Cleveland Guardians vs St. Louis Cardinals Prediction 4/14/2026 Today’s MLB Picks

The Cleveland Guardians and the St. Louis Cardinals meet Tuesday in MLB action from Busch Stadium. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Cleveland Guardians vs. St. Louis Cardinals prediction.

Starting Pitching Matchup

The Cleveland Guardians will send Joey Cantillo for the start here and Cantillo is 1-0 with a 2.45 ERA and 20 strikeouts this season. This will be Cantillo’s first career start against the Cardinals. Michael McGreevy will start for St. Louis here and is 1-1 with a 2.16 ERA and 10 strikeouts this season.

Cleveland Guardians Recap

The Cleveland Guardians come into this game looking to add on to their 9-3 win over St. Louis from Monday’s series opener to sit at 10-7 this season. After this series, the Guardians will head home for a series against the Baltimore Orioles.

Guardians Alternate Wins & Losses In 5 Straight

Entering Monday, Chase DeLauter has 15 hits with 4 doubles, a team-high 5 home runs and 12 RBIs while Steven Kwan has a 14 hits with 2 doubles, a home run and 4 RBIs and Jose Ramirez has 11 hits with 3 doubles, 2 home runs and 7 RBIs this season. Brayan Rocchio has also added 8 hits with a double, a home run and 6 RBIs this season while Angel Martinez has 13 hits with 3 doubles, a homer and 6 RBIs and Rhys Hoskins has added 9 hits with 5 doubles, a home run and 5 RBIs.

St. Louis Cardinals Recap

The St. Louis Cardinals come into this game looking to bounce back from their loss in Monday’s series opener to drop to 8-8 this season. After this series, the Cardinals will head on the road for a series against the Houston Astros.

Cardinals Lose Three Straight Games

Going into Monday’s opener, Jordan Walker leads the Cardinals with 18 hits, 2 doubles, 7 home runs and 14 RBIs while Alec Burleson has 14 hits with a pair of doubles, a pair of home runs and 11 RBIs. JJ Wetherholt has 12 hits with a home run and 5 RBIs while Ivan Herrera has 10 hits with 3 doubles and 6 RBIs. Nolan Gorman has 9 hits with 2 home runs and 9 RBIs this season.

Cleveland Guardians @ St. Louis Cardinals Betting Trends: April 14, 2026

• Probable Starting Pitcher: Michael McGreevy      Record this season: 1-1      ERA: 2.16
• Home Record: 0-0
• Last 5 against Guardians: –

Why the St. Louis Cardinals will win

• The Guardians have lost each of their last five games as road favorites against NL Central opponents following a win.
• The Cardinals have won six of their last eight games as underdogs against AL Central opponents following a loss.
• The Guardians have failed to cover the run line in each of their last six road games following a win.
• The Cardinals have covered the run line in each of their last six Tuesday games as home underdogs.
• The Cardinals have led after 5 innings in three of their last four night games against AL Central opponents.
• The Cardinals have led after 3 innings in three of their last four games against the Guardians.

• Probable Starting Pitcher: Joey Cantillo      Record this season: 1-0      ERA: 2.45
• Road Record: 0-0
• Last 5 against Cardinals: –

Why the Cleveland Guardians will win

• The Cardinals have lost each of their last eight home games against American League opponents that held a winning record.
• The road team has won each of the last four games between the Guardians and Cardinals.
• The Cardinals have failed to cover the run line each of their last six games against American League opponents that held a winning record.
• The Guardians have covered the run line in each of their last six games against NL Central opponents.
• The Guardians have won the first inning in each of their last five Tuesday night games as favorites.
• The Guardians have led after 3 innings in each of their last five Tuesday night games as favorites.
• The Cardinals have trailed after 5 innings in each of their last six home games against AL Central opponents.

Total Runs Facts

• Seven of the Cardinals’ last eight games as underdogs against the Guardians have gone OVER the total runs line.
• Four of the Guardians’ last five games have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Cardinals’ last six games as home underdogs against AL Central opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in eight of the Guardians’ last nine road games against NL Central opponents.

St. Louis Cardinals Player Prop Facts

• Alec Burleson has hit a home run in four of his last 12 appearances against AL Central opponents.
• Lars Nootbaar has recorded at least one hit in each of his last seven appearances in night games against teams that held a winning record.
• Jordan Walker ranks 1st in the league in Home Runs (8) this season.

Cleveland Guardians Player Prop Facts

• Brayan Rocchio has hit a home run in four of the Guardians’ last six games as favorites.
• Steven Kwan has recorded two hits in each of the Guardians’ last four games as favorites against NL opponents.
• Jose Ramirez ranks T2nd in the league in Steals (7) this season.

Matchup/League Facts

• The Cardinals rank 30th in the league for strikeouts this season (97).
• The Cardinals rank 29th in the league for opponent batting average this season (.268).
• The Guardians rank 2nd in the league for strikeouts this season (166).
• The Guardians rank T4th in the league for doubles this season (32).

Cleveland Guardians vs. St. Louis Cardinals Prediction

I’m on the Guardians here. I just think that Cantillo is the better starting option in this game and if anything I think the prime time for St. Louis to get the win was on Monday but here, I think the Guardians keep their foot on the gas against McGreevy, who for me is one of the weakest starters in the Cardinals’ rotation. Give me Cleveland.

Chris Ruffolo's Pick: Cleveland -115