Detroit Tigers vs Chicago White Sox Prediction 6/5/25 MLB Picks

In this article, we will formulate a Tigers vs White Sox prediction for this MLB game on Thursday, June 5, at Rate Field in Chicago, Illinois. Let’s take a look at the prediction for this MLB matchup.

Detroit Tigers Betting Preview

The Detroit Tigers (41-22, 20-14 Away) bounced back from a series loss to the Cleveland Guardians with a sweep of the Giants and a win against the Royals. Following a 5-4 victory over the White Sox last night, the Tigers lead this series 2-1. Riley Greene led the offense with two RBI, while Sawyer Gipson-Long pitched for 3.2 innings in a no-decision, allowing three runs on five hits with three strikeouts and one walk. Will West was credited with the win. 

This season, the Tigers average 5.00 runs per game (5th in the MLB) on a .251/.323/.410 triple-slash. When it comes to pitching, the Tigers’ staff has a 3.21 ERA (5th) and 1.16 WHIP (4th). Spencer Torkelson leads the Tigers with a .231 batting average, 14 home runs, and 42 RBI this season.

Casey Mize will take the mound for the Tigers on Thursday. The 28-year-old right-hander has a 6-1 record in nine starts this year with a 2.82 ERA and 1.14 WHIP in 51.0 innings.

Chicago White Sox Betting Preview

The Chicago White Sox (19-43, 13-17 Home) lost a series to the Mets and were swept by the Orioles on the road, and now are looking at the face of another series defeat following two losses in the opening three games against the Tigers. In a 5-4 defeat on Wednesday, Jared Shuster got a start and pitched for 1.0 inning in a no-decision, allowing four runs on five hits with one strikeout and one walk. Brandon Eisert took the loss. 

This year, the White Sox average 3.45 runs per game (25th in the MLB) on a .221/.294/.342 triple-slash. When it comes to pitching, the White Sox’s staff has a 4.21 ERA (23rd) and 1.37 WHIP (23rd). Miguel Vargas leads the White Sox with a .239 batting average, eight home runs, and 26 RBI this season.

The projected starting pitcher for the White Sox is Sean Burke, who is 3-6 in ten starts this season, with a 4.20 ERA and 1.42 WHIP in 60.0 innings.

Total Runs Facts

• Seven of the Tigers’ last eight day games against AL Central opponents have gone UNDER the total runs line.
• Each of the White Sox’s last five home games have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in nine of the Tigers’ last 10 day games.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in five of the last six games between the Tigers and White Sox.

Matchup/League Facts

• The White Sox rank 28th in the league for hits this season (447).
• The White Sox rank 28th in the league for home runs this season (48).
• The Tigers rank 4th in the league for RBIs this season (301).
• The Tigers rank 27th in the league for strikeouts against this season (564).

Tigers vs White Sox Prediction

The Tigers won seven of the previous ten H2H encounters, including five of the last six. The Tigers already swept the White Sox in a series in Detroit earlier this year. Although we had a lot of Over outcomes in recent H2Hs, I am going with Under here because of Sean Burke, who has been excellent in May. Burke allowed more than two runs only once in his previous six starts. Casey Mize, on the other hand, has been great the entire season and allowed more than three runs just two times. Go with Under. 

Oliver Zivic's Pick: Under 8.5