Houston Astros vs Pittsburgh Pirates Prediction 6/4/25 MLB Picks

The Houston Astros and Pittsburgh Pirates meet Wednesday in MLB action at PNC Park. Here’s a Houston Astros vs Pittsburgh Pirates Prediction. This article will include a Houston Astros vs Pittsburgh Pirates Pick.

Houston Astros Betting Preview

The Houston Astros are 33-27 on the year and play the Guardians, White Sox, and Twins next. The Houston Astros are batting .252 on the season, have a .319 OBP, and a .391 slugging percentage. The Houston Astros’ pitching staff has a 3.59 ERA and a 1.16 WHIP. Jeremy Pena leads the Houston Astros with 70 hits and 30 RBI, while Jose Altuve and Isaac Paredes have combined for 116 hits and 56 RBI. 

Ryan Gusto gets the ball for the Houston Astros, and he is 3-2 with a 4.62 ERA and 42 strikeouts this season. This will be Gusto’s first career game against the Pittsburgh Pirates.

Pittsburgh Pirates Betting Preview

The Pittsburgh Pirates are 22-39 on the year and play the Phillies, Marlins, and Cubs next. The Pittsburgh Pirates are batting .226 on the season, have a .304 OBP, and a .337 slugging percentage. The Pittsburgh Pirates’ pitching staff has a 3.46 ERA and a 1.00 WHIP. Bryan Reynolds leads the Pittsburgh Pirates with 54 hits and 34 RBI, while Isiah Kiner-Falefa and Ke’Bryan Hayes have combined for 99 hits and 31 RBI.

Mike Burrows gets the ball for the Pittsburgh Pirates, and he is 0-1 with an 8.64 ERA and 5 strikeouts this season. This will be Burrows’ first career game against the Houston Astros.

Why the Pittsburgh Pirates will win

• The Astros have lost each of their last five games as road favorites following a win.
• The Pirates have won five of their last six games as underdogs against the Astros following a loss.
• The Pirates have covered the run line in each of their last eight games as underdogs against AL West opponents following a home loss.
• The Astros have failed to cover the run line in seven of their last eight road games against National League opponents that held a losing record.
• The Pirates have led after 5 innings in each of their last five Wednesday night games against AL West opponents that held a winning record.

Why the Houston Astros will win

• The Pirates have lost each of their last eight Wednesday night home games against American League opponents.
• The Astros have won four of their last five games against National League opponents.
• The Pirates have failed to cover the run line in 10 of their last 11 home games against American League opponents.
• The road team has covered the run line in each of the Astros’ last five games.
• The Astros have led after 5 innings in three of their last four games as favorites against National League opponents.

Pittsburgh Pirates Player Prop Facts

• Andrew McCutchen has hit a home run in each of the Pirates’ last two games as underdogs.
• Bryan Reynolds has recorded at least one RBI in four of the Pirates’ last five games as underdogs against AL opponents.
• Isiah Kiner-Falefa has recorded at least one Single in each of his last six appearances against opponents that held a winning record.
• Oneil Cruz has scored at least one run in five of his last six home appearances after playing the previous day.
• Jared Triolo has recorded a Double in three of his last four appearances in night games against AL West teams that held a winning record.
• Tommy Pham has recorded at least one hit in each of his last eight appearances with his team as an underdog against AL West opponents.

Houston Astros Player Prop Facts

• Jake Meyers has recorded a Double in each of the Astros’ last three night games against opponents that held a losing record.
• Isaac Paredes has hit at least one home run in each of the Astros’ last three road games against opponents that held a losing record.
• Isaac Paredes has recorded an RBI in four of the Astros’ last five games as favorites against NL Central opponents.
• Jeremy Pena has scored at least one run in each of the Astros’ last four games against opponents that held a losing record.
• Jeremy Pena has recorded at least one Single in each of the Astros’ last six games against NL Central opponents that held a losing record.
• Mauricio Dubon has recorded at least one hit in each of his last eight appearances against opponents that held a losing record.

Houston Astros vs Pittsburgh Pirates Prediction

I’m not excited to get behind Gusto, a pitcher who has allowed 17 hits and 11 earned runs in his last 12 innings. The Astros have lost each of Gusto’s last five games. However, I have no choice, as the Pirates are the Pirates, and Burrows hasn’t been any better, as he’s allowed nine hits and eight earned runs in 8.1 innings. In 11.2 MLB innings for his career, Burrows has allowed 11 hits and nine earned runs. The pitching matchup is horrible. The Astros are still the better team by a country mile. So, give me the Astros and the reasonable price.

Randy Chambers's Pick: Houston Astros -142