NL opponents that held a winning record.
Randy Arozarena has recorded at least one hit in each of the Mariners’ last nine road games against opponents that held a winning record.
Victor Robles has scored at least one run in six of his last seven appearances in day games.
Randy Arozarena has recorded at least one Double in each of his last three appearances at Wrigley Field against opponents that held a winning record.
Cal Raleigh has recorded at least one RBI in each of the Mariners’ last six road games against NL opponents that held a winning record.

Mariners vs Cubs Prediction 
Seattle was able to score nine runs in their win on Friday to start this series, but they have struggled to string wins together, as they have alternated wins and losses in their last five games. The Mariners are 18-17 on the road this year, while the Cubs are 24-14 at home. Chicago has allowed 17 runs in their last two games and they are starting Horton, who has allowed two earned runs or fewer in four of his last five starts. Seattle is going with Hancock, who has allowed two earned runs or fewer in four straight outings. I have been backing Hancock in recent starts, but I don’t love his matchup here on the road. Take the Cubs -1.5 in this game. 

David Racey's Pick: Cubs -1.5

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