Cubs vs Astros Prediction 06/27/2025 Picks

In this article we will formulate a Cubs vs Astros prediction for this MLB game on Friday, June 27th at Daikin Park in Houston, Texas. Let’s take a look at the prediction for this MLB matchup. 

Chicago Cubs Betting Preview
The Chicago Cubs are 48-33 this year after they split four games with the Cardinals by scores of 2-8, 7-8, 8-0, and 3-0. In their game four win, Chicago scored one run in the second inning, one in the fourth, and one in the eighth in the shutout win. The Cubs recorded nine hits in the game and they were led by Happ and Busch, who both had one RBI in the win. Chicago started Imanaga, who allowed one hit and zero earned runs over 5.0 innings for the win, while four relievers combined to finish the shutout. 

Prior to this series, the Cubs lost two out of three against the Mariners and split two games with the Brewers. Chicago has split their last six games and they are currently first in the NL Central standings. The Chicago pitching staff has a 3.85 ERA with a 1.25 WHIP and a .248 opponent batting average, while their offense has scored 437 runs with a .256 batting average and a .325 on base percentage this season. Pete Crow-Armstrong has led Chicago with 21 home runs and 61 RBIs, while Seiya Suzuki has added 21 home runs and 67 RBIs this year. The projected starting pitcher for Chicago is Cade Horton, who is 3-1 with a 3.73 ERA and a 1.29 WHIP over 41.0 innings pitched this year. 

Houston Astros Betting Preview
The Houston Astros are 48-33 this season after they swept Philadelphia by scores of 1-0, 2-0, and 2-1. In their game three win, Houston allowed the tying run in the eighth inning, but they scored in the bottom half of the inning for the win. The Astros recorded seven hits in the game and they were led by Smith and Diaz, who both had one RBI in the win. Houston started Brown, who allowed three hits and zero earned runs over 7.0 innings, while Abreu picked up the win in relief. 

Prior to that series, the Astros won two out of three against the Angels and split four games with the Athletics. Houston has won four games in a row and they are currently first in the AL West standings. The Houston pitching staff has a 3.40 ERA with a 1.14 WHIP and a .218 opponent batting average, while their offense has scored 338 runs with a .255 batting average and a .321 on base percentage this season. Isaac Paredes has led Houston with 16 home runs and 46 RBIs, while Jeremy Pena has added 11 home runs and 40 RBIs this year. The projected starting pitcher for Houston is Brandon Walter, who is 0-1 with a 3.80 ERA and a 1.10 WHIP over 23.2 innings pitched this season. 

Why the Cubs will beat the Astros
The favorites have won each of the Cubs’ last 10 games at Daikin Park.
The Astros have lost four of their last five games against NL Central opponents following a home win.
The Cubs have covered the run line in each of their last seven road games against AL West opponents following a road win.
The Astros have failed to cover the run line each of their last four night games against NL Central opponents that held a winning record.
The Astros have trailed after 5 innings in six of their last eight games as home underdogs against NL Central opponents.

Total Runs Facts
Each of the Cubs’ last eight games as favorites against AL West opponents have gone OVER the total runs line.
Seven of the Astros’ last eight home games against National League opponents have gone UNDER the total runs line.
The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the last eight night games between the Cubs and Astros.
The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Cubs’ last seven games as favorites against American League opponents.

Houston Astros Player Prop Facts
Yainer Diaz has hit a home run in five of the Astros’ last nine home games against NL Central opponents.
Yainer Diaz has recorded at least one hit in each of the Astros’ last nine home games against NL Central opponents.
Jeremy Pena has recorded a Double in four of the Astros’ last five games against NL opponents that held a winning record.
Jeremy Pena ranks 5th amongst qualified players for Batting Average (.324) this season.

Chicago Cubs Player Prop Facts
Seiya Suzuki has hit at least one home run in each of the Cubs’ last two road games against the Astros.
Justin Turner has recorded at least one hit in each of his last nine road appearances against AL opponents.
Dansby Swanson has recorded a Double in three of the Cubs’ last four games as road favorites against AL opponents.
Kyle Tucker ranks 5th amongst qualified players for On Base Percentage (.395) this season.

Matchup/League Facts
The Astros rank 1st in the league for hits allowed this season (577).
The Astros rank 2nd in the league for runs allowed this season (288).
The Cubs rank 2nd in the league for RBIs this season (428).
The Cubs rank 3rd in the league for home runs this season (119).

Cubs vs Astros Prediction 
Houston comes into this series looking to get their fifth win in a row and they have allowed a total of one run in their last three games. The Astros are 30-13 at home this year, while the Cubs are 23-18 on the road. Chicago has allowed zero runs in their last two games and they are starting Horton, who has allowed two earned runs or fewer in three of his last five starts. The Astros are going with Walter, who has allowed two earned runs or fewer in three of his four outings, but did allow seven earned runs last time out. This is a very interesting pitching matchup, but I trust the Chicago offense in this spot. Take the Cubs here.