Los Angeles Dodgers vs Arizona Diamondbacks Prediction 9/25/2025 Today’s MLB Picks

The Los Angeles Dodgers and the Arizona Diamondbacks meet Thursday in MLB action from Chase Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Los Angeles Dodgers vs. Arizona Diamondbacks prediction.

Starting Pitching Matchup

The Los Angeles Dodgers will send out Yoshinobu Yamamoto here and Yamamoto is 11-8 with a 2.58 ERA and 194 strikeouts this season. In his last five starts against the Diamondbacks, Yamamoto is 2-1 with a 2.30 ERA and 36 strikeouts. Zac Gallen will get the start for the Diamondbacks here and is 13-14 with a 4.70 ERA and 172 strikeouts this season. In his last five starts against the Dodgers, Gallen is 1-2 with a 6.23 ERA and 27 strikeouts.

Los Angeles Dodgers Recap

The Los Angeles Dodgers come into this game looking to build on their 5-4 extra innings win over Arizona from Wednesday’s matchup to improve to 89-69 this season. After this series, the Dodgers will head on the road for an interleague series against the Seattle Mariners.

Dodgers Looking To Build Momentum

Shohei Ohtani has 167 hits including 24 doubles, 53 home runs, 99 RBIs and 8 triples. Michael Conforto has 82 hits with 20 doubles while Teoscar Hernandez has 120 hits with 24 home runs, 28 doubles and 85 RBIs as well this season. Ohtani has a team-high 19 stolen bases while Max Muncy has 10 doubles but also has 73 strikeouts so far this season. Mookie Betts has also chipped in 20 home runs and 79 RBIs as well on the year. Freddie Freeman has also logged 158 hits with a team-high 39 doubles, 21 home runs and 85 RBIs. Andy Pages also has 155 hits with 27 doubles, 25 home runs and 82 RBIs as well this season.

Arizona Diamondbacks Recap

The Arizona Diamondbacks come into this game looking to bounce back from their loss at the hands of the Dodgers last time out, sitting at 80-78 this season. After this series, the Diamondbacks will head on the road for a series against the San Diego Padres.

Diamondbacks Have Three-Game Win Streak Snapped

Corbin Carroll has 143 hits with 31 home runs, 83 RBIs, 17 triples and 31 doubles this season. Carroll also has a team-high 30 stolen bases and Geraldo Perdomo has 26 stolen bases as well as 19 home runs and 97 RBIs with a team-high 166 hits this season. Ketel Marte’s added 26 home runs and 70 RBIs as well on the year and Lourdes Gurriel has 124 hits with 24 doubles, 19 home runs and 80 RBIs.

Los Angeles Dodgers @ Arizona Diamondbacks Betting Trends: September 25, 2025

• Probable Starting Pitcher: Zac Gallen      Record this season: 13-14      ERA: 4.70
• Home Record: 6-7
• Last 5 against Dodgers: 2-1

Why the Arizona Diamondbacks will win

• The Dodgers have lost seven of their last eight games as road favorites following a win.
• The Diamondbacks have won each of their last seven day games against NL West opponents following a home loss.
• The Diamondbacks have covered the run line in each of their last eight games as home underdogs.
• The Dodgers have failed to cover the run line in each of their last six games as favorites after going to extra innings.
• The Diamondbacks have led after 3 innings in each of their last four day games against opponents that held a winning record.
• The Diamondbacks have won the first inning in 11 of their last 14 home games against National League opponents that held a winning record.
• The Diamondbacks have led after 5 innings in seven of their last eight day games at Chase Field against National League opponents.

• Probable Starting Pitcher: Yoshinobu Yamamoto      Record this season: 11-8      ERA: 2.58
• Road Record: 8-4
• Last 5 against Diamondbacks: 2-1

Why the Los Angeles Dodgers will win

• The Dodgers have won each of their last nine day games against NL West opponents that held a winning record.
• The Diamondbacks have lost six of their last seven day games against National League opponents following a loss.
• The Dodgers have covered the run line in each of their last six Thursday day games against NL West opponents.
• The Diamondbacks have failed to cover the run line in eight of their last 10 games against National League opponents after going to extra innings.
• The Dodgers have won the first inning in six of their last eight day games.
• The Dodgers have led after 5 innings in each of their last seven games against opponents that held a winning record.
• The Dodgers have led after 3 innings in each of their last three day games against the Diamondbacks.

Total Runs Facts

• Seven of the Dodgers’ last eight road games after going to extra innings have gone OVER the total runs line.
• Nine of the Diamondbacks’ last 11 home games following an extra innings loss have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in 17 of the Diamondbacks’ last 19 home games against National League opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in six of the Dodgers’ last eight day games.

Arizona Diamondbacks Player Prop Facts

• Geraldo Perdomo ranks 5th amongst qualified players for On Base Percentage (.391) this season.

Los Angeles Dodgers Player Prop Facts

• Shohei Ohtani ranks 2nd amongst qualified players for Slugging Percentage (.617) this season.

Matchup/League Facts

• The Diamondbacks rank 1st in the league for triples this season (37).
• The Diamondbacks rank 3rd in the league for RBIs this season (757).
• The Dodgers rank 2nd in the league for runs scored this season (798).
• The Dodgers rank 2nd in the league for RBIs this season (765).

Los Angeles Dodgers vs. Arizona Diamondbacks Prediction

I’m going to side with Arizona here. I think that both of these starters have a solid outing, and while Arizona’s bullpen has been less trustworthy for much of the season, I still think that the Diamondbacks sense of urgency kicks in here as the Dodgers are almost locked into the 3-seed in the National League. I think Arizona gets another key win in the Wild Card race and gets the job done here. Give me Arizona.