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Astros vs Angels Prediction 06/21/2025 Picks
Pick details
Houston (44-32) vs Los Angeles (36-39)
June 21, 2025 at 09:38 PM EDT
The Line: Betting Odds: Los Angeles -105 / Houston -115 — Over/Under: +8.5
The Houston Astros are visiting the Los Angeles Angels on Saturday, June 21st at the Angel Stadium in the second game of this series, with the Astros having the 1-0 lead. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Houston Astros vs Los Angeles Angels Prediction. We will examine:
The Los Angeles Angels recent form and player performance
The Houston Astros recent form and player performance
Recent betting trends and streaks involving the Los Angeles Angels
Recent betting trends and streaks involving the Houston Astros
Recent betting trends in games played between the Houston Astros vs Los Angeles Angels
A summary that ties it all together and produces a favorable betting outcome for the Houston Astros vs Los Angeles Angels game
Los Angeles Angels Preview
The Los Angeles Angels have a 36-39 record this season and are sitting on the 4th place of the AL West. The Angels have a 15-17 home record and 38-36 in over/under They are coming off a 2-3 home defeat by the Astros, and have back-to-back losses. Under is 5-0 in their last 5 games and are playing the Red Sox and the Nationals next.
The Angels have a .224 batting average this season, .287 OBP and .397 Slugging percentage. LA’spitching staff has a 4.63 ERA and 1.47 WHIP. Nolan Schanuel leads the Angels with 72 hits and he is the team’s best hitter with a .273 batting average. Taylor Ward leads the team with 50 RBI and a team-high 19 home runs.
Jose Soriano (R) will take the mound for the Angels, and he has a 4-5 record, 3.54 ERA and 1.46 WHIP. He has been weaker at home with a 4.88 ERA across six home starts, but he has been in excellent form lately, having given up just one run in 14 innings pitched across his last two starts. José Soriano with an ERA of 2.45 and 4 strikeouts in 4 appearances versus the Astros in his career.
Houston Astros Preview
The Houston Astros have a 44-32 record this season and are sitting on the first place of the AL West. The Astros have a 17-19 road record and 31-42 in over/under. They are coming off a 3-2 road victory over the Angels, and are 8-2 in their last 10 games. Over is 3-1 in their last 4 games, and they are playing the Cubs and the Phillies next.
The Astros have a .258 batting average this season, .323 OBP and .402 slugging percentage. Houston’s pitching staff has a 3.40 ERA and 1.15 WHIP. Jeremy Pena leads the Astros with 97 hits and he is the team’s best hitter, with a .328 batting average. Isaac Paredes leads the team in RBI with 45, adding a team-high 16 home runs.
Brandon Walter (L) is the projected starter for the Astros, and he has a 0-0 record, 1.53 ERA and 0.91 WHIP. In his three starts this season, he has only 3 earned runs across 17.2 innings pitched, and this will be his first career start versus the Angels.
Why the Los Angeles Angels will win
The Astros have lost each of their last six games following an extra innings win.
The Angels have won five of their last six games as underdogs following an extra innings loss.
The Angels have covered the run line each of their last nine night games against teams that held a winning record.
The Astros have failed to cover the run line in eight of their last nine games after going to extra innings.
The Angels have led after 5 innings in seven of their last eight Saturday night games as underdogs.
Why the Houston Astros will win
The Astros have won seven of their last eight games at Angel Stadium of Anaheim.
The Angels have lost seven of their last eight night games against the Astros following a loss.
The Angels have failed to cover the run line in four of their last five games against American League opponents after going to extra innings.
The Astros have covered the run line in five of their last six night games against the Angels following a win.
The Angels have lost the first inning in four of their last five home games against opponents that held a winning record.
The Astros have led after 5 innings in each of their last four games against the Angels at Angel Stadium of Anaheim.
The Astros have led after 3 innings in six of their last seven games against the Angels.
Total Runs Facts
Each of the Angels’ last six night games against American League opponents have gone UNDER the total runs line.
Ten of the Astros’ last 12 road games after going to extra innings have gone UNDER the total runs line.
The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Astros’ last six Saturday night games against American League opponents.
The ‘Inning 1 OVER 0.5 runs’ market has hit in nine of the Angels’ last 11 games as home underdogs against American League opponents.
Matchup/League Facts
The Angels rank 30th in the league for on-base percentage this season (.287).
The Angels rank 29th in the league for doubles this season (96).
The Astros rank 1st in the league for strikeouts this season (746).
The Astros rank 1st in the league for opponent batting average this season (.218).
Houston Astros vs Los Angeles Angels Prediction
The Astros are 9-2 in their last 11 overall meetings against the Angels, and have won their last four visits in Los Angeles. Over is 5-2 in their last 7 meetings.
In this Houston Astros vs Los Angeles Angels Prediction, the Astrosare coming as -115 road favorites. Houston is rightfully favored, as they have a better overall record, but they have been below average on the road, and the Angels have been weak at home as well. The Astros have the 5th-best bullpen this season, while the Angels have the 4th-worst. The Angels are the weakest team against lefties this season, and Soriano has been excellent lately. With Brandon Walter also looking good in his three starts so far, I don’t expect a lot of scoring with those two pitchers on the mound, so take the under in the first 5 innings.